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Data Set Group2: OHSU HS-CC Striatum ILM6v1 (Feb11) modify this page

Data Set: OHSU HS-CC Striatum ILM6v1 (Feb11) RankInv modify this page
GN Accession: GN304
GEO Series: No Geo series yet
Title:
Organism: Mouse (Mus musculus, mm10)
Group: HS-CC
Tissue: Striatum mRNA
Dataset Status: Public
Platforms: Illumina Mouse WG-6 v1, v1.1 (GPL6105)
Normalization: RankInv
Contact Information
Robert Hitzemann
Oregon Health & Science University
VAMC Building 101, Room 530A
Portland, OR 97239 USA
Tel. 503 402-2858
hitzeman@ohsu.edu
Website
Download datasets and supplementary data files

Specifics of this Data Set:
None

Summary:
The current study focused on the extent genetic diversity within a species (Mus musculus) affects gene co-expression network structure. To examine this issue, we have created a new mouse resource, a heterogeneous stock (HS) formed from the same eight inbred strains that have been used to create the collaborative cross (CC). The eight inbred strains capture > 90% of the genetic diversity available within the species. For contrast with the HS-CC, a C57BL/6J (B6) × DBA/2J (D2) F2 intercross and the HS4, derived from crossing the B6, D2, BALB/cJ and LP/J strains, were used. Brain (striatum) gene expression data were obtained using the Illumina Mouse WG 6.1 array, and the data sets were interrogated using a weighted gene co-expression network analysis (WGCNA).
Read full article: Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse.


About the cases used to generate this set of data:


About the tissue used to generate this set of data:


About the array platform:


About data values and data processing:


Notes:

Important links:
Compgen tool suite CC mice.
COLLABORATIVE CROSS AND DIVERSITY OUTBRED REFERENCE DATA.



Experiment Type:


Contributor:


Citation:


Data source acknowledgment:


Study Id:
105
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GeneNetwork support from:
  • The UT Center for Integrative and Translational Genomics
  • NIGMS Systems Genetics and Precision Medicine project (R01 GM123489, 2017-2021)
  • NIDA NIDA Core Center of Excellence in Transcriptomics, Systems Genetics, and the Addictome (P30 DA044223, 2017-2022)
  • NIA Translational Systems Genetics of Mitochondria, Metabolism, and Aging (R01AG043930, 2013-2018)
  • NIAAA Integrative Neuroscience Initiative on Alcoholism (U01 AA016662, U01 AA013499, U24 AA013513, U01 AA014425, 2006-2017)
  • NIDA, NIMH, and NIAAA (P20-DA 21131, 2001-2012)
  • NCI MMHCC (U01CA105417), NCRR, BIRN, (U24 RR021760)
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