Data Set Group2: HBTRC-MLC Human Cerebellum Agilent (Jun11)

Data Set: HBTRC-MLC Human Cerebellum Agilent Normal (Jun11) mlratio GN Accession: GN361 GEO Series: No Geo series yet Title: Organism: Human (Homo sapiens, hg19) Group: HB Tissue: Cerebellum mRNA Dataset Status: Public Platforms: Custom SAGE Bionetworks Agilent Array Normalization: mlratio

Contact Information Francine Benes Harvard Brain Tissue Resource Center 115 Mill Street Belmont, MA 2478 USA Tel. 1-800-272-4622 hbtrc@mclean.harvard.edu Website Download datasets and supplementary data files

Specifics of this Data Set:

None

Summary:

This study aims at identifying functional variation in the human genome (especially as it pertains to brain expressed RNAs) and elucidate its relationship to disease and drug response. The ~800 individuals in this dataset are composed of approximately 400 Alzheimers disease (AD) cases, 230 Huntington's Disease (HD) and 170 controls (N) matched for age, gender, and post mortem interval (PMI). The tissue specimens for this study were provided by Harvard Brain Tissue Resource Center (HBTRC). Three brain regions (cerebellum, visual cortex, and dorsolateral prefrontal cortex) from the same individuals were profiled on a custom-made Agilent 44K microarray of 39,280 DNA probes uniquely targeting 37,585 known and predicted genes, including splice variants, miRNAs and high-confidence non-coding RNA sequences. The individuals were genotyped on two different platforms, the Illumina HumanHap650Y array and a custom Perlegen 300K array (a focused panel for detection of singleton SNPs). Clinical outcomes available include age at onset, age at death, Braak scores (AD), Vonsattel scores (HD), Regional brain enlargement/atrophy.

About the cases used to generate this set of data:

Series Cerebellum in GN Condition Gender BioSample Name 1 HB_029_N N NA 3405_VC_N_0859 2 HB_058_N N NA 4021_VC_N_0854 3 HB_064_N N NA 4338_VC_N_0861 4 HB_086_N N NA 4729_PF_N_0756 5 HB_091_N N NA 4741_VC_N_0864 6 HB_092_N N NA 4744_VC_N_0865 7 HB_102_N N NA 4810_VC_N_0869 8 HB_119_N N NA 4872_VC_N_0878 9 HB_147_N N NA 5021_VC_N_0852 10 HB_161_N N NA 5077_VC_N_0851 11 HB_162_N N NA 5081_VC_N_1021 12 HB_166_N N NA 5095_VC_N_1024 13 HB_183_N N NA 5162_VC_N_0850 14 HB_206_N N NA 5245_VC_N_0849 15 HB_215_N N NA 5270_VC_N_0848 16 HB_218_N N NA 5276_CR_N_0912 17 HB_223_N N NA 5287_VC_N_0916 18 HB_226_N N NA 5294_VC_N_0919 19 HB_241_N N NA 5326_CR_N_0652 20 HB_243_N N NA 5333_VC_N_1262 21 HB_247_N N NA 5341_VC_N_0923 22 HB_257_N N NA 5368_PF_N_1032 23 HB_264_N N NA 5384_VC_N_0924 24 HB_295_N N NA 5452_VC_N_1268 25 HB_300_N N NA 5463_VC_N_0845 26 HB_311_N N NA 5489_CR_N_0942 27 HB_324_N N NA 5531_VC_N_0844 28 HB_332_N N NA 5547_VC_N_0843 29 HB_340_N N NA 5568_VC_N_0842 30 HB_360_N N NA 5619_CR_N_0645 31 HB_365_N N NA 5632_VC_N_0838 32 HB_367_N N NA 5637_VC_N_0837 33 HB_382_N N NA 5684_PF_N_1270 34 HB_396_N N NA 5718_VC_N_0956 35 HB_398_N N NA 5722_VC_N_1044 36 HB_400_N N NA 5726_VC_N_0834_Bis 37 HB_403_N N NA 5734_VC_N_0833 38 HB_414_N N NA 5772_VC_N_0832_Bis 39 HB_416_N N NA 5778_CR_N_0962 40 HB_418_N N NA 5789_PF_N_1273 41 HB_421_N N NA 5799_VC_N_1058 42 HB_423_N N NA 5803_VC_N_0966 43 HB_426_N N NA 5806_PF_N_1064 44 HB_427_N N NA 5810_CR_N_0636 45 HB_431_N N NA 5823_VC_N_0829 46 HB_432_N N NA 5826_VC_N_0828 47 HB_433_N N NA 5827_VC_N_0827 48 HB_436_N N NA 5832_PF_N_1145 49 HB_443_N N NA 5852_VC_N_0826 50 HB_446_N N NA 5859_VC_N_0825 51 HB_449_N N NA 5866_VC_N_0824 52 HB_450_N N NA 5867_VC_N_1277 53 HB_453_N N NA 5876_VC_N_0823 54 HB_462_N N NA 5903_VC_N_0822 55 HB_464_N N NA 5905_VC_N_0820 56 HB_468_N N NA 5912_VC_N_1286 57 HB_472_N N NA 5925_VC_N_1289 58 HB_475_N N NA 5936_VC_N_0979 59 HB_476_N N NA 5938_VC_N_0819 60 HB_480_N N NA 5946_VC_N_0985 61 HB_485_N N NA 5959_VC_N_0818 62 HB_486_N N NA 5963_VC_N_0987 63 HB_495_N N NA 5980_VC_N_0989 64 HB_497_N N NA 5985_VC_N_0990 65 HB_500_N N NA 5990_VC_N_0817 66 HB_501_N N NA 5991_VC_N_0816 67 HB_504_N N NA 5996_VC_N_0815 68 HB_505_N N NA 5998_VC_N_0814 69 HB_507_N N NA 6006_VC_N_0813 70 HB_508_N N NA 6007_CR_N_0618 71 HB_509_N N NA 6008_PF_N_1081 72 HB_512_N N NA 6023_PF_N_1155 73 HB_516_N N NA 6030_VC_N_0810 74 HB_519_N N NA 6034_VC_N_0809 75 HB_532_N N NA 6060_VC_N_1292 76 HB_541_N N NA 6092_VC_N_1001 77 HB_542_N N NA 6096_VC_N_0807 78 HB_544_N N NA 6101_CR_N_1161 79 HB_547_N N NA 6110_VC_N_1295 80 HB_551_N N NA 6124_VC_N_0806 81 HB_557_N N NA 6134_PF_N_1297 82 HB_560_N N NA 6142_VC_N_0805 83 HB_569_N N NA 6166_VC_N_0804 84 HB_570_N N NA 6170_VC_N_0803 85 HB_572_N N NA 6172_VC_N_1008 86 HB_577_N N NA 6182_VC_N_1166 87 HB_579_N N NA 6187_CR_N_0607 88 HB_581_N N NA 6191_VC_N_1010 89 HB_584_N N NA 6196_CR_N_0605 90 HB_586_N N NA 6200_VC_N_0799 91 HB_587_N N NA 6206_PF_N_1176 92 HB_589_N N NA 6213_VC_N_0798 93 HB_601_N N NA 6241_VC_N_0796 94 HB_604_N N NA 6260_VC_N_0794 95 HB_609_N N NA 6270_VC_N_0793 96 HB_618_N N NA 6289_VC_N_0791 97 HB_622_N N NA 6310_VC_N_0790 98 HB_625_N N NA 6314_VC_N_0789 99 HB_637_N N NA 6340_VC_N_0786 100 HB_638_N N NA 6341_VC_N_0785 101 HB_640_N N NA 6347_VC_N_0784 102 HB_641_N N NA 6356_VC_N_0783 103 HB_643_N N NA 6363_VC_N_0781 104 HB_644_N N NA 6366_VC_N_0780 105 HB_645_N N NA 6374_VC_N_0779 106 HB_650_N N NA 6384_VC_N_0777 107 HB_651_N N NA 6386_VC_N_0776 108 HB_653_N N NA 6388_VC_N_0775 109 HB_659_N N NA 6406_VC_N_1180 110 HB_662_N N NA 6411_VC_N_0771 111 HB_663_N N NA 6415_VC_N_0770 112 HB_670_N N NA 6436_VC_N_0769 113 HB_687_N N NA 6484_VC_N_0765 114 HB_689_N N NA 6486_VC_N_0764 115 HB_694_N N NA 6500_VC_N_0763 116 HB_697_N N NA 6512_VC_N_0762 117 HB_700_N N NA 6520_VC_N_0761 118 HB_711_N N NA 6543_PF_N_1191 119 HB_714_N N NA 6549_VC_N_1198 120 HB_717_N N NA 6553_PF_N_2284 121 HB_721_N N NA 6560_VC_N_2578 122 HB_726_N N NA 6573_PF_N_2293 123 HB_730_N N NA 6580_VC_N_2306 124 HB_735_N N NA 6588_VC_N_1213 125 HB_737_N N NA 6593_VC_N_1219 126 HB_738_N N NA 6594_VC_N_1222 127 HB_759_N N NA 6645_VC_N_1231 128 HB_764_N N NA 6655_VC_N_1240 129 HB_765_N N NA 6656_VC_N_1243 130 HB_767_N N NA 6661_PF_N_2341 131 HB_770_N N NA 6669_VC_N_1246 132 HB_772_N N NA 6676_PF_N_1248 133 HB_001_HD HD F 2028_CR_H_2282 134 HB_003_HD HD F 2685_PF_H_2212 135 HB_004_HD HD M 2706_CR_H_2432 136 HB_006_HD HD M 2737_VC_H_2194 137 HB_007_HD HD NA 2769_VC_H_2193 138 HB_008_HD HD F 2790_CR_H_1890 139 HB_009_HD HD NA 2879_VC_H_2192 140 HB_010_HD HD M 2960_VC_H_2002 141 HB_011_HD HD F 3053_VC_H_2001 142 HB_012_HD HD F 3128_VC_H_1999 143 HB_014_HD HD F 3149_PF_H_2110 144 HB_015_HD HD F 3150_VC_H_1996 145 HB_016_HD HD F 3177_VC_H_2191 146 HB_017_HD HD NA 3195_VC_H_2190 147 HB_018_HD HD M 3200_VC_H_2189 148 HB_019_HD HD M 3209_VC_H_2188 149 HB_020_HD HD M 3224_VC_H_1994 150 HB_022_HD HD F 3242_PF_H_2105 151 HB_024_HD HD NA 3272_VC_H_2186 152 HB_027_HD HD M 3356_VC_H_2439 153 HB_028_HD HD F 3394_PF_H_2104 154 HB_031_HD HD M 3430_VC_H_1990 155 HB_032_HD HD NA 3444_PF_H_2208 156 HB_034_HD HD F 3482_VC_H_1987 157 HB_036_HD HD M 3576_VC_H_1984 158 HB_037_HD HD F 3579_VC_H_1983 159 HB_038_HD HD F 3584_VC_H_2183 160 HB_039_HD HD NA 3635_VC_H_2182 161 HB_041_HD HD F 3695_CR_H_2267 162 HB_042_HD HD M 3697_VC_H_1982 163 HB_043_HD HD NA 3703_VC_H_2180 164 HB_044_HD HD NA 3723_VC_H_2179 165 HB_046_HD HD F 3735_VC_H_1981 166 HB_050_HD HD M 3820_PF_H_2207 167 HB_051_HD HD F 3849_CR_H_2262 168 HB_054_HD HD M 3884_VC_H_2175 169 HB_056_HD HD NA 4012_VC_H_2174 170 HB_057_HD HD NA 4013_VC_H_2173 171 HB_059_HD HD NA 4066_VC_H_2172 172 HB_060_HD HD NA 4094_VC_H_2171 173 HB_061_HD HD F 4116_VC_H_2170 174 HB_062_HD HD NA 4121_VC_H_2169 175 HB_063_HD HD NA 4215_VC_H_2167 176 HB_065_HD HD M 4340_PF_H_2091 177 HB_066_HD HD F 4344_VC_H_1977 178 HB_067_HD HD M 4346_VC_H_2165 179 HB_069_HD HD F 4356_VC_H_2164 180 HB_070_HD HD NA 4386_CR_H_2249 181 HB_072_HD HD NA 4404_VC_H_2161 182 HB_073_HD HD F 4411_VC_H_1975 183 HB_074_HD HD NA 4430_VC_H_2465 184 HB_075_HD HD M 4470_VC_H_1974 185 HB_076_HD HD F 4497_CR_H_1860 186 HB_077_HD HD M 4509_CR_H_2244 187 HB_079_HD HD M 4631_VC_H_1971 188 HB_080_HD HD F 4653_PF_H_2083 189 HB_081_HD HD NA 4678_CR_H_2242 190 HB_084_HD HD M 4718_VC_H_2125 191 HB_090_HD HD NA 4740_CR_H_2474 192 HB_094_HD HD NA 4754_CR_H_2476 193 HB_098_HD HD NA 4780_VC_H_2151 194 HB_101_HD HD F 4809_VC_H_2148 195 HB_105_HD HD NA 4819_CR_H_2238 196 HB_106_HD HD F 4822_VC_H_1969 197 HB_108_HD HD M 4826_VC_H_1968 198 HB_109_HD HD M 4828_VC_H_2124 199 HB_115_HD HD NA 4855_CR_H_2235 200 HB_121_HD HD F 4902_VC_H_1967 201 HB_129_HD HD NA 4938_VC_H_1966 202 HB_141_HD HD F 4996_PF_H_2076 203 HB_152_HD HD NA 5034_CR_H_2233 204 HB_153_HD HD M 5043_VC_H_1960 205 HB_159_HD HD M 5062_VC_H_1959 206 HB_172_HD HD F 5114_PF_H_2070 207 HB_175_HD HD M 5127_PF_H_2068 208 HB_180_HD HD M 5148_VC_H_1944 209 HB_185_HD HD F 5167_CR_H_2231 210 HB_188_HD HD F 5172_VC_H_1951 211 HB_191_HD HD M 5180_VC_H_1949 212 HB_196_HD HD NA 5199_PF_H_2202 213 HB_203_HD HD F 5228_PF_H_2059 214 HB_207_HD HD NA 5248_PF_H_2201 215 HB_228_HD HD F 5299_CR_H_2228 216 HB_233_HD HD M 5312_VC_H_1938 217 HB_235_HD HD F 5316_VC_H_1937 218 HB_242_HD HD F 5328_PF_H_2048 219 HB_266_HD HD M 5387_VC_H_1928 220 HB_271_HD HD M 5394_PF_H_2039 221 HB_272_HD HD F 5396_VC_H_1925 222 HB_279_HD HD F 5409_VC_H_1924 223 HB_294_HD HD M 5448_VC_H_1921 224 HB_301_HD HD NA 5464_VC_H_1919 225 HB_304_HD HD F 5471_VC_H_1918 226 HB_321_HD HD NA 5522_PF_H_2199 227 HB_361_HD HD F 5622_VC_H_2121 228 HB_370_HD HD M 5645_VC_H_1904 229 HB_371_HD HD F 5648_PF_H_2016 230 HB_384_HD HD F 5688_PF_H_2012 231 HB_390_HD HD M 5704_PF_H_2009 232 HB_393_HD HD F 5709_VC_H_1895 233 HB_402_HD HD F 5732_PF_H_2007 234 HB_405_HD HD NA 5742_PF_H_2006 235 HB_407_HD HD M 5745_PF_H_2005 236 HB_408_HD HD M 5747_VC_H_1891 237 HB_415_HD HD NA 5777_PF_H_1551 238 HB_417_HD HD M 5784_PF_H_1554 239 HB_424_HD HD M 5804_VC_H_1558 240 HB_444_HD HD M 5856_VC_H_1567 241 HB_457_HD HD M 5896_VC_H_1570 242 HB_466_HD HD M 5910_PF_H_1572 243 HB_478_HD HD M 5941_CR_H_1583 244 HB_487_HD HD F 5964_VC_H_1597 245 HB_511_HD HD M 6019_PF_H_2198 246 HB_513_HD HD F 6024_VC_H_1612 247 HB_515_HD HD F 6028_CR_H_1613 248 HB_518_HD HD M 6033_VC_H_1618 249 HB_522_HD HD M 6037_PF_H_1626 250 HB_527_HD HD F 6047_VC_H_1639 251 HB_528_HD HD M 6051_PF_H_1641 252 HB_530_HD HD M 6054_VC_H_1648 253 HB_537_HD HD F 6071_PF_H_1653 254 HB_549_HD HD M 6119_CR_H_1670 255 HB_593_HD HD NA 6219_CR_H_2567 256 HB_610_HD HD NA 6275_PF_H_1692 257 HB_616_HD HD F 6284_CR_H_1694 258 HB_626_HD HD M 6315_VC_H_1702 259 HB_639_HD HD F 6344_CR_H_1703 260 HB_649_HD HD F 6382_CR_H_1709 261 HB_661_HD HD M 6408_VC_H_1714 262 HB_682_HD HD M 6467_PF_H_1725 263 HB_683_HD HD M 6472_VC_H_1729 264 HB_691_HD HD F 6493_VC_H_1732 265 HB_692_HD HD M 6495_CR_H_1733 266 HB_707_HD HD M 6535_PF_H_1737 267 HB_709_HD HD F 6539_CR_H_1739 268 HB_725_HD HD M 6572_PF_H_1746 269 HB_732_HD HD F 6584_VC_H_1750 270 HB_734_HD HD F 6587_CR_H_1751 271 HB_748_HD HD NA 6615_VC_H_2315 272 HB_750_HD HD NA 6628_PF_H_2326 273 HB_758_HD HD NA 6643_VC_H_2602 274 HB_760_HD HD M 6646_PF_H_1761 275 HB_762_HD HD M 6650_VC_H_1765 276 HB_766_HD HD M 6658_VC_H_1768 277 HB_768_HD HD NA 6663_VC_H_1771 278 HB_769_HD HD M 6666_VC_H_1774 279 HB_774_HD HD NA 6689_PF_H_2344 280 HB_778_HD HD NA 6696_PF_H_2356 281 HB_780_HD HD NA 6704_PF_H_2362 282 HB_790_HD HD NA 6788_PF_H_2389 283 HB_800_HD HD NA 6807_PF_H_2419 284 HB_802_HD HD NA 6811_PF_H_2425 285 HB_045_AD AD NA 3734_CR_A_0122 286 HB_048_AD AD NA 3791_CR_A_0128 287 HB_053_AD AD NA 3877_CR_A_0134 288 HB_055_AD AD NA 3893_VC_A_0142 289 HB_068_AD AD NA 4349_VC_A_0148 290 HB_082_AD AD NA 4712_CR_A_0309 291 HB_085_AD AD NA 4726_VC_A_0311 292 HB_087_AD AD NA 4730_CR_A_0315 293 HB_089_AD AD NA 4733_VC_A_0320 294 HB_093_AD AD NA 4749_VC_A_0323 295 HB_095_AD AD NA 4759_CR_A_0327 296 HB_097_AD AD NA 4773_CR_A_0866 297 HB_099_AD AD NA 4785_VC_A_0332 298 HB_100_AD AD NA 4795_VC_A_0335 299 HB_103_AD AD NA 4811_VC_A_0341 300 HB_104_AD AD NA 4813_CR_A_0345 301 HB_112_AD AD NA 4842_VC_A_0870 302 HB_113_AD AD NA 4850_CR_A_0351 303 HB_114_AD AD NA 4852_CR_A_0354 304 HB_117_AD AD NA 4868_VC_A_0874 305 HB_122_AD AD NA 4904_CR_A_1132 306 HB_123_AD AD NA 4905_VC_A_0884 307 HB_124_AD AD NA 4916_VC_A_0886 308 HB_125_AD AD NA 4917_CR_A_0360 309 HB_126_AD AD NA 4921_VC_A_0362 310 HB_128_AD AD NA 4936_CR_A_0369 311 HB_130_AD AD NA 4939_VC_A_0888 312 HB_131_AD AD NA 4944_CR_A_0889 313 HB_132_AD AD NA 4946_CR_A_0372 314 HB_134_AD AD NA 4951_CR_A_0891 315 HB_135_AD AD NA 4953_VC_A_0893 316 HB_136_AD AD NA 4965_VC_A_0160 317 HB_137_AD AD NA 4966_VC_A_0374 318 HB_138_AD AD NA 4969_VC_A_0895 319 HB_140_AD AD NA 4993_CR_A_0896 320 HB_146_AD AD NA 5018_CR_A_0384 321 HB_148_AD AD NA 5022_VC_A_0386 322 HB_150_AD AD NA 5031_VC_A_0392 323 HB_151_AD AD NA 5033_CR_A_0396 324 HB_154_AD AD NA 5048_VC_A_1321 325 HB_155_AD AD NA 5056_VC_A_0398 326 HB_156_AD AD NA 5057_VC_A_0163 327 HB_157_AD AD NA 5059_VC_A_0401 328 HB_158_AD AD NA 5061_PF_A_2612 329 HB_160_AD AD NA 5064_PF_A_2615 330 HB_165_AD AD NA 5092_CR_A_0899 331 HB_168_AD AD NA 5097_VC_A_0407 332 HB_170_AD AD NA 5101_VC_A_0410 333 HB_174_AD AD NA 5124_PF_A_1343 334 HB_179_AD AD NA 5145_VC_A_1351 335 HB_181_AD AD NA 5152_CR_A_0414 336 HB_184_AD AD NA 5166_VC_A_1354 337 HB_194_AD AD NA 5193_VC_A_1360 338 HB_197_AD AD NA 5202_CR_A_1368 339 HB_199_AD AD NA 5205_VC_A_0166 340 HB_200_AD AD NA 5210_VC_A_0905 341 HB_205_AD AD NA 5235_VC_A_0419 342 HB_208_AD AD NA 5249_VC_A_0422 343 HB_209_AD AD NA 5252_VC_A_0907 344 HB_211_AD AD NA 5257_VC_A_0169 345 HB_216_AD AD NA 5272_VC_A_0425 346 HB_219_AD AD NA 5279_CR_A_0147 347 HB_221_AD AD NA 5283_VC_A_0145 348 HB_222_AD AD NA 5285_VC_A_0141 349 HB_224_AD AD NA 5288_VC_A_0428 350 HB_230_AD AD NA 5301_VC_A_0174 351 HB_231_AD AD NA 5305_VC_A_1384 352 HB_232_AD AD NA 5310_CR_A_0176 353 HB_234_AD AD NA 5313_PF_A_2618 354 HB_236_AD AD NA 5317_PF_A_2624 355 HB_238_AD AD NA 5322_CR_A_2632 356 HB_240_AD AD NA 5325_VC_A_0137 357 HB_244_AD AD NA 5337_VC_A_1387 358 HB_245_AD AD NA 5339_VC_A_0181 359 HB_250_AD AD NA 5346_VC_A_1393 360 HB_251_AD AD NA 5350_VC_A_0184 361 HB_252_AD AD NA 5355_VC_A_0133 362 HB_253_AD AD NA 5359_CR_A_1395 363 HB_258_AD AD NA 5370_PF_A_1400 364 HB_259_AD AD NA 5371_PF_A_2636 365 HB_260_AD AD NA 5375_VC_A_0188 366 HB_263_AD AD NA 5381_VC_A_0022 367 HB_265_AD AD NA 5385_VC_A_1402 368 HB_267_AD AD NA 5389_VC_A_0928 369 HB_268_AD AD NA 5390_CR_A_0151 370 HB_273_AD AD NA 5400_PF_A_2645 371 HB_274_AD AD NA 5401_VC_A_0931 372 HB_275_AD AD NA 5404_PF_A_2648 373 HB_276_AD AD NA 5406_VC_A_0933 374 HB_277_AD AD NA 5407_PF_A_2651 375 HB_280_AD AD NA 5412_VC_A_0935 376 HB_281_AD AD NA 5413_PF_A_2657 377 HB_283_AD AD NA 5419_VC_A_0937 378 HB_284_AD AD NA 5420_VC_A_0939 379 HB_285_AD AD NA 5421_CR_A_0432 380 HB_286_AD AD NA 5423_PF_A_2660 381 HB_288_AD AD NA 5425_PF_A_2666 382 HB_289_AD AD NA 5426_VC_A_1405 383 HB_290_AD AD NA 5433_VC_A_0434 384 HB_296_AD AD NA 5456_PF_A_2675 385 HB_299_AD AD NA 5461_VC_A_0192 386 HB_302_AD AD NA 5465_PF_A_2678 387 HB_303_AD AD NA 5469_VC_A_1417 388 HB_305_AD AD NA 5479_PF_A_1421 389 HB_306_AD AD NA 5480_VC_A_0437 390 HB_307_AD AD NA 5482_VC_A_0028 391 HB_308_AD AD NA 5483_VC_A_0941 392 HB_309_AD AD NA 5487_CR_A_0441 393 HB_310_AD AD NA 5488_CR_A_0194 394 HB_312_AD AD NA 5500_VC_A_0198 395 HB_313_AD AD NA 5502_PF_A_2684 396 HB_315_AD AD NA 5513_PF_A_2687 397 HB_316_AD AD NA 5516_PF_A_2690 398 HB_317_AD AD NA 5517_PF_A_2693 399 HB_318_AD AD NA 5518_CR_A_0030 400 HB_319_AD AD NA 5519_CR_A_2695 401 HB_320_AD AD NA 5520_PF_A_2699 402 HB_322_AD AD NA 5527_VC_A_0945 403 HB_325_AD AD NA 5532_PF_A_2702 404 HB_328_AD AD NA 5541_PF_A_2705 405 HB_330_AD AD NA 5544_VC_A_0201 406 HB_334_AD AD NA 5554_VC_A_0452 407 HB_335_AD AD NA 5557_VC_A_0950 408 HB_337_AD AD NA 5560_VC_A_0204 409 HB_342_AD AD NA 5571_PF_A_1430 410 HB_345_AD AD NA 5583_PF_A_2708 411 HB_347_AD AD NA 5589_PF_A_2714 412 HB_349_AD AD NA 5592_PF_A_2717 413 HB_352_AD AD NA 5604_VC_A_0037 414 HB_353_AD AD NA 5607_PF_A_2723 415 HB_356_AD AD NA 5615_VC_A_0041 416 HB_357_AD AD NA 5616_CR_A_0127 417 HB_358_AD AD NA 5617_CR_A_0456 418 HB_359_AD AD NA 5618_CR_A_0044 419 HB_362_AD AD NA 5625_CR_A_2495 420 HB_363_AD AD NA 5626_CR_A_2498 421 HB_364_AD AD NA 5629_CR_A_0390 422 HB_369_AD AD NA 5643_VC_A_1143 423 HB_373_AD AD NA 5654_VC_A_0047 424 HB_375_AD AD NA 5660_CR_A_0462 425 HB_376_AD AD NA 5661_VC_A_0464 426 HB_377_AD AD NA 5667_VC_A_2509 427 HB_378_AD AD NA 5668_VC_A_1438 428 HB_383_AD AD NA 5686_CR_A_2728 429 HB_386_AD AD NA 5695_VC_A_0953 430 HB_389_AD AD NA 5700_VC_A_2514 431 HB_391_AD AD NA 5705_CR_A_0474 432 HB_392_AD AD NA 5706_VC_A_0476 433 HB_394_AD AD NA 5713_VC_A_0479 434 HB_397_AD AD NA 5721_CR_A_0210 435 HB_404_AD AD NA 5735_CR_A_0489 436 HB_406_AD AD NA 5744_CR_A_0960 437 HB_409_AD AD NA 5749_CR_A_0159 438 HB_410_AD AD NA 5751_CR_A_2518 439 HB_411_AD AD NA 5755_CR_A_2731 440 HB_413_AD AD NA 5766_VC_A_0214 441 HB_419_AD AD NA 5790_VC_A_0217 442 HB_420_AD AD NA 5796_CR_A_0964 443 HB_428_AD AD NA 5811_CR_A_2524 444 HB_429_AD AD NA 5819_CR_A_2527 445 HB_430_AD AD NA 5822_CR_A_2530 446 HB_434_AD AD NA 5828_CR_A_2533 447 HB_435_AD AD NA 5831_CR_A_0222 448 HB_437_AD AD NA 5839_CR_A_2539 449 HB_438_AD AD NA 5843_CR_A_0227 450 HB_439_AD AD NA 5845_CR_A_0230 451 HB_441_AD AD NA 5849_CR_A_0233 452 HB_442_AD AD NA 5850_CR_A_0495 453 HB_445_AD AD NA 5858_CR_A_0969 454 HB_448_AD AD NA 5864_CR_A_0974 455 HB_451_AD AD NA 5871_CR_A_2542 456 HB_454_AD AD NA 5879_CR_A_2545 457 HB_455_AD AD NA 5887_CR_A_0976_Bis 458 HB_459_AD AD NA 5898_CR_A_2548 459 HB_460_AD AD NA 5900_VC_A_0237 460 HB_461_AD AD NA 5901_CR_A_0239 461 HB_469_AD AD NA 5914_CR_A_2554 462 HB_471_AD AD NA 5922_VC_A_0246 463 HB_473_AD AD NA 5927_CR_A_2560 464 HB_474_AD AD NA 5933_VC_A_1071 465 HB_477_AD AD NA 5939_CR_A_1151 466 HB_479_AD AD NA 5945_VC_A_0983 467 HB_484_AD AD NA 5956_CR_A_0123 468 HB_489_AD AD NA 5968_VC_A_1075 469 HB_491_AD AD NA 5971_CR_A_0119 470 HB_492_AD AD NA 5972_VC_A_0251 471 HB_494_AD AD NA 5979_CR_A_0115 472 HB_498_AD AD NA 5988_VC_A_0503 473 HB_502_AD AD NA 5994_PF_A_1605 474 HB_503_AD AD NA 5995_CR_A_2563 475 HB_510_AD AD NA 6017_CR_A_0048 476 HB_514_AD AD NA 6025_VC_A_0506 477 HB_517_AD AD NA 6031_VC_A_0258 478 HB_520_AD AD NA 6035_VC_A_1621 479 HB_523_AD AD NA 6038_VC_A_0261 480 HB_524_AD AD NA 6042_VC_A_1156 481 HB_525_AD AD NA 6044_VC_A_0264 482 HB_531_AD AD NA 6056_CR_A_0999 483 HB_533_AD AD NA 6061_PF_A_1650 484 HB_534_AD AD NA 6066_VC_A_0270 485 HB_535_AD AD NA 6067_PF_A_1452 486 HB_536_AD AD NA 6068_VC_A_0273 487 HB_545_AD AD NA 6102_CR_A_1661 488 HB_546_AD AD NA 6107_CR_A_0055 489 HB_550_AD AD NA 6120_VC_A_0058 490 HB_552_AD AD NA 6126_VC_A_1675 491 HB_553_AD AD NA 6129_PF_A_0274 492 HB_554_AD AD NA 6130_VC_A_1678 493 HB_555_AD AD NA 6131_CR_A_0510 494 HB_556_AD AD NA 6132_CR_A_0513 495 HB_558_AD AD NA 6137_VC_A_1681 496 HB_564_AD AD NA 6153_VC_A_1465 497 HB_565_AD AD NA 6154_VC_A_1468 498 HB_566_AD AD NA 6157_VC_A_0062 499 HB_568_AD AD NA 6164_CR_A_1005 500 HB_571_AD AD NA 6171_CR_A_0065 501 HB_573_AD AD NA 6174_VC_A_0068 502 HB_576_AD AD NA 6180_CR_A_0281 503 HB_583_AD AD NA 6194_VC_A_0071 504 HB_585_AD AD NA 6198_VC_A_0073 505 HB_590_AD AD NA 6215_VC_A_0518 506 HB_591_AD AD NA 6216_VC_A_1476 507 HB_592_AD AD NA 6218_CR_A_0522 508 HB_594_AD AD NA 6223_VC_A_0288 509 HB_596_AD AD NA 6226_CR_A_0076 510 HB_597_AD AD NA 6227_VC_A_0080 511 HB_598_AD AD NA 6231_VC_A_1479 512 HB_605_AD AD NA 6261_VC_A_0084 513 HB_608_AD AD NA 6268_CR_A_0525 514 HB_611_AD AD NA 6279_VC_A_0089 515 HB_612_AD AD NA 6280_VC_A_0091 516 HB_613_AD AD NA 6281_CR_A_0528 517 HB_621_AD AD NA 6308_VC_A_1503 518 HB_623_AD AD NA 6311_CR_A_0531 519 HB_624_AD AD NA 6312_CR_A_0534 520 HB_630_AD AD NA 6324_PF_A_1514 521 HB_633_AD AD NA 6332_VC_A_1518 522 HB_634_AD AD NA 6335_VC_A_0536 523 HB_635_AD AD NA 6336_CR_A_0290 524 HB_636_AD AD NA 6338_VC_A_0539 525 HB_642_AD AD NA 6358_VC_A_0545 526 HB_652_AD AD NA 6387_VC_A_0093 527 HB_657_AD AD NA 6394_VC_A_0551 528 HB_664_AD AD NA 6416_VC_A_1095 529 HB_666_AD AD NA 6422_CR_A_0555 530 HB_669_AD AD NA 6431_VC_A_0294 531 HB_674_AD AD NA 6449_VC_A_1183 532 HB_680_AD AD NA 6458_CR_A_2570 533 HB_685_AD AD NA 6481_VC_A_0560 534 HB_690_AD AD NA 6489_CR_A_0100 535 HB_696_AD AD NA 6511_VC_A_1119 536 HB_698_AD AD NA 6515_CR_A_0564 537 HB_699_AD AD NA 6518_VC_A_0103 538 HB_703_AD AD NA 6523_VC_A_0107 539 HB_704_AD AD NA 6530_VC_A_0112 540 HB_706_AD AD NA 6534_VC_A_0306 541 HB_712_AD AD NA 6546_PF_A_1194 542 HB_713_AD AD NA 6548_PF_A_1541 543 HB_715_AD AD NA 6550_VC_A_1201 544 HB_718_AD AD NA 6554_PF_A_1203 545 HB_720_AD AD NA 6559_PF_A_2287 546 HB_722_AD AD NA 6561_CR_A_2582 547 HB_723_AD AD NA 6562_PF_A_2290 548 HB_724_AD AD NA 6564_CR_A_2585 549 HB_727_AD AD NA 6575_CR_A_2298 550 HB_728_AD AD NA 6577_PF_A_2299 551 HB_729_AD AD NA 6578_PF_A_2302 552 HB_731_AD AD NA 6582_VC_A_1207 553 HB_733_AD AD NA 6585_VC_A_1210 554 HB_736_AD AD NA 6590_PF_A_1215 555 HB_743_AD AD NA 6603_PF_A_1448 556 HB_745_AD AD NA 6610_PF_A_1227 557 HB_746_AD AD NA 6612_PF_A_2308 558 HB_749_AD AD NA 6617_VC_A_2587 559 HB_751_AD AD NA 6629_VC_A_2330 560 HB_752_AD AD NA 6630_VC_A_2590 561 HB_753_AD AD NA 6632_PF_A_2332 562 HB_754_AD AD NA 6637_VC_A_2596 563 HB_755_AD AD NA 6638_VC_A_2599 564 HB_756_AD AD NA 6639_VC_A_2336 565 HB_757_AD AD NA 6641_PF_A_2338 566 HB_763_AD AD NA 6654_VC_A_1237 567 HB_773_AD AD NA 6681_VC_A_1252 568 HB_775_AD AD NA 6693_VC_A_2348 569 HB_776_AD AD NA 6694_VC_A_2351 570 HB_777_AD AD NA 6695_PF_A_2353 571 HB_779_AD AD NA 6699_PF_A_2359 572 HB_781_AD AD NA 6708_VC_A_2366 573 HB_782_AD AD NA 6776_PF_A_2607 574 HB_783_AD AD NA 6778_PF_A_2368 575 HB_784_AD AD NA 6779_PF_A_2371 576 HB_785_AD AD NA 6780_PF_A_2374 577 HB_786_AD AD NA 6782_PF_A_2377 578 HB_787_AD AD NA 6784_PF_A_2380 579 HB_788_AD AD NA 6785_CR_A_2385 580 HB_789_AD AD NA 6787_CR_A_2388 581 HB_791_AD AD NA 6790_PF_A_2392 582 HB_792_AD AD NA 6791_PF_A_2395 583 HB_793_AD AD NA 6793_PF_A_2398 584 HB_794_AD AD NA 6794_PF_A_2401 585 HB_795_AD AD NA 6797_PF_A_2404 586 HB_796_AD AD NA 6798_PF_A_2407 587 HB_797_AD AD NA 6799_VC_A_2411 588 HB_798_AD AD NA 6801_VC_A_2414 589 HB_799_AD AD NA 6803_VC_A_2417 590 HB_801_AD AD NA 6809_PF_A_2422 591 HB_803_AD AD NA 6818_CR_A_2430

About the tissue used to generate this set of data:

About the array platform:

About data values and data processing:

Notes:

Species: Human Tissue: Brain visual cortex,Brain cerebellum,Brain prefrontal cortex Disease: Neurological Disease Investigator: Francine Benes/ Eric Schadt Institution: Harvard Brain Tissue Resource Center/ Merck Research Laboratories Approximate Number Subjects: 803

Experiment Type:

This data packet contains genotypes, clinical traits, as well as expression traits measured in three regions of the brain: visual cortex, cerebellum, prefrontal cortex. Samples were collected from 803 participants including 388 diagnosed with Alzheimer's disease and 220 diagnosed with Huntington's disease. Genotypes were run using two platforms (Illumina and Perlagen). Expression traits were profiled using a custom Agilent platform. Western-IRB has confirmed that this dataset residing in Sage Bionetworks Repository is 'exempt' under federal regulation 45 CFR 46.101(b)4 and does not involve human subject research as defined by OHRP guidelines.

Contributor:

Citation:

Data source acknowledgment:

The Harvard Brain dataset was contributed by Merck Pharmaceutical through the Sage Bionetworks Repository. The tissues were provided by Harvard Brain Tissue Resource Center which is supported in part by PHS grant R24 MH068855 (http://www.brainbank.mclean.org/).

Study Id:

110

• The UT Center for Integrative and Translational Genomics
• NIGMS Systems Genetics and Precision Medicine project (R01 GM123489, 2017-2021)
• NIDA NIDA Core Center of Excellence in Transcriptomics, Systems Genetics, and the Addictome (P30 DA044223, 2017-2022)
• NIA Translational Systems Genetics of Mitochondria, Metabolism, and Aging (R01AG043930, 2013-2018)
• NIAAA Integrative Neuroscience Initiative on Alcoholism (U01 AA016662, U01 AA013499, U24 AA013513, U01 AA014425, 2006-2017)
• NIDA, NIMH, and NIAAA (P20-DA 21131, 2001-2012)
• NCI MMHCC (U01CA105417), NCRR, BIRN, (U24 RR021760)