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GeneWiki Entries

GeneWiki enables you to enrich the annotation of genes and transcripts. Please submit or edit a GeneWiki note (500 characters max) related to a gene, its transcripts, or proteins. When possible include PubMed identifiers or web resource links (URL addresses). Please ensure that the additions will have widespread use. For additional information, check the GeneWiki help document.

GeneWiki for CHRNA3:

GeneNetwork:
 1.

Generally light expression in the ABA. High in the habenula and the superficial and intermediate layers of the superior colliculus.

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 2.

Possible transQTL ILRS of 15, high B6 allele) on Chr 10 (92 to 103 Mb) in SNP-sparse region using Hippocampus Consortium M430v2 (Jun06) PDNN Trait ID: 1455931_at.

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 3.

Strong candidate for nicotine dependence in human association studies. In a GWAS study of 14000 (Berrettini et al.), CHRNA3 alleles have a odds ration of 1.3 and a p value of 1.0E-10. deCODE study in 2008 also found high association across a 60 Kb region that includes CHRNA5 and CHRNA3. Expression of alpha3 in amygdala, entorhinal cortex and nucleus accumbens likely to be most important. URL Link

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 4.

Strong cis eQTL in BLA using Trait ID 10593756 from INIA Amygdala BLA Affy MoGene 1.0 ST (Nov10). LRS of 21 with high B allele. Higher expression in BLA associated with lower acute functional tolerance to ethanol (see BXD trait 10348 by Kirstein et al. 2002)

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GeneRIF from NCBI:
 1.

functional nicotinic ACh receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10 (Mus musculus) PubMed

 2.

alpha3beta2 nicotinic receptor has a role in regulating gene expression after tobacco exposure in oral epithelial cells (Mus musculus) PubMed

 3.

Fast synaptic transmission in mammalian sympathetic ganlia requires alpha3 expression; in knockout mice, the preganglionic nerve forms synapses that appear morphologically normal and persist for several weeks. (Mus musculus) PubMed

 4.

Reporter gene analysis demonstrated that this sequence, termed "alpha3 intron 5," inhibits the transcriptional activities of the alpha3 and beta4 subunit gene promoters (Mus musculus) PubMed

 5.

Our results suggest that PrP(C) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR. (Mus musculus) PubMed

 6.

The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys residues on the alpha3 subunit (Mus musculus) PubMed

 7.

Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles. (Mus musculus) PubMed

 8.

Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated. (Mus musculus) PubMed

 9.

A mechanistic model provides sharpening of mitral cell receptive fields by activation of the alpha3beta4 subtype of nicotinic receptor, which could aid in odor discrimination and perceptual learning. (Mus musculus) PubMed

 10.

findings suggest an important role for the a3b4* nAChR subtype in nicotine reward and physical aspects of the nicotine withdrawal syndrome. (Mus musculus) PubMed

 11.

Downregulation of nAChR subunit and PSD-93 expression after cavernous nerve injury, or even manipulation, could interrupt synaptic transmission within the MPG and thus contribute to the loss of neural control of urogenital organs after pelvic surgeries. (Mus musculus) PubMed

 12.

The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR containing the alpha3-subunit. (Mus musculus) PubMed

 13.

The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine (Mus musculus) PubMed

 14.

neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease (Mus musculus) PubMed

 15.

Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons. (Mus musculus) PubMed

 16.

Immunocytochemistry revealed most chromaffin cells positive for alpha3 proteins. And suggest that the most frequently encountered receptors of rat chromaffin cells should comprise alpha3beta4, alpha3beta2 with the addition of alpha5 subunits. (Rattus norvegicus) PubMed

 17.

Increased expression of the alpha 3 nicotinic receptor subunit may contribute to the mechanical hypersensitivity observed following spinal nerve ligation. (Rattus norvegicus) PubMed

 18.

In living cells the heteropentameric alpha3-beta4 nicotinic receptors are mainly distributed in the endoplasmic reticulum. (Rattus norvegicus) PubMed

 19.

analysis of nicotinic acetylcholine receptor subunit binding to 4/7 alpha-conotoxins (Rattus norvegicus) PubMed

 20.

Alpha3beta4 nicotinic receptors are neede for sympathetic nerve discharge in the thoracic spinal cord. Nicotinic activation of glycinergic & GABAergic interneurons may provide recurrent inhibition of SPNs for homeostatic regulation of sympathetic outflow. (Rattus norvegicus) PubMed

 21.

Calcium-imaging and double-labeling immunofluorescence with alpha-subunit-specific antibodies, in combination with markers for nociceptive neurons are examined. (Rattus norvegicus) PubMed

 22.

The role of negatively charged amino acids in the F-loop of the beta 4 subunit in channel activation and desensitization was studied using the patch-clamp technique. (Rattus norvegicus) PubMed

 23.

side chain volume at position L8 affected ion channel function and the pharmacological profile of neuronal 3 nAChR subtypes. (Rattus norvegicus) PubMed

 24.

These studies identify alpha3beta4 and alpha3beta3beta4, transported from the Hb and highly enriched in the IPn, as the subtypes modulating ACh release in the IPn. (Rattus norvegicus) PubMed

 25.

determined the site specificity for Mor potentiation by studying differences in modulation between alpha3beta2 and alpha4beta2 receptors (Rattus norvegicus) PubMed

 26.

Positional scanning mutagenesis of alpha-conotoxin PeIA identifies critical residues that confer potency and selectivity for alpha6/alpha3beta2beta3 and alpha3beta2 nicotinic acetylcholine receptors (Rattus norvegicus) PubMed

 27.

Data indicate that the affinity of alpha-CTxLvIA selectively blocks alpha3beta2 vs. alpha6/alpha3beta2beta3 nicotinic acetylcholine receptors. (Rattus norvegicus) PubMed

 28.

The sympathetic neuronal calcium influx through L-type calcium channels is modulated by alpha3beta2-nAChRs (Rattus norvegicus) PubMed

 29.

Results suggest the fast nAChR current in cutaneous dorsal root ganglia neurons was carried by homomeric alpha7 nAChRs while the slow current was carried by heteromeric (most likely alpha3beta4) nAChRs (Rattus norvegicus) PubMed

 30.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 31.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 32.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 33.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed

 34.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 35.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 36.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 37.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 38.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 39.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 40.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 41.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed

 42.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 43.

Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) (Homo sapiens) PubMed

 44.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 45.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 46.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 47.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 48.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 49.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 50.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 51.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 52.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 53.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 54.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) (Homo sapiens) PubMed

 55.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 56.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 57.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed

 58.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 59.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 60.

Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. (Homo sapiens) PubMed

 61.

CHRNA3 and CHRNA4 genes and AD. Two novel missense point mutations, Ser413Leu in the CHRNA4 gene and Gln397Pro in the CHRNB2 gene, were identified in two different AD cases but were not found in other AD cases and controls. (Homo sapiens) PubMed

 62.

CHRNA3 subunit is expressed in the soma of the majority of pyramidal cells, with the most alpha 3 immunoreactivity observed in CA2-4 and entorhinal cortex and relatively less in CA1 and subicular pyramidal cell soma. (Homo sapiens) PubMed

 63.

absence of differences in the pharmacological profile of nicotinic receptor alpha3beta4 argues against role for incorporated beta3 subunit in formation of agonist binding sites while changes in channel kinetics suggest important effect on receptor gating (Homo sapiens) PubMed

 64.

alpha3 and alpha7 nicotinic acetylcholine receptors regulate keratinocyte chemokinesis and chemotaxis (Homo sapiens) PubMed

 65.

alpha3beta2 nicotinic receptor has a role in regulating gene expression after tobacco exposure in oral epithelial cells (Homo sapiens) PubMed

 66.

the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins. (Homo sapiens) PubMed

 67.

Reporter gene analysis demonstrated that this sequence, termed "alpha3 intron 5," inhibits the transcriptional activities of the alpha3 and beta4 subunit gene promoters (Homo sapiens) PubMed

 68.

A common haplotype in the CHRNA5/CHRNA3 gene cluster on chromosome 15 contains alleles, which predispose to nicotine dependence. (Homo sapiens) PubMed

 69.

CHRNA5 and CHRNA3 are promising candidate genes in the region of 15q25.1 for lung cancer. (Homo sapiens) PubMed

 70.

In the 2,827 long-term smokers examined, common susceptibility and protective haplotypes at the CHRNA5-A3-B4 locus were associated with nicotine dependence severity. (Homo sapiens) PubMed

 71.

alpha3 nAChR may improve cleavage of APP by alpha-secretase, enhance antioxidation and inhibit the toxicity of Abeta, suggesting that the receptor might play an important role in AD. (Homo sapiens) PubMed

 72.

Correlated SNPs in the cholinergic nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4, in a case-control study of cocaine dependence composed of 504 European-American and 583 African-Americans. (Homo sapiens) PubMed

 73.

CHRNA3 seem to exert no relevant influence on smoking cessation probability in heavy smokers in the general population. (Homo sapiens) PubMed

 74.

smokers who carry the CHRNA3 and CHRNA5 variants are expected to be at increased risk for lung cancer compared with smokers who do not carry these alleles. (Homo sapiens) PubMed

 75.

Two distinct variant groups in the CHRNA5-CHRNA3-CHRNB4 gene cluster are strongly associated with heavy smoking. The snp rs16969968 alters the coding sequence of these genes. (Homo sapiens) PubMed

 76.

The alpha5 and alpha3 subunits play a significant role in both nicotine dependence and alcohol abuse/dependence. (Homo sapiens) PubMed

 77.

The CHRNA 3/5 and the HHIP loci make a significant contribution to the risk of COPD. (Homo sapiens) PubMed

 78.

Genetic variant in the CHRNA5-CHRNA3-CHRNB4 gene cluster is associated with smoking cessation during pregnancy. (Homo sapiens) PubMed

 79.

The detection of alpha3-AChR autoantibody aids the diagnosis of neurological autoimmunity and cancer. (Homo sapiens) PubMed

 80.

Missense mutation of CHRNB4, CHRNB3 and CHRNA4 are associated with sporadic amyotrophic lateral sclerosis. (Homo sapiens) PubMed

 81.

Genetic variation at CHRNA5/CHRNA3/CHRNB4 cluster influences blood nicotine level. (Homo sapiens) PubMed

 82.

The CHRNA3 SNP rs578776 is associated with nicotine dependence in European-Americans but not in African-Americans (Homo sapiens) PubMed

 83.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 84.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 85.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 86.

Loop 9 has a different role in the function of homomeric and heteromeric receptors. (Homo sapiens) PubMed

 87.

Single Nucleotide Polymorphism in CHRNA3 is associated with non-small cell lung cancer. (Homo sapiens) PubMed

 88.

These results indicate that variants within CHRNA3 and among CHRNA5, CHRNA3, and CHRNB4 contribute significantly to the etiology of ND through gene-gene interactions. (Homo sapiens) PubMed

 89.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 90.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 91.

Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 92.

Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 93.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 94.

These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia. (Homo sapiens) PubMed

 95.

Single nucleotide polymorphisms in the CHRNA3 gene is associated with lung cancer. (Homo sapiens) PubMed

 96.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 97.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 98.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 99.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 100.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 101.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 102.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 103.

Clinical trial of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 104.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 105.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 106.

single nucleotide polymorphisms influence treatment outcome in advanced non-small-cell lung cancer patients (Homo sapiens) PubMed

 107.

findings suggest that both CHNA5 Asp398Asn and CHRNA3 rs578776 are associated with smoking. (Homo sapiens) PubMed

 108.

The data of this study supported the importance of variants in the CHRNA5/A3/B4 gene cluster as mediators of the genetic risk for substance dependence. (Homo sapiens) PubMed

 109.

associations of variants in the CHRNA5/A3/B4 cluster with smoking initiation, smoking quantity and smoking cessation (Homo sapiens) PubMed

 110.

Data suggest that interactions between alpha3beta4 nAChRs and P2X2 receptors may modulate transmission at enteric synapses that use ATP and acetylcholine as co-transmitters. (Homo sapiens) PubMed

 111.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 112.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 113.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 114.

Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed

 115.

Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) (Homo sapiens) PubMed

 116.

The CHRNA3/5 locus was associated with increased smoking intensity and emphysema in individuals with COPD (Homo sapiens) PubMed

 117.

evidence that CHRNA5-CHRNA3-CHRNB4 gene cluster variants,particularly CHRNA5 variant rs16969968, could be associated with cognitive performance possibly mediating in part risk for developing nicotine dependence (Homo sapiens) PubMed

 118.

This review focuses on the clustered nicotinic acetylcholine receptor genes CHRNalpha5/alpha3/beta4 and evaluates their role in nicotine addiction and lung cancer. (Homo sapiens) PubMed

 119.

CHRNA5-CHRNA3-CHRNB4 is involved in the transition toward heavy smoking in mid-adulthood and in smoking persistence. (Homo sapiens) PubMed

 120.

Variant A of the rs1051730 SNP of CHRNA5-A3-B4 gene cluster was significantly associated with smoking quantity in 2 Italian populations, Val Borbera and Cilento, no association was found in Carlantino population. (Homo sapiens) PubMed

 121.

Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 influences cognitive flexibility differently in African Americans compared to European Americans. (Homo sapiens) PubMed

 122.

none of the COMT SNPs were associated directly with nicotine dependence (ND); the interaction of intronic COMT SNP, rs9332377, with CHRNA3 3'UTR SNP rs660652 was significantly associated with ND (Homo sapiens) PubMed

 123.

Nicotinic acetylcholine receptor polymorphisms are associated with additional increased risk of lung cancer, bladder cancer, and chronic obstructive pulmonary disease after adjustment for smoking. (Homo sapiens) PubMed

 124.

Single Nucleotide Polymorphisms in CHRNA3 is associated with smoking persistence in African Americans. (Homo sapiens) PubMed

 125.

Sympathetic alpha3beta2-nAChRs mediate basilar artery neurogenic nitrergic vasodilation in swine. (Homo sapiens) PubMed

 126.

Polymorphisms in CHRNA3 gene is associated with lung squamous cell carcinoma. (Homo sapiens) PubMed

 127.

The A2A receptor reduces the desensitization of alpha3beta4 nAChR through the action of protein kinase A. Mutations disrupting the sequence 385RAES388 abolish PKA-induced changes in nAChR function. (Homo sapiens) PubMed

 128.

Variation in CHRNA5-A3-B4 was independently and additively associated with increased smoking, nicotine dependence, and lung cancer risk. (Homo sapiens) PubMed

 129.

No association was found for CHRNA3 SNPs in relation to adolescent smoking behavior. (Homo sapiens) PubMed

 130.

CHRNA3-CHRNA5 variation impacts indirectly on lung cancer risk (Homo sapiens) PubMed

 131.

CHRNA3 and CHRNA5 have roles in different forms of tobacco dependence, but the specific genetic variants do not account for much fo the total genetic variance for predisposition to nicotine dependence (Homo sapiens) PubMed

 132.

A weak effect of CHRNA3 rs1051730 genetic variation is observed on short-term smoking cessation. (Homo sapiens) PubMed

 133.

Data confirm the effect of variant within the promoter region of the CHRNA3 gene on nicotine dependence but failed to find any relationship with difficulty, willingness, and motivation to quit. (Homo sapiens) PubMed

 134.

Data show that luciferase expression was equivalent among CHRNA3 haplotypes, but the combination of deletion at rs3841324 and variation at rs503464 decreased CHRNA5 promoter-derived luciferase activity. (Homo sapiens) PubMed

 135.

Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) IS ASSOCIATED WITH SMOKING QUANTITY AND THE GENOTYPE MAY BE associated with BMI in smokers (Homo sapiens) PubMed

 136.

Single nucleotide polymorphism (SNP) CHRNA3 on chromosome 15 is not associated with Parkinson's disease risk in the overall anaylsis or after stratifying on smoking status. (Homo sapiens) PubMed

 137.

An interaction between tobacco smoke exposure and a CHRNA3/5 polymorphism was found for BHR in children, but CHRNA3/5 was not associated with asthma or lung function. (Homo sapiens) PubMed

 138.

Single nucleotide polymorphisms in CHRNA3 gene is associated with nicotine dependence. (Homo sapiens) PubMed

 139.

The data showed that IREB2 and CHRNA3 are potential genetic modifiers of chronic obstructive pulmonary disease in individuals with severe alpha-1 antitrypsin deficiency and may be sex-specific in their impact. (Homo sapiens) PubMed

 140.

This study demonstrates the additive and independent association of the nicotine metabolite ratio and SNPs in the CHRNA5/A3/B4 gene cluster with smoking rate in treatment-seeking smokers. (Homo sapiens) PubMed

 141.

This study examines whether the CHRNA5/CHRNA3/CHRNB4 locus is correlated also with externalizing behaviors in three independent longitudinally assessed adolescent samples (Homo sapiens) PubMed

 142.

Genetic variation within the CHRNA5-CHRNA3-CHRNB4 gene cluster is associated with nicotine dependence. (Homo sapiens) PubMed

 143.

CHRNA3 polymorphism on chromosome 15q25 is associated with early stage non-small-cell lung cancer. (Homo sapiens) PubMed

 144.

study provides evidence for a general role of the CHRNA5/A3/B4 gene cluster in substance use initiation that is not limited to nicotine and alcohol. (Homo sapiens) PubMed

 145.

vivo evidence of the involvement of the CHRNA5, CHRNA3 and CHRNB4 genomic cluster in nicotine addiction (Homo sapiens) PubMed

 146.

CHRNA3 gene rs1051730-A allele might be a risk-conferring factor for the development of lung cancer in Caucasians, but not in East-Asians. (Homo sapiens) PubMed

 147.

transgenic mice with human alpha 5, alpha 3, beta 4 subunit genes drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test; results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects (Homo sapiens) PubMed

 148.

Expression of alpha-3 neuronal nicotinic acetylcholine receptor subunit in sympathetic ganglia remains stable after brain death and determines the feasibility of sympathetic thoracic ganglia as a study group. (Homo sapiens) PubMed

 149.

The genetic risks of nicotine dependence associated with the CHRNA5-A3-B4 subunit genes are specific, and not shared among commonly comorbid psychiatric disorders (Homo sapiens) PubMed

 150.

Results suggest important role for CHRNA3 variants as genetic risk factor for airflow obstruction that may be independent of smoking status. (Homo sapiens) PubMed

 151.

A replication of association between two SNPs previously associated with COPD (CHRNA3/5 and IREB2), as well as an association with COPD of one locus initially associated with lung function (ADCY2). (Homo sapiens) PubMed

 152.

The involvement of alpha3/alpha5/beta4 nicotinic receptor subunit is determined in working memory and impulsivity, two behavioral traits that could promote development of nicotine dependence. (Homo sapiens) PubMed

 153.

Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in smokers and non-smokers. (Homo sapiens) PubMed

 154.

Thia case-control analysis revealed that an increased risk of lung cancer is associated with an SNP in CHRNA3, rs8040868. (Homo sapiens) PubMed

 155.

Data show a statistical association and suggest biological plausibility that the CHRNA3 rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer. (Homo sapiens) PubMed

 156.

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. (Homo sapiens) PubMed

 157.

The rs6495309 CT, or TT genotype of nicotinic acetylcholine receptor alpha subunit 3(CHRNA3) was associated with a significantly decreased risk of moderate to very severe chronic obstructive pulmonary disease. (Homo sapiens) PubMed

 158.

analysis of CHRNA3 genotype, nicotine dependence, lung function and disease in the general population (Homo sapiens) PubMed

 159.

The subjects carrying the minor "A" allele on rs1051730 in CHRNA3 may be at risk to develop COPD and/or lung cancer as well as nicotine-dependence. (Homo sapiens) PubMed

 160.

Genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the alpha5, alpha3, and beta4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence. (Homo sapiens) PubMed

 161.

we evaluate the utility of genetic variants in CHRNA3 for smoking as a risk factor in low birth weight (Homo sapiens) PubMed

 162.

SNP rs1051730 associated with smoking and body mass index (Homo sapiens) PubMed

 163.

silencing alpha3 nAChR mRNA might enhance the effect of Abeta25-35 on cell apoptosis by increasing the levels of p38 protein and bax mRNA and decreasing the level of bcl-2 mRNA, which may play a role in the pathogenesis of Alzheimer's disease (Homo sapiens) PubMed

 164.

Our findings uncover a novel mechanism of nicotine-induced alpha3beta4 nAChR upregulation that may be relevant also for other nAChR subtypes. (Homo sapiens) PubMed

 165.

Cell surface localization of alpha3beta4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. (Homo sapiens) PubMed

 166.

CHRNA3 polymorphism was associated with pack-year of smoking in chronic obstructive pulmonary disease Chinese Han patients (Homo sapiens) PubMed

 167.

CHRNA5-A3-B4 rs667282 TT/TG genotypes were associated with significantly increased risk of esophageal squamous cell carcinoma. (Homo sapiens) PubMed

 168.

Rare genetic variation in the CHRNA5-A3-B4 gene cluster contributes modestly to the level of response to alcohol. (Homo sapiens) PubMed

 169.

CHRNA3 gene rs3743073G variant genotype significantly increased lung cancer risk, especially in male smokers over the age of 60. (Homo sapiens) PubMed

 170.

Genetic variation in nicotinic receptor gene CHRNA3 might be an important connecting link between early attentional processes and smoking behavior. (Homo sapiens) PubMed

 171.

Genetic variations in CHRNA3 are associated with COPD in the Korean population. (Homo sapiens) PubMed

 172.

study identified an association between a nicotinic acetylcholine receptor a3 subunit variant (rs578776)and reward-related neural response in a large cohort of healthy non-smoking adolescents. (Homo sapiens) PubMed

 173.

Women with the variant AA genotype of CHRNA3 rs578775 were at significantly decreased risk of heavy smoking. (Homo sapiens) PubMed

 174.

Investigated associations between neuroticism and 13 SNPs in the CHRNA5 and CHRNA3 genes in young adult Mexican American men and women. (Homo sapiens) PubMed

 175.

Genetic variants in the CHRNA5-A3-B4 gene cluster alter nicotine intake and body mass index in a population of Alaska Native people, who have a distinct haplotype structure, smoking behaviors and prevalence of obesity. (Homo sapiens) PubMed

 176.

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence. (Homo sapiens) PubMed

 177.

rs1051730 polymorphism may modify susceptibility to lung cancer via a smoking-independent manner among Chinese Han population. (Homo sapiens) PubMed

 178.

Elucidation of the signaling events elicited upon agonist binding to corneal mAChRs and nAChRs will be crucial for understanding the mechanisms of ACh signaling in CECs, which has salient clinical implications. (Homo sapiens) PubMed

 179.

The minor alleles of two polymorphisms (rs578776 and rs3743078) in the CHRNA3 gene are associated with an increased risk of tobacco smoking only among patients with ADHD. (Homo sapiens) PubMed

 180.

CHRNA3 polymorphism functions as a genetic modifier of the risk of developing lung ADC in the Chinese population, particularly in nonsmoking females. (Homo sapiens) PubMed

 181.

Increased expression of NeuroD1 subsequently leads to regulation of expression and function of the nicotinic acetylcholine receptor subunit cluster of alpha3, alpha5, and beta4. (Homo sapiens) PubMed

 182.

Results show that CHRNA3 genotype is associated with decreased lung function and risk of chronic obstructive pulmonary disease. among ever-smokers, whereas this was not the case for CYP3A5*3. (Homo sapiens) PubMed

 183.

High cumulative tobacco consumption is associated with short telomeres observationally, but there is no clear genetic association. (Homo sapiens) PubMed

 184.

The alpha3beta4* nicotinic ACh receptor subtype mediates physical dependence to morphine (Homo sapiens) PubMed

 185.

In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression, anxiety or psychological distress in current or former smokers. [Meta-analysis] (Homo sapiens) PubMed

 186.

Suggest no relationship between these smoking-related SNPs in the CHRNA5/A3/B4 gene cluster and psoriasis vulgaris in Chinese Han population. (Homo sapiens) PubMed

 187.

GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use. (Homo sapiens) PubMed

 188.

The frequencies of genotype and allele in CHRNA3 (rs8040868) and PHACTR2 (rs9390123) were not significantly different between the NSCLC cases and controls, or between either of the subgroups. (Homo sapiens) PubMed

 189.

the haplotype analysis found that the haplotypes "TCAC" and "CTGT," composed of rs938682, rs12914385, rs11637630, and rs2869546, were associated with a 1.79-fold and 501-fold increased lung cancer risk (Homo sapiens) PubMed

 190.

Study provides new evidence that the overexpression of the CHRNA5/A3/B4 region disrupts pyramidal neuronal structure in the hippocampus, and thus affecting the cognitive capacities (Homo sapiens) PubMed

 191.

Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese. (Homo sapiens) PubMed

 192.

Of the 2305 SNPs identified in the CHRNA3 gene, 115 were found to be non-synonymous and 12 and 15 nsSNPs were found to be in the 5' and 3' UTRs, respectively. 115 nsSNPs investigated, eight were predicted to be deleterious by both SIFT and PredictSNP servers. (Homo sapiens) PubMed

 193.

CHRNA5-A3-B4 genotype associates with body mass index in never smokers. (Homo sapiens) PubMed

 194.

Four SNPs in the CHRNA3/5 locus are associated with chronic obstructive pulmonary disease risk. [Meta-analysis] (Homo sapiens) PubMed

 195.

The positive interaction between heavy smoking and the homozygous mutant CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers. (Homo sapiens) PubMed

 196.

Data suggest that CHRNA5-A3-B4 gene variants do not exhibit a robust association with smoking cessation and are unlikely to be useful for clinically optimizing smoking cessation pharmacotherapy for Caucasian smokers. (Homo sapiens) PubMed

 197.

CHRNA3 - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies. (Homo sapiens) PubMed

 198.

two SNPs (rs6495308 and rs11072768) in CHRNA5-A3-B4 have a indirect effect on lung cancer through smoking behaviors (Homo sapiens) PubMed

 199.

Our data suggest that gene variance in the CHRNA5-CHRNA3-CHRNB4 cluster is associated with an increased risk of death, incidence of COPD and tobacco-related cancer in smokers. (Homo sapiens) PubMed

 200.

At CHRNA3, allele G of rs3743078 was associated with increased nicotine craving. (Homo sapiens) PubMed

 201.

focus on the CHRNA5/A3/B4 gene cluster and its role in nicotine dependence (review) (Homo sapiens) PubMed

 202.

CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers. (Homo sapiens) PubMed

 203.

the association of 3 selected single-nucleotide polymorphisms (CHRNA3 rs1051730, rs6495308, and CHRNA5 rs55853898) with nicotine dependence in an isolated population of Kashubians from Poland, is reported. (Homo sapiens) PubMed

 204.

both rs578776 and rs938682 of CHRNA3 were significantly associated with the susceptibility of lung cancer. (Homo sapiens) PubMed

 205.

The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance. (Homo sapiens) PubMed

 206.

The minor allele increased the risk of COPD when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD patients and with the number of pack-years among the male smokers. (Homo sapiens) PubMed

 207.

CHRNA3 genetic risk score was associated with successful smoking cessation in a Chinese rural population. (Homo sapiens) PubMed

 208.

our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control. (Homo sapiens) PubMed

 209.

The rs13180 (IREB2), rs16969968 (CHRNA5) and rs1051730 (CHRNA3) were significantly associated with Chronic obstructive pulmonary disease (COPD) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD in our population (Padj =0.0005, OR=0.61). (Homo sapiens) PubMed

 210.

Data indicate potential associations between CHRNA3polymorphisms and schizophrenia susceptibility, and the significant variants identified in our study may be used as genetic biomarkers for schizophrenia susceptibility in Chinese Han population (Homo sapiens) PubMed

 211.

Frequency of the cholinergic receptor nicotinic alpha 5 (CHRNA5) rs16969968-A allele and cholinergic receptor nicotinic alpha 3 (CHRNA3) rs1051730-T allele were significantly higher in lung cancer than in normal controls. (Homo sapiens) PubMed

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