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GeneWiki Entry History

Most Recent Version:
Gene Symbol: Chrna3
Species: mouse
Web URL: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18227835
Entry: Strong candidate for nicotine dependence in human association studies. In a GWAS study of 14000 (Berrettini et al.), CHRNA3 alleles have a odds ration of 1.3 and a p value of 1.0E-10. deCODE study in 2008 also found high association across a 60 Kb region that includes CHRNA5 and CHRNA3. Expression of alpha3 in amygdala, entorhinal cortex and nucleus accumbens likely to be most important.
Category: Genetic variation and alleles; Health and disease associations;
Expression patterns: mature cells, tissues
Add Time: 2009-07-15 10:50:21
Reason for Modification: more
Previous Version:
Gene Symbol: Chrna3
Species: mouse
Entry: Strong candidate for nicotine dependence in human association studies. In a GWAS study of 14000 (Berrettini et al.), CHRNA3 alleles have a odds ration of 1.3 and a p value of 1.0E-10. deCODE study in 2008 also found high association across a 60 Kb region that includes CHRNA5 and CHRNA3. Expression of alpha3 in amygdala, entorhinal cortex and nucleus accumbens likely to be most important.
Category: Genetic variation and alleles; Health and disease associations;
Expression patterns: mature cells, tissues
Add Time: 2009-07-15 09:11:29
Reason for Modification: more

Gene Symbol: Chrna3
Species: mouse
Entry: Nominated as candidate for nicotine dependence in human association studies.
Category: Health and disease associations
Add Time: 2007-08-10 14:06:30

CITG Web services initiated January, 1994 as Portable Dictionary of the Mouse Genome; June 15, 2001 as WebQTL; and Jan 5, 2005 as GeneNetwork. This site is currently operated by Rob Williams, Pjotr Prins, Zachary Sloan, Arthur Centeno. Design and code by Pjotr Prins, Zach Sloan, Arthur Centeno, Danny Arends, Christian Fischer, Sam Ockman, Lei Yan, Xiaodong Zhou, Christian Fernandez, Ning Liu, Rudi Alberts, Elissa Chesler, Sujoy Roy, Evan G. Williams, Alexander G. Williams, Kenneth Manly, Jintao Wang, and Robert W. Williams, colleagues. Python Powered Registered with Nif
GeneNetwork support from:
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  • NIGMS Systems Genetics and Precision Medicine project (R01 GM123489, 2017-2021)
  • NIDA NIDA Core Center of Excellence in Transcriptomics, Systems Genetics, and the Addictome (P30 DA044223, 2017-2022)
  • NIA Translational Systems Genetics of Mitochondria, Metabolism, and Aging (R01AG043930, 2013-2018)
  • NIAAA Integrative Neuroscience Initiative on Alcoholism (U01 AA016662, U01 AA013499, U24 AA013513, U01 AA014425, 2006-2017)
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  • NCI MMHCC (U01CA105417), NCRR, BIRN, (U24 RR021760)
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