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GeneWiki for A2m:
GeneNetwork:
1.
Apparently genuine segmental duplication of A2M in the rat.
GeneRIF from NCBI:
1.
Alpha2 macroglobulin requires cyclic amp and signal transduction for cell growth (Mus musculus) PubMed
2.
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin. (Mus musculus) PubMed
3.
the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents (Mus musculus) PubMed
4.
Data describe the role of the PI3-kinase/PDK/Akt/p70s6k signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB in these events. (Mus musculus) PubMed
5.
review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy. (Mus musculus) PubMed
6.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind (Mus musculus) PubMed
7.
PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit (Mus musculus) PubMed
8.
IL-11 signals through the Jak2/Stat3 pathway in decidual cells to stimulate the expression of alpha(2)-MG, a protease inhibitor essential for normal placentation in pregnancy. (Mus musculus) PubMed
9.
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin (Mus musculus) PubMed
10.
Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum. (Mus musculus) PubMed
11.
These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system. (Mus musculus) PubMed
12.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5 (Mus musculus) PubMed
13.
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles. (Mus musculus) PubMed
14.
MMP9 production promoted by the alpha(2)M*/LRP1 interaction required the activation of both MAPK-ERK1/2 and NF-kappaB signaling pathways. (Mus musculus) PubMed
15.
Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase. (Mus musculus) PubMed
16.
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis. (Mus musculus) PubMed
17.
We report here for the first time the direct isolation of Spp24 covalently bound to alpha2-macroglobulins as a core complex (Spp24-alpha2M) from bovine calf serum. (Mus musculus) PubMed
18.
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. (Mus musculus) PubMed
19.
Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows. (Mus musculus) PubMed
20.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M), murinoglobulin double-knockout (DKO), and wild-type mice (Mus musculus) PubMed
21.
role in reducing calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in hippocampal neurons (Rattus norvegicus) PubMed
22.
Alpha 2 macroglobulin is directly responsible for causation of anemia in the hosts of Yoshida ascites sarcoma by affecting erythrocyte deformability. (Rattus norvegicus) PubMed
23.
DNA binding activity on the rat alpha2-macroglobulin gene promoter is regulated in an acute-phase dependent manner (Rattus norvegicus) PubMed
24.
cardiac hypertrophy may be induced by the presence of alpha-2 Macroglobulin, cardiac isoform (Rattus norvegicus) PubMed
25.
phosphorylation of LRP by PKCalpha modulates the endocytic and signaling function of LRP by modifying its association with adaptor proteins (Rattus norvegicus) PubMed
26.
alpha 2 macroglobulin has a role in development of rat hepatocellular preneoplastic and neoplastic lesions (Rattus norvegicus) PubMed
27.
bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin (Rattus norvegicus) PubMed
28.
Data suggest that alpha(2)macroglobulin gene expression is driven by developmental- and acute-phase-related mechanisms that rely on STAT3/NF-kappaB interplay. (Rattus norvegicus) PubMed
29.
involvement of STAT5b in alpha(2)-macroglobulin gene expression during development (Rattus norvegicus) PubMed
30.
Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma (Rattus norvegicus) PubMed
31.
Role of cardiac isoform of alpha-2 macroglobulin in diabetic myocardium. (Rattus norvegicus) PubMed
32.
alpha2-macroglobulin is neurotoxic by inhibiting neuroprotective activity of nerve growth factor via TrkA receptors. (Rattus norvegicus) PubMed
Peak serum levels of alpha(2)-macroglobulin and alpha(1)-acid glycoprotein injected at 0.05 mL/rat were significantly lower than those at 0.2 or 0.4 mL/rat. No significant differences were observed for peak serum levels at 0.2 and 0.4 mL/rat. (Rattus norvegicus) PubMed
35.
Differentiation of protein species of alpha-2u-globulin according to database entries (Rattus norvegicus) PubMed
36.
elevated serum level correlated to glucocorticoid treatment and may represent a form of reparative response to glucocorticoid-associated damage of bone (Rattus norvegicus) PubMed
37.
Gastric contents-induced acute lung injury elicits a liver acute phase response characterized by increased mRNA expression of alpha 2 macroglobulin and alpha1-antitrypsin. (Rattus norvegicus) PubMed
38.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
39.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
40.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
41.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
42.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
43.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
44.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
45.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
46.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
47.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
48.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
49.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
50.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
51.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
52.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
53.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
54.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
55.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
56.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
57.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
58.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
59.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
60.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
61.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
62.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
63.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
64.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
65.
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
66.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
67.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
68.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
69.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
70.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
71.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
72.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
73.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
74.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
75.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
76.
Differential binding to ldl receptor related protein (Homo sapiens) PubMed
77.
distinct binding sites mediate interaction with beta-amyloid peptide and growth factors (Homo sapiens) PubMed
78.
has an important role in the AD-specific neurodegenerative process but its exon 24 Val-1000-Ile polymorphism is not likely to be associated with late-onset sporadic AD in the Hungarian population (Homo sapiens) PubMed
79.
REVIEW: binds and neutralizes alfimeprase, which has direct proteolytic activity against the fibrinogen Aalpha chain (Homo sapiens) PubMed
80.
The three-dimensional structure of the dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes. (Homo sapiens) PubMed
81.
relationship between serum VEGF levels, alpha(2)M levels and the development of OHSS in hyperstimulated subjects undergoing IVF (Homo sapiens) PubMed
82.
Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma. (Homo sapiens) PubMed
83.
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin. (Homo sapiens) PubMed
84.
Genetic association of alpha2-macroglobulin polymorphisms with Alzheimer's disease (Homo sapiens) PubMed
85.
These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system. (Homo sapiens) PubMed
86.
alpha(2)M-derived peptides target the receptor-binding sequence in TGF-beta (Homo sapiens) PubMed
87.
FGF-2 and this protein interact at specific binding sites, involving different FGF-2 sequences. (Homo sapiens) PubMed
88.
There is a significant genetic association of the 5 bp deletion and two novel polymorphisms in alpha-2-macroglobulin alpha-2-macroglobulin precursor with AD (Homo sapiens) PubMed
89.
alpha2-macroglobulin inhibits human pepsin and gastricsin (Homo sapiens) PubMed
90.
alpha2-M deletion polymorphism is probably not associated with functional deficiencies important in Alzheimer's disease pathology (Homo sapiens) PubMed
91.
A2M-D allele played a weak Alzheimer disease protective role, and APOE-E4 and A2M-G alleles might act synergistically in Alzheimer disease risk for mainland Han Chinese. (Homo sapiens) PubMed
92.
Plasma from patients homozygous for the intronic deletion (DD) showed normal alpha(2)M subunit size, conformation, and proteinase inhibitory activity. Plasma alpha(2)M from two DD patients showed markedly increased TGF-beta1 binding. (Homo sapiens) PubMed
93.
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5 (Homo sapiens) PubMed
94.
The presence of MPO-G/G and A2M-Val/Val genotypes synergistically increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75). (Homo sapiens) PubMed
95.
an important involvement of alpha2M in regulation of increased proteolytic activity occurring in multiple sclerosis disease (Homo sapiens) PubMed
96.
increased alpha(2)-macroglobulin expression appears to be associated with benign prostatic hyperplasia (Homo sapiens) PubMed
97.
Results of this study revealed no association between the I1000V polymorphism of A2M and Chinese sporadic AD in Guangzhou and Chengdu. (Homo sapiens) PubMed
98.
PAK-2 is activated in 1-LN prostate cancer cells by a proteinase inhibitor, alpha 2-macroglobulin (Homo sapiens) PubMed
99.
These studies demonstrate that a single mutation in full-length r(alpha)2M is sufficient to block binding to LRP-1. (Homo sapiens) PubMed
100.
A2M gene was suggested to be associated with Alzheimer's disease. (Homo sapiens) PubMed
101.
results indicate that secondary proteolysis of alpha2-macroglobulin promotes impaired control of extracellular proteolytic activity, leading to local and distant tissue injuries during severe acute pancreatitis (Homo sapiens) PubMed
102.
review of the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy (Homo sapiens) PubMed
103.
the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind (Homo sapiens) PubMed
104.
PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit (Homo sapiens) PubMed
105.
In this proteins two amino acid polymorphisms (Ile/Val A-->G) have been associated with an increased risk for Alzheimer's disease (AD) and the combination with CTSD-T allele seems to increase this risk. (Homo sapiens) PubMed
106.
results did not support the hypothesis that A2M deletion polymorphism is associated with a low A2M concentration in overweight/obese subjects (Homo sapiens) PubMed
107.
bone morphogenetic protein 1 is inhibited by native and altered forms of alpha2-macroglobulin (Homo sapiens) PubMed
108.
alpha(2)M* binding to LRP-1 induces cell proliferation and MAPK activation in the J774 macrophage-derived cell line (Homo sapiens) PubMed
109.
The risk of symptomatic thromboembolism was significantly increased with elevated alpha2MG levels. (Homo sapiens) PubMed
110.
alpha2-macroglobulin may facilitate conformational changes in prion protein in spontaneous forms of prion disease (Homo sapiens) PubMed
111.
expression and characterization of three alpha(2)M domains predicted to be involved in the stabilization of the thiol ester in native alpha2M and in its activation upon bait region proteolysis. (Homo sapiens) PubMed
112.
Alpha 2M activated by neutrophil elastase to its receptor-recognized form binds CpG ODN and enhances their immunostimulatory properties significantly. (Homo sapiens) PubMed
113.
Decreased expression of alpha2-M mRNA and protein and protease inhibitory activity in the vaginal wall tissues of women with stress urinary incontinence(SUI) may contribute to the development of SUI. (Homo sapiens) PubMed
114.
alpha2M is a newly discovered and unique member of a small group of abundant extracellular proteins with chaperone properties (Homo sapiens) PubMed
115.
A2M allele and genotype frequencies were similar between AD patients and controls. (Homo sapiens) PubMed
116.
Senile systemic amyloidosis was associated with age, myocardial infarctions, the G/G (Val/Val) genotype of the exon 24 polymorphism in the alpha2-macroglobulin (alpha2M), and the H2 haplotype of the tau gene (Homo sapiens) PubMed
117.
effects of intact alpha(2)M on cell physiology reflect the degree of penetration of activities associated with different domains (Homo sapiens) PubMed
118.
Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism. (Homo sapiens) PubMed
119.
both alpha(2)M and Hp are likely to play an important role in controlling the inappropriate aggregation of proteins in the extracellular environment. (Homo sapiens) PubMed
120.
An ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3 in Alzheimer disease. (Homo sapiens) PubMed
121.
LRP1 bound A2M* found to be associated with an inhibition of tumor cell proliferation, migration, invasion, spheroid formation, and anchorage-independent growth. (Homo sapiens) PubMed
122.
These data support an involvement of the suggested A2M risk haplotype in the pathogenesis of Alzheimer's disease and adds new evidence to the risk-allele depletion hypothesis. (Homo sapiens) PubMed
123.
SP-D utilizes a novel mechanism in which the collectin interacts with protease inhibitor A2M to decrease its degradation and to concurrently increase its innate immune function. (Homo sapiens) PubMed
124.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
125.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
126.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
127.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
128.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
129.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) (Homo sapiens) PubMed
130.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) (Homo sapiens) PubMed
131.
Galectin-3 Binding Protein and Alpha-2 macroglobulin were differentially expressed on DVT patients in microparticles extracted from platelet-poor plasma (Homo sapiens) PubMed
132.
Haplotype -88G/25G might play a protective role in the development of SAD, and the protective effects of -88G and 25G were independent of APOEvarepsilon4 allele. (Homo sapiens) PubMed
133.
Reduced expression of alpha-2 macroglobulin and complement factor B was detected in sera of patients with nasopharyngeal carcinoma. (Homo sapiens) PubMed
134.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
135.
LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. (Homo sapiens) PubMed
136.
statistically significant evidence of interaction between the polymorphisms in A2M, SLC6A4 and UCHL1 genes (global P = 0.0107, for the best model) and the risk for PD. (Homo sapiens) PubMed
137.
The extracellular chaperone alpha-2-macroglobulin is likely to help control amyloid formation and toxicity in vivo (Homo sapiens) PubMed
138.
Alpha-2-macroglobulin is an extracellular chaperone (Homo sapiens) PubMed
139.
The chaperone action of alpha-2-macroglobulin targets prefibrillar species to inhibit amyloid formation (Homo sapiens) PubMed
140.
The chaperone action of alpha-2-macroglobulin inhibits the toxicity and uptake of A beta in human cerebrospinal fluid (Homo sapiens) PubMed
141.
dimeric alpha2M as well as tetrameric alpha2M may play an important role in controlling beta2-m amyloid fibril formation (Homo sapiens) PubMed
142.
alpha2-macroglobulin is neurotoxic by inhibiting neuroprotective activity of nerve growth factor via TrkA receptors. (Homo sapiens) PubMed
143.
Identify a novel transcriptional regulatory element contributing to the up-regulation of alpha2M during replicative senescence. (Homo sapiens) PubMed
144.
We observed that the most informative biomarkers for predicting significant liver fibrosis in chronic hepatitis C patients were blood levels of alpha2-macroglobulin and hyaluronic acid (Homo sapiens) PubMed
145.
Ethnicity affects the genetic association of A2M with rheumatoid arthritis in South Asian and Caucasian patients living in East Midlands/United Kingdom. (Homo sapiens) PubMed
146.
alpha-2-macroglobulin (a2M) deficiency develops from catabolism of a2M in androgen-dependent advanced prostate cancer patients (Homo sapiens) PubMed
147.
investigation of secondary structure and thermal stability of recombinant bodhesin 2, a spermadhesin from seminal plasma (Homo sapiens) PubMed
148.
an isoform of ASP cleaved proteins more in plasma and was inhibited by human alpha(2)-macroglobulin more slowly than single-chain ASP (Homo sapiens) PubMed
149.
Complexes between alpha2-macroglobulin and urokinase were detected in alveolar edema fluids as well as in lungs of patients with acute lung injury/acute respiratory distress syndrome where they were located mainly in close proximity to epithelial cells. (Homo sapiens) PubMed
150.
inhibitory activity of Aeromonas sobria serine protease by alpha2-macroglobulin (Homo sapiens) PubMed
151.
protease-activated alpha2M has two mechanisms for inhibiting amyloid formation: via protease-alpha2M-mediated degradation of amyloidogenic substrates and by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway. (Homo sapiens) PubMed
152.
[review] alpha2M has many diversified and complex functions but is primarily known by its ability to inhibit a broad spectrum of proteases without the direct blockage of the protease active site. (Homo sapiens) PubMed
153.
IGFBP-2 associates with alpha2-macroglobulin in the blood circulation. (Homo sapiens) PubMed
154.
Oxidative stress and the levels of endogenous plasma prolyl oligopeptidase (PREP) inhibitor alpha-2-macroglobulin (alpha2M) decrease PREP activity in patients with multiple sclerosis. (Homo sapiens) PubMed
155.
While activated alpha-2-microglobulin (AA2M) ligates only one GRP78 receptor molecule per AA2M, it may potentially serve as a reservoir for release of up to four binding fragments per molecule. (Homo sapiens) PubMed
156.
Serum monomeric alpha2-macroglobulin is highly expressed in many diabetic subjects. (Homo sapiens) PubMed
157.
alpha2macroglobulin stimulates endothelial and early cardiac muscle differentiation of embryonic stem cells through generation of induction of FGF-2 expression. (Homo sapiens) PubMed
158.
A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. (Homo sapiens) PubMed
159.
Eosinophil activation occurred in early and late responses after L-ASA NPT in upper airway mucosa of AERD patients, where ApoA1, alpha2M and CP as well as CysLT may be involved in eosinophilic inflammation. (Homo sapiens) PubMed
160.
There is no statistically significant difference in allele or genotype frequencies between patients with sporadic Alzheimer's disease and control subjects for the A2M polymorphism. (Homo sapiens) PubMed
161.
FEIgG and alpha2m/C are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide; their predictive value, if validated in prospective studies, may be useful in clinical practice (Homo sapiens) PubMed
162.
alpha2M is a specialized chaperone that prevents the extracellular accumulation of misfolded and potentially pathogenic proteins, particularly during innate immune system activity (Homo sapiens) PubMed
163.
genetic variation within the A2M gene influences CSF Ab42 levels. (Homo sapiens) PubMed
164.
phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein. (Homo sapiens) PubMed
165.
there is no enough evidence for associations of A2M gene polymorphisms (5 bp I/D, Ile1000Val) with Alzheimer's disease risk (Homo sapiens) PubMed
166.
Alpha2M causes neurodegeneration in a p75(NTR)- and proNGF-dependent manner. (Homo sapiens) PubMed
167.
A2M is not the only biological candidate gene for AD determination (Homo sapiens) PubMed
168.
Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland. (Homo sapiens) PubMed
169.
A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2/9 activity by several mechanisms including the up-regulation of A2M. (Homo sapiens) PubMed
170.
we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins (Homo sapiens) PubMed
171.
These data demonstrate that alpha2M* and LRP1 modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2+)dynamics in hMSMCs during pregnancy. (Homo sapiens) PubMed
172.
Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease. (Homo sapiens) PubMed
173.
This work demonstrates that alpha2M*/CS-GRP78 acts as an upstream regulator of the PDK1/PLK1 signaling axis to modulate c-MYC transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC-associated malignant progression. (Homo sapiens) PubMed
174.
Data show that low that low globulin (GLB) levels were significantly associated with favorable survival, and low ALB levels were associated with a significantly worse survival . (Homo sapiens) PubMed
175.
Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control. (Homo sapiens) PubMed
176.
The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ... (Homo sapiens) PubMed
177.
Case Reports: inflammatory myofibroblastic tumors of the lung containing a chimeric A2M-ALK gene categorized as a specific type of inflammatory myofibroblastic tumor that develops exclusively in neonates and infants. (Homo sapiens) PubMed
178.
BBB disruption is present in ACS, and elevated levels of IL-6 and C3 in CSF in diffuse NPSLE (Homo sapiens) PubMed
179.
Proteomics study showed a strong association of FN1, A2M, C4BPA and CFB in molecular subtypes of breast cancer, in which, C4BPA and A2M demonstrated a potent signature in blood plasma and tissue samples of Luminal-B (LB) and Triple-negative (TN)subtypes in BC patients, respectively. (Homo sapiens) PubMed
180.
The blood coagulation pathway may be a key regulatory network pathway contributing to the allergic inflammatory response in AR patients. A2M, which is regulated by STAT3, may be an important protein in the pathogenesis of allergic rhinitis in AR patients. (Homo sapiens) PubMed
181.
Serum alpha2MG levels might reflect endothelial dysfunction evaluated by flow-mediated dilation in patients with chronic stroke or cardiovascular risk factors (Homo sapiens) PubMed
182.
the binding of IGFBP-2 to alpha2M seems to be related to structural changes in the glycan moieties of alpha2M, whereas binding of Zn ions, most likely, is not. (Homo sapiens) PubMed
183.
In advanced prostate cancer with PSA levels >1000 ng/mL, sufficient PSA-A2M is present in circulation to produce enzymatic activity against circulating small peptide hormones. (Homo sapiens) PubMed
184.
Impaired fibrinolysis and lower levels of alpha2-macroglobulin might predispose to a higher rate of asthma exacerbations, suggesting new links between disturbed hemostasis and asthma. (Homo sapiens) PubMed
185.
High A2M expression is associated with Pancreatic cancer. (Homo sapiens) PubMed
186.
Significantly lower levels of alpha-2-macroglobulin were found in the serum of patients with steroid-induced necrosis of the femoral head (SINFH) than in controls (P < 0.05). Immunohistochemical staining and western blotting demonstrated that the expression of alpha-2-macroglobulin was significantly decreased in the necrotic area of SINFH patients (P < 0.05). (Homo sapiens) PubMed
187.
The results suggest that A2M positively regulates Microvesicle shedding through the activation of LRP1 on myofibroblasts. (Homo sapiens) PubMed
188.
Molecular form and concentration of serum alpha2-macroglobulin in diabetes. (Homo sapiens) PubMed
Web services initiated January, 1994 as Portable Dictionary of the Mouse Genome; June 15, 2001 as WebQTL; and Jan 5, 2005 as GeneNetwork.
This site is currently operated by
Rob Williams,
Pjotr Prins,
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Arthur Centeno. Design and code by Pjotr Prins, Zach Sloan, Arthur Centeno, Danny Arends, Christian Fischer, Sam Ockman, Lei Yan, Xiaodong Zhou, Christian Fernandez, Ning Liu, Rudi Alberts, Elissa Chesler, Sujoy Roy, Evan G. Williams, Alexander G. Williams, Kenneth Manly, Jintao Wang, and Robert W. Williams, colleagues.
