Data Set Group2: JAX Retina (Apr18) RNA-Seq
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| Contact Information |
Pete Williams
The Jackson Laboratory
600 Main Street
Bar Harbor, Maine 04609 USA
Tel. 207-288-1472
pete.williams@jax.org
Website
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| Download datasets and supplementary data files |
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| Specifics of this Data Set: |
| RNA-Seq log2 Z-Score
In general, the array data that we put in GeneNetwork has been logged and then z normalized, but instead of leaving the mean at 0 and the standard deviation of 1 unit, we shift up to a mean of 8 units and increase the spread by having an standard deviation of 2 units (what we call 2Z + 8 normalized data). This removes negative values from the tables.
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| Summary: |
| RNA-seq analysis from young and pre-glaucomatous DBA/2J retinal ganglion cells and control (age and sex-matched, D2-Gpnmb+) retinal ganglion cells
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| About the cases used to generate this set of data: |
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| About the tissue used to generate this set of data: |
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| About the array platform: |
| GPL17021Illumina HiSeq 2500 (Mus musculus)
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| About data values and data processing: |
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| Notes: |
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| Experiment Type: |
| Retinal ganglion cell mRNA from 4 month (young) and 9 month (pre-glaucomatous) DBA/2J mice and age and sex-matched D2-Gpnmb+ controls
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| Contributor: |
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| Citation: |
- Williams PA, Harder JM, Foxworth NE, Cochran KE et al. Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 2017 Feb 17;355(6326):756-760. PMID: 28209901
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| Data source acknowledgment: |
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| Study Id: |
275
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GeneNetwork support from:
- The UT Center for Integrative and Translational Genomics
- NIGMS Systems Genetics and Precision Medicine project (R01 GM123489, 2017-2021)
- NIDA NIDA Core Center of Excellence in Transcriptomics, Systems Genetics,
and the Addictome (P30 DA044223, 2017-2022)
- NIA Translational Systems Genetics of Mitochondria, Metabolism, and Aging (R01AG043930, 2013-2018)
- NIAAA Integrative Neuroscience Initiative on Alcoholism (U01 AA016662, U01 AA013499, U24 AA013513, U01 AA014425, 2006-2017)
- NIDA, NIMH, and NIAAA (P20-DA 21131, 2001-2012)
- NCI MMHCC (U01CA105417), NCRR, BIRN, (U24 RR021760)
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