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GeneWiki for Shh:
GeneNetwork:
1.
Expression signature for cells in globus pallidus and cerebellar Purkinje cells of adults (ABA).
2.
Associated with glioma.
3.
Possible retinal ganglion cell marker.
GeneRIF from NCBI:
1.
protein localized to the posterior margin of vertebrate limb buds; key signal in establishing anterior-posterior limb polarity (Mus musculus) PubMed
2.
member of the Hedgehog family of signaling molecules involved in embryonic patterning and morphogenesis; present in target compartments but detection requires proteoglycan/glycosaminoglycan preservation (Mus musculus) PubMed
3.
Fgf4 can ectopically induce SHH expression in the anterior margin of hindlimb bud, but not of forelimb bud (Mus musculus) PubMed
4.
Shh is transcriptionally regulated by RORa in cerebellar Purkinje cells. (Mus musculus) PubMed
5.
expression stimulated by adenovirus-mediated increase in HNF-3 levels (Mus musculus) PubMed
6.
Shh signaling controlS Myf5, a skeletal muscle regulatory gene for specification of muscle stem cells in vertebrate embryos. (Mus musculus) PubMed
7.
Sonic hedgehog interactions with heparan sulfate proteoglycans promote maximal proliferation of postnatal day 6 granule cells (Mus musculus) PubMed
8.
Sonic hedgehog is both necessary and sufficient to inhibit dorsolateral bending, but is neither necessary nor sufficient to induce midline bending, which seems likely to be regulated by another notochordal factor. (Mus musculus) PubMed
tested the hypothesis that localized transient overexpression of PTCH would inhibit the phenotype of SHH-induced accelerated growth of hair follicles (Mus musculus) PubMed
13.
activates Bmp2 expression in the palatal mesenchyme which in turn acts as a mitogen to stimulate cell division (Mus musculus) PubMed
14.
Endogenously produced Shh may play a role in sustaining normal CD4(+) T cell proliferation and exogenously added Shh enhances this response. (Mus musculus) PubMed
15.
localization of Sonic hedgehog (Shh) protein and expression of the Shh gene in the tissues of the developing mouse inner ear (Mus musculus) PubMed
16.
genetic analyses in mice showing that Shh and Gli3 are dispensable for formation of limb skeletal elements: Shh(-/-) Gli3(-/-) limbs are distally complete and polydactylous, but completely lack wild-type digit identities (Mus musculus) PubMed
17.
genetic analysis indicates that SHH signaling counteracts GLI3-mediated repression of key regulator genes, cell survival, and distal progression of limb bud development (Mus musculus) PubMed
18.
neither Shh nor Ihh is required for mammary gland morphogenesis and functional differentiation (Mus musculus) PubMed
19.
When Ad-cShh was expressed in the epidermis, Bmp4, Ptch, Ptch2 and Gli1 were induced ectopically in the interfollicular region. In contrast, the expression of Bmp2 and Shh itself was unaltered. (Mus musculus) PubMed
identifies Sonic hedgehog (Shh) secreted by the notochord and/or floor plate as a primary regulator of auditory cell fates within the mouse inner ear (Mus musculus) PubMed
22.
in mammals, Gli1 is not required for Shh signaling and that Gli2 mediates inappropriate activation of the pathway due to loss of the negative regulator Ptc. (Mus musculus) PubMed
23.
Shh-dependent signaling relay regulates proliferation and survival of dorsal cell populations in the diencephalon and midbrain. We present evidence that Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction (Mus musculus) PubMed
24.
Shh signaling is required within the notochord to maintain Shh expression and to prevent notochord degeneration. Disp1, unlike Smo, is not required for this juxtacrine signaling by Shh. (Mus musculus) PubMed
25.
Hedgehog body patterning is influenced by dispatched gene product (Mus musculus) PubMed
26.
Shh is involved in osteoblast differentiation by cooperating with BMP2. (Mus musculus) PubMed
27.
normal patterning in the telencephalon depends on the ventral repression of Gli3 function by Shh and, conversely, on the dorsal repression of Shh signaling by Gli3 (Mus musculus) PubMed
28.
sonic hedgehog promotes mesenchymal cell proliferation, regulates the timing of differentiation of smooth muscle progenitor cells, and sets the pattern of mesenchymal differentiation through its dose-dependent inhibition of smooth muscle formation (Mus musculus) PubMed
29.
Data show that sonic hedgehog (Shh)-dependent interactions occur within the dental epithelium itself. (Mus musculus) PubMed
30.
Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities. (Mus musculus) PubMed
31.
these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors (Mus musculus) PubMed
32.
Homozygous Msx1/Hx double mutants exhibit a postaxial polydactyly at birth, demonstrating that the two genes interact. (Mus musculus) PubMed
33.
Shh promotes GABAergic neuronal oligodendrocyte lineage restriction of forebrain stem cells, in part, by activation of the basic helix-loop-helix transcription factors, Olig2 and Mash1. (Mus musculus) PubMed
34.
induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase (Mus musculus) PubMed
35.
The Tbx1 regulatory region was responsive to signaling by Sonic hedgehog (Shh) in vivo. (Mus musculus) PubMed
36.
Sonic hedgehog-dependent Gli2 activation plays a critical role in epithelial homeostasis by promoting proliferation through the transcriptional control of cell cycle regulators. (Mus musculus) PubMed
37.
FGF10 is required for proper whisker development mediated by SHH signaling in the mouse (Mus musculus) PubMed
38.
Shh negatively regulates prostatic ductal branching indirectly by acting on the surrounding stromal cells, at least partly via up-regulating expression of activin A and TGF-beta1 (Mus musculus) PubMed
39.
Role for hedgehog signaling in regeneration and carcinogenesis of airway epithelium (Mus musculus) PubMed
40.
during the hair cycle, Shh expression and the ability of skin cells to respond to Shh signaling is spatially and temporally regulated (Mus musculus) PubMed
41.
plays two key roles during taste bud development: as a morphogen that directs cells toward a nonpapillary fate, and as a mitogen, causing expansion of the interplacodal epithelium and underlying mesenchyme (Mus musculus) PubMed
42.
The RT-PCR showed that Shh mRNA was detected at the tibia fracture site from day 2 postfracture, but not from days 0 and 12. (Mus musculus) PubMed
43.
Sonic hedgehog (Shh) can mimic the additional chemoattractant activity of the floor plate in vitro and can act directly as a chemoattractant on isolated axons. (Mus musculus) PubMed
44.
Data show that sonic hedgehog from retinal ganglion cells promotes the development of optic disc and stalk neuroepithelial cells. (Mus musculus) PubMed
45.
Hedgehog target gene transcripts were only modestly upregulated in follicular hamartomas, in contrast to the high levels detected in basal cell carcinomas (Mus musculus) PubMed
46.
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. (Mus musculus) PubMed
47.
Exogenous recombinant Shh protein sustains the survival and proliferation of lung mesenchyme in a dose-dependent manner. (Mus musculus) PubMed
48.
Results identify a sonic hedgehog (Shh)-responsive regulatory element that directs transgene reporter expression and characterize critical cis-acting sequences regulating this element. (Mus musculus) PubMed
49.
Wnt 7a, Wnt 7b, and Sonic hedgehog (Shh) promote progenitor cell maturation in explant cultures, as reported for FGF2. Wnts 7a and 7b also stimulate proliferation of neurogenic progenitors (Mus musculus) PubMed
50.
Skeletal muscle ischemia induces strong local upregulation of Shh mRNA and protein. The Ptc1 receptor is activated in interstitial mesenchymal cells within the ischemic area, indicating these cells respond to Shh and that the Shh pathway is functional (Mus musculus) PubMed
51.
Patched (Ptc)induces apoptotic cell death unless its ligand Shh is present to block the signal; the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve spinal cord development (Mus musculus) PubMed
52.
model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors (Mus musculus) PubMed
53.
Sonic hedgehog is regulated by IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain (Mus musculus) PubMed
54.
Sonic hedgehog signaling is required to maintain progenitor cells in the postnatal telencephalon. (Mus musculus) PubMed
55.
Pancreas of Pdx-Shh mice (in which Shh is misexpressed in the pancreatic endoderm) develop abnormal tubular structures; maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis (Mus musculus) PubMed
56.
BMP-2 and Shh can induce alkaline phosphatase reliance on Wnt expression and the Wnt/LRP5 signaling cascade (Mus musculus) PubMed
57.
Exogenous Bmp4 reduced interneuron production by embryonic telencephalon stem cell explants and inhibited induction by exogenous Shh; inhibiting BMP signaling with dominant-negative BMP receptor Ib increased interneuron number even with Shh blocked (Mus musculus) PubMed
58.
Sonic Hedgehog(shh) under the control of HK1 promoter results in the inhibition of embryonic hair follicle morphogenesis. (Mus musculus) PubMed
59.
data suggest that polydactyly in the raz mutant is due to an increased and uniform concentration of the Gli3 repressor form because of lowered sonic hedgehog signaling (Mus musculus) PubMed
60.
Shh signaling is essential for sclerotome development in the mouse. (Mus musculus) PubMed
61.
identification of two mouse mutants, wimple (wim) and flexo (fxo), that lack ventral neural cell types and show other phenotypes characteristic of defects in Sonic hedgehog signalling (Mus musculus) PubMed
62.
Data show that both sonic hedgehog and indian hedgehog are expressed in the developing embryonic mouse mammary rudiment as early as embryonic day 12.5. (Mus musculus) PubMed
63.
Hedgehog pathway activation led to striking increase both in size and number of sebaceous glands. Ectopic Hedgehog signaling triggered the formation of sebaceous glands from footpad epidermis, in regions normally devoid of hair follicles. (Mus musculus) PubMed
64.
Olig2 expression at early stages of development identifies a domain in the developing spinal cord which contains a heterogeneous population of progenitor cells. Olig2 knockout leads to a loss of oligodendrocytes with preservation of NG2 expression. (Mus musculus) PubMed
65.
SHH signaling is important for prostatic growth, branching, and proliferation. (Mus musculus) PubMed
66.
Shh and PI3K signaling pathways converge on N-Myc to regulate neuronal precursor cell cycle progression. (Mus musculus) PubMed
67.
Neurospheres generated from SHH null mice produce oligodendrocytes, even in the presence of cyclopamine. (Mus musculus) PubMed
68.
SHH signaling endogenously regulates the number of embryonic and postnatal mouse neocortical cells with stem cell properties (Mus musculus) PubMed
69.
Shh is necessary for expansion of CD4-CD8- double-negative (DN) thymocytes and for efficient transition from the earliest CD44+CD25- DN population to the subsequent CD44+CD25+ DN population and from DN to CD4+CD8+ double-positive cells. (Mus musculus) PubMed
70.
expressed in notochord, floor plate and prechordal mesoderm, no ectopic expression in polydactyly/arhinencephaly mouse (Mus musculus) PubMed
71.
activin A does not appear to affect the exocrine or endocrine components of the pancreas, but promotes differentiation of pancreatic tissue into intestine via a Shh-dependent mechanism (Mus musculus) PubMed
72.
The Shh deficient mutant mouse demonstrates complete agenesis of genital tubercle outgrowth. (Mus musculus) PubMed
73.
Redundant 5'Hoxd genes regulate digit pattern downstream of Shh and Gli3. (Mus musculus) PubMed
74.
Results show that FKBP8 is an essential antagonist of sonic hedgehog signaling in central nervous system development. (Mus musculus) PubMed
75.
Shh signalling is required for the correct development/maturation of the dorsal root ganglia (Mus musculus) PubMed
76.
Shh signaling indirectly governs the symmetric bilobation of the thyroid during late organogenesis (Mus musculus) PubMed
77.
Results describe the role of Sonic hedgehog signaling on Gli3 processing in lung growth and differentiation by regulating several critical genes. (Mus musculus) PubMed
78.
Control of the position of tooth initiation in the mandibular arch involves a combination of Shh signalling at sites where teeth are required and antagonism in regions destined to remain edentulous. (Mus musculus) PubMed
79.
Shh is required for expansion, but not the differentiation, of the granule neuron precursor population, and plays a role in the compartmentalization of the cerebellum . (Mus musculus) PubMed
80.
early posterior restriction of Hox gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh; this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes (Mus musculus) PubMed
81.
Data show that Gli2 and Gli3 act together with Sonic hedgehog to regulate neuronal patterning by controlling progenitor cell segregation. (Mus musculus) PubMed
82.
Protein was detected at the gene level with semiquantitative reverse transcriptase-polymerase chain reaction in the epididymis. (Mus musculus) PubMed
83.
Shh-expressing cells and their descendants cannot express Gremlin; proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells which breaks down the Shh-Fgf4 loop and affects limb size (Mus musculus) PubMed
84.
Hedgehog signaling has a role in vascular development (Mus musculus) PubMed
85.
SHH regulates branching morphogenesis and influences differentiation of the peripheral lung mesenchyme required for formation of bronchial and vascular smooth muscle. (Mus musculus) PubMed
86.
Hh signaling is not required to specify digit identities in limb development (Mus musculus) PubMed
87.
length of time of exposure to Shh is critical in the development of the differences between the most posterior digits (Mus musculus) PubMed
88.
Sonic hedgehog controls the proliferation and differentiation of neural crest cells and modulates their responsiveness toward GDNF induction. (Mus musculus) PubMed
89.
essential for the patterning of ventral regions and the generation of cell types that are thought to largely arise from them (Mus musculus) PubMed
90.
transgenic skin developed lesions reminiscent of human basal cell carcinoma (Mus musculus) PubMed
91.
positive Shh signaling through Gli2 is required to generate a sufficient number of granule cell precursors for proper lobe growth (Mus musculus) PubMed
92.
Disp1 has a role in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand (Mus musculus) PubMed
93.
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain (Mus musculus) PubMed
94.
Fgf15 is directly regulated by Shh signaling through Gli proteins in the developing diencephalon and midbrain (Mus musculus) PubMed
95.
Hh signaling is required for proliferation and survival of basal cell carcinomas (Mus musculus) PubMed
96.
a single base pair change within the limb-specific Shh enhancer acts as a genetic basis for preaxial polydactyly (Mus musculus) PubMed
97.
Sonic hedgehog is one of the survival signals provided by follicular dendritic cells to prevent apoptosis in germinal center B cells. (Mus musculus) PubMed
98.
Shh and its mediators Ptc1, Ptc2, and Gli1 were down-regulated only in the lower but not the upper molars of Runx2 and Runx2/Runx3 knockouts. (Mus musculus) PubMed
99.
intron 5 sequence of the Lmbr1 locus contains a major limb-specific Shh enhancer that is necessary for distal limb development (Mus musculus) PubMed
100.
Exclusion of Shh expression from developing primordia is required for the proper development of pharyngeal-derived organs. (Mus musculus) PubMed
101.
analysis of Shh signaling and regulatory gene expression in mouse taste buds (Mus musculus) PubMed
102.
Data suggest that tight control of Hedgehog pathway (Indian hedgehog and Sonic hedgehog) activity throughout embryonic development ensures proper pancreas organogenesis. (Mus musculus) PubMed
103.
Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. (Mus musculus) PubMed
104.
Shh, functioning via Gli1/2, can specify mesodermal cells into the cardiac muscle lineage (Mus musculus) PubMed
105.
Sonic hedgehog is necessary and sufficient for sine oculis-related homeobox 1 expression in posterior limb regions (Mus musculus) PubMed
106.
Data map Short digits to chromosome 5 in a region containing Shh and demonstrate an inversion comprising 11.7 mb that results in almost complete downregulation of Sonic hedgehog expression during embryonic days E9.5-E12.5. (Mus musculus) PubMed
107.
Shh signaling plays multiple roles during development of oligodendrocytes (Mus musculus) PubMed
108.
fibroblast growth factor (FGF8) signalling triggers secretion of membrane-sheathed objects 0.3-5 microm in diameter termed 'nodal vesicular parcels' (NVPs) that carry Sonic hedgehog and retinoic acid (Mus musculus) PubMed
109.
insulin-like growth factor binding protein 6 is a target of Shh signaling in the urogenital sinus (Mus musculus) PubMed
110.
SHH signaling does not act directly on NCCs as a survival factor, but rather acts to restrict the domains that NCCs can populate during early stages (e8.5-10.5) of cardiovascular and craniofacial development. (Mus musculus) PubMed
111.
Angiogenesis within the developing neural tube is dependent on Shh signaling, and mediated, in part, by angiopoietin-1-positive motor neurons. (Mus musculus) PubMed
112.
a balance between Wnt and Shh signaling activities is key in distinguishing between vestibular and auditory cell types (Mus musculus) PubMed
113.
Shh acts as a proliferation and survival factor of satellite cells in the adult muscle. (Mus musculus) PubMed
114.
our results indicate that the Hh signaling pathway is critical to Meckel's cartilage ontogenesis and the rate of chondrogenesis, but not to initial primordium formation. The reliance on Hh signaling is stage dependent. (Mus musculus) PubMed
115.
Shh signaling controls the rapid and patterned expansion of epithelial progenitors through convergent Gli-mediated regulation. (Mus musculus) PubMed
116.
Fu-deficient mice do not exhibit any embryonic phenotypes indicative of perturbed Hh signaling (Mus musculus) PubMed
117.
the mFu homologue is not required for Hh signaling during embryonic development but is required for proper postnatal development, possibly by regulating the CSF homeostasis or ciliary function (Mus musculus) PubMed
118.
REN protein enhances caspase-3 activation and antagonizes the Shh pathway suggestinsg that this gene may represent a restraint of Shh signaling. (Mus musculus) PubMed
119.
Shh expression is limited to a thickened palatal oral epithelium prior to palatal shelf elevation. After palatal shelf elevation above the tongue, Shh is expressed only in small areas of thickened palatal oral epithelium. (Mus musculus) PubMed
120.
The Shh pathway regulates the activation and viability of hepatic stellate cells. (Mus musculus) PubMed
121.
initially, a small population of cells (including quiescent neural stem cells and transit-amplifying cells) responds to Shh in regions undergoing neurogenesis; this population later expands markedly to continuously provide new neurons in the forebrain (Mus musculus) PubMed
122.
Embryonic abnormalities in Shh signaling are linked to postnatal alterations in cortical interneuron composition. (Mus musculus) PubMed
123.
Retinal Shh signalling is required to maintain retinal precursor cell proliferation and to control the timing of retinal ganglion cell development. (Mus musculus) PubMed
124.
cilia have a direct role in Gli2 and Gli3 processing and Shh signal transduction (Mus musculus) PubMed
125.
Shh pathway is important in the murine epididymis for the development of sperm motility and implies a role for Shh signaling in adult epididymal function. (Mus musculus) PubMed
126.
miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb (Mus musculus) PubMed
127.
Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage. (Mus musculus) PubMed
128.
Gli3 functions as a repressor of ventral oligodendrogenesis and ventral oligodendrogenesis is restored in Shh-/-Gli3-/- mutants. (Mus musculus) PubMed
129.
The SHH pathway is activated in the retina during retinal and choroidal neovascularization and is required for retinal angiogenesis. (Mus musculus) PubMed
130.
Raldh2-/- knockout embryos exhibit abnormally low levels of FGF signaling in the craniofacial region, and impaired sonic hedgehog signaling in the ventral diencephalon. (Mus musculus) PubMed
131.
Hedgehog overexpression has a role in a mouse prostate cancer model (Mus musculus) PubMed
132.
Shh may be a regulator of inner ear progenitor cell growth and hair cell generation. (Mus musculus) PubMed
133.
Hedgehog signaling results in a defective cerebellar response in Down's syndrome mice (Mus musculus) PubMed
134.
Fibroblasts derived from Sufu(-/-) embryos showed high Gli-mediated Hh pathway activity. (Mus musculus) PubMed
135.
NF-kappaB activation is essential for induction of Shh and cyclin D1 expression and subsequent placode down growth (Mus musculus) PubMed
136.
Results show that epithelial-mesenchymal signaling and transcriptional events coordinated by sonic hedgehog, partly via Fgf8, is essential for cell survival and tissue outgrowth of the developing first pharyngeal arch. (Mus musculus) PubMed
137.
The level of shh signaling regulates the complexity of cerebellar foliation. (Mus musculus) PubMed
the cholesterol moiety regulates the range and shape of the Shh morphogen gradient by restricting rather than promoting the postrelease spread of Shh across the limb bud during early development (Mus musculus) PubMed
140.
Processing and degradation of Gli2 are suppressed by Shh signaling in vivo; this is the first demonstration of a molecular mechanism by which the Gli2 transcriptional activity is regulated by Shh signaling. (Mus musculus) PubMed
Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions. (Mus musculus) PubMed
143.
Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. (Mus musculus) PubMed
144.
Pbx1/Pbx2 exert a primary hierarchical function on Hox genes, rather than behaving merely as Hox ancillary factors (Mus musculus) PubMed
145.
an isl1/Shh/npn pathway required to affect morphogenesis at the anterior pole of the heart (Mus musculus) PubMed
146.
topically applied Shh gene therapy may have significant therapeutic potential for enhanced wound healing in impaired microcirculation such as occurs in diabetes. (Mus musculus) PubMed
147.
These studies showed that genetic loss of Shh is accompanied by an up-regulation of Indian Hedgehog (Ihh) and maintenance of hedgehog pathway activity. (Mus musculus) PubMed
148.
cholesterol or specific oxysterols are the critical products of sterol synthesis required for Shh pathway signal transduction in medulloblastoma cells (Mus musculus) PubMed
149.
Hedgehog (HH) is necessary for coronary vascular development and activation of HH signaling is sufficient to promote coronary growth and to rescue coronary defects due to loss of fibroblast growth factor (FGF) signaling. (Mus musculus) PubMed
150.
Bapx1 overexpression generates limb anteroposterior patterning defects including induction of Shh signaling and ectopic activation of functions downstream of Shh signaling into the anterior region of the autopod. (Mus musculus) PubMed
151.
Fibroblast growth factors act downstream of SHH to generate ventral telencephalic cell types. (Mus musculus) PubMed
152.
BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc. (Mus musculus) PubMed
153.
investigation of GLI-Kruppel family member GLI1(GLI) protein processing and binding of GLI activators and repressor to SHH target genes provide insight into the molecular mechanisms by which SHH and its GLI family of effectors control renal embryogenesis (Mus musculus) PubMed
154.
Sonic hedgehog (Shh) is a downstream target of the RARbeta2 signalling pathway as it is expressed in the injured DRG of wild-type but not RARbeta null mice. Shh alone cannot induce neurite outgrowth but potentiates RARbeta2 signalling in this process. (Mus musculus) PubMed
155.
SHH morphogen controls gene expression in the digit-forming mesenchyme of mouse limb buds (Mus musculus) PubMed
156.
The cranial base appears to be a skeletal structure in which growth and ossification patterns along its antero-posterior axis are orchestrated by both Ihh and Shh. (Mus musculus) PubMed
157.
Diminished by biomechanical stimulation in vitro and in vivo and thus may play a fundamental role in arterial remodeling and atherogenesis in vivo. (Mus musculus) PubMed
158.
analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 (Mus musculus) PubMed
159.
N-myc is required for medulloblastoma genesis even in the presence of constitutively active signaling from the Shh pathway. (Mus musculus) PubMed
160.
Sonic Hedgehog plays role in apoptosis and proliferation in chondrocytes in premature joints (Mus musculus) PubMed
161.
modulates the expression of a subset of CD28-responsive genes, including cyclin A and B cell translocation gene 2 and potentiates CD3-mediated proliferation and cytokine production by CD4(+) T cells (Mus musculus) PubMed
162.
Sonic hedgehog (Shh) pathway is downregulated in the neural tube in the absence of Hippi, which results in failure to establish ventral neural cell fate. (Mus musculus) PubMed
163.
Point mutations M101116 and M100081 affect the negative regulatory activity of MFCS1, which suppresses anterior Shh expression in developing limb buds. (Mus musculus) PubMed
164.
The results presented in this study implicate p63 in the regulation of the Shh signaling pathway. (Mus musculus) PubMed
165.
data suggest that Boc is essential as a receptor for Shh in commissural axon guidance (Mus musculus) PubMed
166.
beta1 integrins were found to drive the expression of Hedgehogs (Shh) in intestinal epithelial cells in an HNF-3beta (Foxa2)-dependent fashion. (Mus musculus) PubMed
167.
Study investigated the expression of Shh and constituent members of the signalling pathway during early development of the molar tooth root in the mouse and find the presence of transcripts in Hertwig's epithelial root sheath. (Mus musculus) PubMed
168.
The specific, membrane-permeable cGMP-dependent protein kinase G-Ialpha (PKG-Ialpha) inhibitor DT-2 prevents an efficient Shh response, indicating that the effects of cGMP on the Shh response are mediated via PKG. (Mus musculus) PubMed
169.
These results indicate the cooperation of Hedgehog and Ras signaling during the earliest stages of pancreatic ductal adenocarcinoma formation. (Mus musculus) PubMed
170.
Hedgehog transcription factor Gli1 is targeted by Numb for Itch-dependent ubiquitination, which suppresses Hedgehog signals, thus arresting growth and promoting cell differentiation. (Mus musculus) PubMed
171.
These results suggest that Shh directly promotes ALC differentiation, and that Gli1 may be responsible for the signal mediation of Shh. (Mus musculus) PubMed
172.
This study uncovers a multifaceted function for Shh in sculpting and maintaining the integrity and identity of the developing hair follicle. (Mus musculus) PubMed
173.
development of smooth muscle myosin-positive embryonic bladder mesenchyme requires Shh signaling, and the bladder mesenchyme and dorsal (upper) external genitalia derive from Shh-responsive peri-cloacal mesenchyme (Mus musculus) PubMed
174.
These data strongly suggest that Hedgehog production in embryoid bodies limits pancreatic fate acquisition and forms a major obstacle in the specification of pancreatic cells from embryonic stem cell-derived definitive endoderm. (Mus musculus) PubMed
175.
activation of Wnt/beta-catenin signaling up-regulates Shh expression; blocking Shh signaling enhanced papillae formation and was accompanied by an up-regulation of Wnt/beta-catenin signaling, indicating that Shh inhibits the Wnt/beta-catenin pathway. (Mus musculus) PubMed
176.
Low levels of Shh signaling initiate Class I gene transcription, while higher levels restrict the domains of Class I gene expression to intermediate positions of the neural tube through the activation of Class II transcriptional regulators. (Mus musculus) PubMed
177.
This review examines various examples in which biophysical and biomechanical aspects of hedgehog signaling in development are revealed, including use of the mouse whole embryo culture system. (Mus musculus) PubMed
178.
These findings demonstrate crucial roles for Shh signaling in multiple stages of pancreatic carcinogenesis. (Mus musculus) PubMed
179.
Localization of Shh expression by Wnt and Eda affects axial polarity and shape of hairs. (Mus musculus) PubMed
180.
Melanomas require Shh-GLI signaling regulated by interactions between GLI1 and teh RAS-MEK/AKT pathways. (Mus musculus) PubMed
181.
results demonstrate a functional sonic hedgehog(HH) pathway in the follicle and identify granulosa cells as at least one of the potential targets of HH signaling (Mus musculus) PubMed
182.
A proper balance of Gli3 repressor proteins and Gli2/3 activator proteins is required along the length of the dorsoventral axis of the inner ear to mediate graded levels of Shh signaling, emanating from ventral midline tissues. (Mus musculus) PubMed
183.
study shows that protease nexin-1 interacts with low-density lipoprotein receptor-related proteins (LRPs) to antagonize SHH-induced cerebellar granular neuron precursors proliferation & that it inhibits the activity of the SHH transcriptional target GLI1 (Mus musculus) PubMed
184.
Gli-activator targets have roles in sonic hedgehog-mediated neural patterning (Mus musculus) PubMed
185.
elevated ectopic Shh signaling can impair dorsal telencephalic midline morphogenesis, and lead to non-cleavage of midline structures mimicking human Holoprosencephaly with dorsal midline defects (Mus musculus) PubMed
186.
Normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals. (Mus musculus) PubMed
187.
Urothelial Shh signaling plays an important role in bladder smooth muscle formation. (Mus musculus) PubMed
188.
Reactivation of Shh signalling from pre-metaplastic to advanced metaplastic lesions of the stomach and outlines the importance of the Shh pathway as a potential chemoprophylactic target for gastric carcinogenesis. (Mus musculus) PubMed
189.
Patterning of the telencephalon is highly sensitive to alterations in Shh spreading behavior. (Mus musculus) PubMed
190.
Loss of a single Shh allele in a Gas1(-/-) background significantly exacerbated the midline craniofacial phenotype, providing genetic evidence that Shh and Gas1 interact. (Mus musculus) PubMed
191.
Hedgehog signaling is required for maintenance of B and C stem cell populations and for the migration of neurons generated from adult stem cells. (Mus musculus) PubMed
192.
As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. (Mus musculus) PubMed
193.
As the intracellular signal transduction of Shh in neural stem cells is largely unknown, we sought to characterize pathway targets using ligand stimulation and genetic models of activation. (Mus musculus) PubMed
194.
binding of Shh to Ptc1 at primary cilia is coupled to pathway activation by the reciprocal movement of Ptc1 out of the cilia and Smo into the cilia (Mus musculus) PubMed
195.
Shh promotes proliferation and differentiation of adult muscle cells: Involvement of MAPK/ERK and PI3K/Akt pathways. (Mus musculus) PubMed
196.
in Kif3a-deficient mesenchymal tissues both the repressor function of Gli3 transcription factor and the activation of the Shh transcriptional targets Ptch and Gli1 are compromised. (Mus musculus) PubMed
197.
cross-talk between Shh/Gli2 and thyroid hormone in keratinocytes is a pathway by which Shh produces its proliferative effects and offers a potential therapeutic approach to basal cell carcinomas (Mus musculus) PubMed
198.
Several dietary alkaloids are weak inhibitors of hedgehog signaling. (Mus musculus) PubMed
199.
The results indicated Shh signaling pathway is critical for odontoblast and ameloblast differentiation and patterns cusp formation. (Mus musculus) PubMed
200.
Altogether these data indicate that Shh contributes to OPC proliferation and distribution along the ON, in addition to their specification. (Mus musculus) PubMed
201.
processing of Shh in the normal stomach is hormonally regulated, acid-dependent, and mediated by the aspartic protease pepsin A (Mus musculus) PubMed
202.
Hairy and enhancer of split (Hes)1, a principal effector of the Notch pathway, is found to be a target of Sonic Hedgehog in both mesodermal and neural cells. (Mus musculus) PubMed
203.
These data suggest a molecular mechanism through which FGF9 and sonic hedgehog signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa. (Mus musculus) PubMed
204.
Describe novel signal transduction pathway for Shh mediated alterations in cell morphology and migration which may involve leukotriene metabolism. (Mus musculus) PubMed
205.
Multiple pathways in parallel are required for Shh-induced proliferation of mouse embryonic stem cells: the Gli1 pathway, intracellular calcium signaling/protein kinase C, and epidermal growth factor receptor activation. (Mus musculus) PubMed
206.
sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. (Mus musculus) PubMed
207.
that BMP2 opposes Shh mitogenic activity by blocking Nmyc expression. We have identified TIEG-1 (KLF10) as the intermediary factor that blocks Nmyc expression through the occupancy of the Sp1 sites present in its promoter. (Mus musculus) PubMed
208.
Contrary to previous reports, sonic hedghog is not required for dorsal hemisphere separation during corticogenesis. (Mus musculus) PubMed
209.
Sonic hedgehog (Shh) and Fork head box F1 (Foxf1) genes encode regulatory molecules that play a pivotal role in gut and lung morphogenesis. (Mus musculus) PubMed
210.
N-terminal palmitoylation is negatively regulated by Gup1 and this protein may contribute to its varied biological actions of Shh (Mus musculus) PubMed
211.
directly observe, measure, localize and modify notochord-derived Shh ligand in the context of neural patterning, providing several new insights into mechanisms of Shh morphogen action (Mus musculus) PubMed
212.
These data establish a function for the previously described arachidonic acid-dependent Hh pathway in a developmentally relevant model system. (Mus musculus) PubMed
213.
We conclude that Shh signaling, acting through the primary cilia, has a critical role in the expansion and establishment of postnatal hippocampal progenitors. (Mus musculus) PubMed
214.
These results suggest that Hh acts as a mitogen and survival factor during early embryonic stem cell neurogenesis. (Mus musculus) PubMed
215.
Ethanol may impair Shh expression indirectly by activating PKA. (Mus musculus) PubMed
216.
This work shows that Kif3a is essential for Shh-dependent expansion of cerebellar progenitors. (Mus musculus) PubMed
217.
Results suggest that reciprocal changes in sonic hedgehog and BMP4 signaling by retinoic acid may regulate prostatic bud initiation. (Mus musculus) PubMed
218.
Data suggest that Shh controls limb development in two phases: a transient, early patterning phase regulating digit identity, and an extended growth-promoting phase during which precursor mesenchyme expands and is recruited into digit primordia. (Mus musculus) PubMed
219.
Results describe ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Sonic hedgehog signaling. (Mus musculus) PubMed
220.
Shh signaling is required within the dorsal mesocardium for its contribution to the atria. Failure of this addition results in severe AVSD (Mus musculus) PubMed
221.
In contrast to the anterior tongue, soft palate Shh expression was rarely seen before Shh spot appearance. Low-level Shh expression before Shh spot appearance may lower soft palate responsiveness to Shh signaling compared to the anterior tongue. (Mus musculus) PubMed
222.
These results demonstrate that Hh signaling in mature osteoblasts regulates both bone formation and resorption and that inhibition of Hh signaling reduces bone loss in aged mice. (Mus musculus) PubMed
223.
GPC3 acts as a negative regulator of Hedgehog signaling during mammalian development. (Mus musculus) PubMed
224.
IFT-dependent trafficking of Hh pathway components through the cilium is essential for their function in embryonic fibroblasts (Mus musculus) PubMed
225.
A restricted domain of Shh signaling is localized to the arterial adventitia and may play important roles in maintenance of resident vascular smooth muscle cells progenitor cells in the artery wall. (Mus musculus) PubMed
226.
analysis of compound mouse mutants defective in genes comprising the positive Fgf/Shh loop provided genetic evidence that FGF signalling can repress Grem1 expression, revealing a novel Fgf/Grem1 inhibitory loop (Mus musculus) PubMed
227.
Shh signaling plays an important role in development of the neocortex (Mus musculus) PubMed
228.
The ability to modulate the number of neuroblasts leaving the SVZ and reaching the OB through the chemoattractive activity of Shh suggests a novel degree of plasticity in cell migration of this adult stem cell niche. (Mus musculus) PubMed
229.
Data show that retinal ganglion cell-derived Shh signalling isthus necessary for maintenance of astrocyte proliferation, affecting both axo-glial and normal glial cell development in the optic nerve. (Mus musculus) PubMed
230.
In Tp63 mutant mice, clefting defects result from increased Bmp4 signaling acting antagonistically on Fgf8 and Shh, led to a reduction in mesenchymal cell proliferation and increased cell death in specific regions of the facial processes. (Mus musculus) PubMed
These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain. (Mus musculus) PubMed
233.
Shh signaling to distinct cell types differentially regulates coronary artery and vein development. (Mus musculus) PubMed
234.
Selective targeting of Shh machinery to primary cilia confers to astrocyte-like neural precursors the ability to differentially respond to Shh mitogenic signals compared to neighboring cells. (Mus musculus) PubMed
235.
SHH stimulation does not regulate Irs1 transcription but rather stabilizes IRS1 protein by interfering with mTOR-dependent IRS1 turnover and possibly affects Irs1 mRNA translation. (Mus musculus) PubMed
236.
The role of NF-kappaB in SHH expression, and the implications for cancer therapy, are reported. (Mus musculus) PubMed
237.
Tshz3 is required for proximal ureteric smooth muscle cell differentiation downstream of SHH and BMP4. (Mus musculus) PubMed
238.
SHH-dependent and -independent brain tumor growth require phosphoinositide 3-kinase-mammalian target of rapamycin signaling; PTEN has a role in shorter survival time (Mus musculus) PubMed
239.
SHH contributes to the formation of desmoplasia in pancreatic cancer (Mus musculus) PubMed
240.
Systemic administration of a monoclonal antibody against HGF prolonged survival of mice bearing Shh + HGF-induced medulloblastomas by stimulating apoptosis. (Mus musculus) PubMed
241.
characterization of the transcriptional output of a Shh-patterning process in the embryo and a framework for elaborating regulatory networks in the developing limb (Mus musculus) PubMed
242.
The two retinal ganglion cells types are characterised by a differential expression of Shh signalling components and that they respond differently to Shh when challenged in vitro. (Mus musculus) PubMed
243.
cilia are a critical signaling component required for normal hair morphogenesis and are needed on cells in the dermis for reception of signals such as sonic hedgehog (Mus musculus) PubMed
244.
transforming growth factor-beta receptor II has a role in lung epithelial morphogenesis and involves TGF-beta and Sonic hedgehog pathways (Mus musculus) PubMed
245.
Shh signaling regulates Sufu activity by inducing its turnover via the ubiquitin-proteasome system. (Mus musculus) PubMed
246.
Different molecular signalling cascades of Wnt11 and Shh would play crucial roles in specific morphogenesis and pattern formation of CVP during early mouse embryo development. (Mus musculus) PubMed
247.
The brain establishes multiple Sonic hedgehog (SHH) signaling centers within the developing upper jaw. (Mus musculus) PubMed
248.
Bmi1 is required for spontaneous de novo development of a solid tumor arising in the brain and is a key factor required for Hh pathway-driven tumorigenesis (Mus musculus) PubMed
249.
Gli2(P1-4) expression prevents massive cell death and promotes cell proliferation in Shh mutant. (Mus musculus) PubMed
250.
Combined with previous demonstrations of a deficit in mitogenic response to Shh by trisomic cerebellar granule cell precursors, these results implicate common cellular and molecular bases of multiple Down syndrome phenotypes. (Mus musculus) PubMed
251.
These results suggest that chromosome conformation dynamics at the Sonic hedgehog (Shh) locus allow transient pulses of Shh transcription. (Mus musculus) PubMed
252.
maintenance of a viable population of PrCP cells by Shh signal is an essential process in development of the midline of the brain and craniofacial structures (Mus musculus) PubMed
253.
the dynamic interplay of canonical Wnt/beta-catenin signaling and Shh may orchestrate floor plate neurogenesis or a lack thereof (Mus musculus) PubMed
254.
Shh stimulation of progenitor proliferation and cell diversification requires Gli2 and Hes1 activity. (Mus musculus) PubMed
255.
Wnt/beta-catenin signaling relayed through Shh and Bmp signals is the principal regulatory mechanism underlying the HF cell fate change. (Mus musculus) PubMed
256.
Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism. (Mus musculus) PubMed
257.
An interplay between retinoic acid, Fgf and Shh signalling is likely to be an important mechanism underpinning the tight regulation of caudal embryonic development. (Mus musculus) PubMed
258.
new roles for metalloproteases, including but not restricted to ADAM17, and for HS-proteoglycans in Hedgehog signaling. (Mus musculus) PubMed
259.
findings suggest a functional collaboration between the miR-17 approximately 92 cluster and the SHH signaling pathway in the development of MBs in mouse and man (Mus musculus) PubMed
260.
Mammalian Smo translocates to the primary cilium in response to Sonic hedgehog (Shh) ligand-mediated signaling (Mus musculus) PubMed
261.
Alteration of the extracellular environment through trypsin treatment can have profound effects on digit patterning. These effects appear to be mediated by the induction of Shh in host tissues and by ectopic apical ectodermal ridge formaion. (Mus musculus) PubMed
262.
primary cilia exert a specific negative regulatory effect on Shh activity that functions to repress tooth formation and thus determine tooth number (Mus musculus) PubMed
263.
Tulp3 is a novel negative regulator of the Shh pathway. (Mus musculus) PubMed
264.
the anteroposterior grading of GLI3 activity by the action of SHH is supported by a prototype patterning, which regulates Gli3 independently from SHH. (Mus musculus) PubMed
265.
Shh signaling is critical for early stage sweat gland development. (Mus musculus) PubMed
266.
Shh, by signaling directly to the developing thymocyte, is a negative regulator of pre-TCR-induced differentiation from double-negative to double-positive thymocytes (Mus musculus) PubMed
267.
TULP3 is required proper for Shh-dependent limb patterning. (Mus musculus) PubMed
268.
These results point out that not all the midbrain neuronal populations are dependent on Shh for their maintenance. (Mus musculus) PubMed
269.
Shh signaling plays a central role in coordinating the reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth (Mus musculus) PubMed
270.
This work uncovers a novel role for Tulp3 as a negative regulatory factor in the hedgehog pathway. (Mus musculus) PubMed
271.
during development of the sympathetic nervous system, Shh is required for patterning of the ganglia but not for neuronal or glial differentiation (Mus musculus) PubMed
272.
Sonic hedgehog, which is normally expressed in ventral and rostral borders of the embryonic thalamus, plays a crucial role in patterning progenitor domains throughout the thalamus. (Mus musculus) PubMed
273.
Shh is required in the pulmonary endoderm for atrial septation. Therefore, Hh signaling from distinct pulmonary and pharyngeal endoderm is required for inflow and outflow septation, respectively. (Mus musculus) PubMed
274.
Targeted deletion of the pharyngeal epithelium specific CNCS results in loss of endogenous Shh expression in the pharynx and postnatal lethality owing to hypoplasia of the soft palate, epiglottis and arytenoid (Mus musculus) PubMed
275.
FGF activity in the limb is not only responsible for maintaining posterior-specific Shh expression, but it also acts via Etvs to prevent inappropriate anterior expansion of Shh. (Mus musculus) PubMed
276.
ETV4 and ETV5 act downstream of FGF signaling to inhibit Shh expression in the anterior limb bud. (Mus musculus) PubMed
277.
Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A (Mus musculus) PubMed
278.
beyond its well established dorso-ventral patterning function through a Gli3-derepression mechanism, Shh signaling is additionally required to promote the timely appearance of motor neuron progenitors in the developing spinal cord. (Mus musculus) PubMed
279.
Cx43 knock-out mice developed syndactylies due to reduced expression of Shh and Bmp2. (Mus musculus) PubMed
280.
the neural Shh coordinates anteroposterior and dorsoventral patterning in the hypothalamus and in the diencephalon-telencephalon junction. Also coordinates mediolateral hypothalamic patterning. (Mus musculus) PubMed
281.
HnRNP U binding to the 5'-UTR of the Shh facilitates gene expression during limb development. (Mus musculus) PubMed
282.
Results provide evidence that HPE associated with this mutation can be mechanistically explained by a severely reduced binding of SHH to GAS1. (Mus musculus) PubMed
283.
Klf6-deficiency leads to elevated levels of hedgehog pathway components (Shh, Ptc, and Gli) and loss of their localized expression, which in turn causes impaired lateral branching. (Mus musculus) PubMed
284.
Data show that BMP7 and SHH activate Pax2 expression in mouse retinal astrocyte precursors in vitro, and that the interaction of both pathways with TLX relieves the repression of Pax2 expression in mouse retinal astrocytes. (Mus musculus) PubMed
285.
The SHH pathway is activated in a normal wound, and its reduction results in impaired NO function and wound healing in diabetes. (Mus musculus) PubMed
286.
Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia. (Mus musculus) PubMed
287.
Results show that Hh pathway activation may contribute to the local expansion of pro-fibrogenic iNKT cell populations during certain types of fibrosing liver damage. (Mus musculus) PubMed
288.
Shh protein promotes porcine oocyte maturation and early embryo development. (Mus musculus) PubMed
289.
Hedgehog protein(s) is identified as an hematopoietic stem cells inducing signal. (Mus musculus) PubMed
290.
Shh signaling regulates hindbrain Choroid plexuses epithelium (hChPe) progenitor proliferation and hChPe expansion through late embryonic development. (Mus musculus) PubMed
291.
Shh-mediated epithelial-mesenchymal transition in ductular cells contributes to the pathogenesis of cirrhosis in nonalcoholic fatty liver disease. (Mus musculus) PubMed
292.
Liver X receptors (LXRs), members of the nuclear hormone receptor family, are identified as previously unrecognized negative regulators of Hh signaling. (Mus musculus) PubMed
293.
Kif7 is a core regulator of Shh signaling that may also act as a ciliary motor. (Mus musculus) PubMed
294.
Proinflammatory stimuli activate sonic hedgehog protein-expressing reactive astrocytes, whereas inhibition of inflammation-induced reactive gliosis abolishes sonic hedgehog protein activation after acute brain injury. (Mus musculus) PubMed
295.
The Shh pathway plays a role in the proliferation of neural progenitor cells induced by ischemia/hypoxia and might participate in injury remodeling. (Mus musculus) PubMed
296.
Recovery of Lama1 expression or addition of exogenous laminin-111 to Shh(-/-);Gli3(-/-) embryos restores the myotomal basement membrane, demonstrating that laminin-111 is necessary and sufficient to initiate assembly of the myotomal basement membrane. (Mus musculus) PubMed
297.
in hypertrophic chondrocytes, HS-assisted, TG-mediated Hh oligomerization modulates signaling via enhanced protein signaling activity (Mus musculus) PubMed
298.
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools. (Mus musculus) PubMed
299.
Study shows that BMP activity negatively regulates Shh transcription and that a BMP-Shh negative-feedback loop serves to confine Shh expression. (Mus musculus) PubMed
300.
Rfx4 is a regionally specific transcriptional regulator of ciliogenesis and thus is also a regionally specific modulator of Shh signaling during development of the central nervous system. (Mus musculus) PubMed
301.
The Shh signaling pathway may influence both form-deprivation myopia and the postnatal growth of eyes with normal visual input. (Mus musculus) PubMed
302.
Multiphasic and tissue-specific roles of Shh in cloacal septation and external genitalia development are reported. (Mus musculus) PubMed
303.
Temporal and spatial dissection of Shh signaling in genital tubercle development are reported. (Mus musculus) PubMed
304.
Dosage-dependent hedgehog signals integrated with Wnt/(beta)-catenin signaling regulate external genitalia formation as an appendicular program. (Mus musculus) PubMed
305.
findings show Atoh1 regulates the signal transduction pathway of Sonic Hedgehog, an extracellular factor essential for granule neuron precursor proliferation & demonstrate that deletion of Atoh1 prevents cerebellar neoplasia in a model of medulloblastoma (Mus musculus) PubMed
306.
Within the rostral hindbrain, the Shh-activated homeodomain proteins Nkx2.2 and Nkx6.1 cooperate to induce the closely related zinc-finger transcription factors Gata2 and Gata3. (Mus musculus) PubMed
307.
Shh stimulates oligodendrocyte progenitor specification and simultaneously restricts the ventral extension of the astrocyte progenitor domain and reduces astrocyte development. (Mus musculus) PubMed
308.
Shh maintains bud development by localizing the dermal feather progenitors. (Mus musculus) PubMed
309.
Shh-expressing cells and their descendants cannot express Gremlin; proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells which breaks down the Shh-Fgf4 loop and affects limb size (Mus musculus) PubMed
310.
Noggin and Shh are both required in order to change the future amnion into a feather-bearing skin. (Mus musculus) PubMed
311.
Shh is sileced in the right side of the Hensen's node by Pcl2 (Mus musculus) PubMed
312.
Hedgehog signaling has a role in vascular development (Mus musculus) PubMed
313.
Sonic hedgehog (Shh) and FGF8 have strong synergistic effects on chondrogenesis in vitro and promote outgrowth and chondrogenesis in vivo, suggesting a very specific role in producing elongated beak structures during chick facial development. (Mus musculus) PubMed
314.
Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly. (Mus musculus) PubMed
315.
FGF signaling maintains cyclin D2 in the immature caudal neural epithelium, while Shh activates cyclin D1 in the neural groove. (Mus musculus) PubMed
316.
the hedgehog (Hh) pathway plays a role in maintenance of the retina pigmented epithelium (Mus musculus) PubMed
317.
Overexpression of Shh in facial motor neurons of axotomized neonatal rats may promote neuronal survival. Adenovirus-mediated overexpression of chicken Shh transiently rescues axotomy-induced neuronal cell death for 3-5 d after axotomy. (Mus musculus) PubMed
318.
Data indicate that the rostral neural tube environment contains a signal different from both Sonic hedgehog and retinoic acid that acts on motoneuron differentiation. (Mus musculus) PubMed
319.
Sonic Hedgehog signaling plays a role in the patterning of the ventral neural tube (Mus musculus) PubMed
320.
Sonic hedgehog is necessary and sufficient for sine oculis-related homeobox 1 expression in posterior limb regions (Mus musculus) PubMed
321.
Thalamic development is induced by SHH in the chick embryo. (Mus musculus) PubMed
322.
interactions between Sonic hedgehog (Shh) and bone morphogenetic protein 2 (Bmp2) signaling during feather barb ridge morphogenesis (Mus musculus) PubMed
323.
miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb (Mus musculus) PubMed
324.
Data suggest that Sonic hedgehog (Shh) signaling regulates patterning, proliferation and survival of neural cells, thus Shh/Gli activity couples these separate cellular responses of progenitors to coordinate neural development. (Mus musculus) PubMed
325.
Shh contributes to CDC25B transcriptional activation in the neural tube both of chick and mouse embryos (Mus musculus) PubMed
326.
Results suggest that sonic hedgehog derived from the ventral foregut endoderm ensures the survival of neural crest cells at a critical stage of branchial arch development. (Mus musculus) PubMed
327.
Our data show, for the first time, that Shh can regulate the expression not only of other gene regulatory factors, but also of Cad7, a morphoregulatory molecule that plays a role in axon elongation and neural circuit formation. (Mus musculus) PubMed
328.
Hedgehog-regulated localization of Vax2 controls eye development (Mus musculus) PubMed
329.
Sonic hedgehog in the pharyngeal endoderm controls arch pattern via regulation of Fgf8 in head ectoderm. (Mus musculus) PubMed
330.
mechanisms showing how FGF2 and Shh signaling are interdependent during retina regeneration (Mus musculus) PubMed
331.
regulation between Fgf19 and the signaling molecules of the isthmic and zli organizers: Fgf8 and Shh, respectively. (Mus musculus) PubMed
332.
Shh and Fgf8 regulate each other's expression in this frontonasal organizer by either blocking or ectopically activating these pathways. (Mus musculus) PubMed
333.
Shh can regulate both cell number and the distribution of cell types in dorsal root gangia and plays an important role in the specification, patterning and pathfinding of sensory neurons. (Mus musculus) PubMed
334.
endoderm zone I ablation was rescued by Shh-loaded beads, whereas inhibition of Shh signalling suppressed mesethmoid formation (Mus musculus) PubMed
335.
Shh-producing cells create a zone of polarizing activity for the structures deriving from them (Mus musculus) PubMed
336.
Results indicate that the Smo-induced Galpha(i) activity plays an insignificant role in the regulation of Gli3 processing and Shh-regulated neural tube patterning. (Mus musculus) PubMed
337.
Shh continues to be expressed in tissues surrounding the prospective adenohypophysis. (Mus musculus) PubMed
338.
Varying levels of Shh signaling act in a morphogen-like manner to elicit differing responses from somitic cells, Pax3 and Nkx3.2 set up mutually repressing cell fates that promote either dermomyotome/myotome or sclerotome differentiation, respectively. (Mus musculus) PubMed
339.
SHH is exclusively expressed in the conjunctival (scleral) papillae and not in the mesenchyme. (Mus musculus) PubMed
340.
The brain establishes multiple Sonic hedgehog (SHH) signaling centers within the developing upper jaw. (Mus musculus) PubMed
341.
Hth expression in the fly eye imaginal disc is primarily repressed by the transforming growth factor beta family protein decapentaplegic, whereas Meis2 expression in the chick eye cup is terminated in response to sonic hedgehog signaling. (Mus musculus) PubMed
342.
Alteration of the extracellular environment through trypsin treatment can have profound effects on limb patterning. These effects appear to be mediated by the induction of Shh in host tissues and by ectopic apical ectodermal ridge formaion. (Mus musculus) PubMed
343.
findings show that cadherin-20 expression in motor neurons is regulated by Sonic hedgehog in a time-dependent manner (Mus musculus) PubMed
344.
tested whether reducing hedgehog signaling caused redeployment of the dorsal-ventral axis of the injured neural tube, allowing generation of new neural crest-like cells (Mus musculus) PubMed
345.
in hypertrophic chondrocytes, HS-assisted, TG-mediated Hh oligomerization modulates signaling via enhanced protein signaling activity (Mus musculus) PubMed
346.
Study shows that BMP activity negatively regulates Shh transcription and that a BMP-Shh negative-feedback loop serves to confine Shh expression. (Mus musculus) PubMed
347.
Domestic cats which manifest extra digits, contain mutations within the limb-specific cis-regulator for SHH called ZRS which caused ectopic expression of the signaling molecule Sonic Hedgehog (SHH) in the developing limb bud. (Mus musculus) PubMed
348.
Data show that rugae function as SHH signaling centers to pattern the elongating palatal shelves. (Mus musculus) PubMed
349.
Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons (Mus musculus) PubMed
350.
findings support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development (Mus musculus) PubMed
351.
controls the fate of CNC cells through tissue-tissue interaction and plays a crucial role during palatogenesis (Mus musculus) PubMed
352.
Mks1 is required for ciliogenesis and shh signaling in mouse model of human meckel syndrome. (Mus musculus) PubMed
353.
HH signaling suppresses peripheral neuroblastic tumor growth by promoting differentiation along alternative neural crest pathways (Mus musculus) PubMed
354.
Fuz plays an important role in cilia formation, Hh signal transduction, and embryonic development in mammals. (Mus musculus) PubMed
355.
Differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling. (Mus musculus) PubMed
356.
Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors. (Mus musculus) PubMed
357.
Pancreatic duct glands may provide a link between Shh, mucinous metaplasia, and neoplasia. (Mus musculus) PubMed
358.
Loss of Shh in the adrenocortex led to reduced proliferation of capsular cells and a 50-75% reduction in adrenocortex thickness and adrenal size. (Mus musculus) PubMed
359.
In the stomachs of adult mice, loss of Shh from parietal cells results in hypochlorhydria and hypergastrinemia. (Mus musculus) PubMed
360.
IL-1beta suppresses Sonic Hedgehog gene expression in parietal cells by inhibiting acid secretion and subsequently the release of intracellular calcium. (Mus musculus) PubMed
361.
SHH protein and targets of Hh signaling are present in the limb bud ectoderm including the apex of the bud. (Mus musculus) PubMed
362.
cross-talk between interferon-gamma and Shh highlights a potential importance of this immune mediator in the pathogenesis of human developmental and psychiatric disorders (Mus musculus) PubMed
363.
Cdx2 reduced Shh expression by binding to the unmethylated Shh promoter in the intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach. (Mus musculus) PubMed
364.
The ventral and segmented expression of Sox9 in tracheal primordia under Shh modulated by Bmp4 and Noggin thus determine where and when tracheal cartilage develops. (Mus musculus) PubMed
365.
Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain (Mus musculus) PubMed
366.
the Shh pathway has a role in tumors induced by hyperactive Wnt signaling (Mus musculus) PubMed
367.
Midline signaling regulates kidney positioning but not nephrogenesis through Shh. (Mus musculus) PubMed
368.
Shh is required for vascular outgrowth in the hindbrain choroid plexus. (Mus musculus) PubMed
369.
study identifies Shh as an essential proliferative signal for the cerebellar ventricular germinal zone and reveals a transventricular source of Shh in regulating neural development. (Mus musculus) PubMed
370.
Hh proteins act as paracrine mitogens to promote the expansion of adjacent mesenchymal progenitors, including those of the smooth muscle compartment. (Mus musculus) PubMed
371.
Taken together, our data suggest that SHH plays an important role in the promotion of auditory hair cell differentiation via the Math1-Brn3.1 signaling pathway. (Mus musculus) PubMed
372.
primary cilia regulate the level of Hh activation, and that ablation of these cellular organelles is sufficient to cause significant up-regulation of the Hh pathway in pancreata of mice overexpressing GLI2 (Mus musculus) PubMed
373.
data demonstrate that the Shh pathway is functionally important for adult skeletal muscle regeneration and displays pleiotropic angiogenic and myogenic potentials in post-natal life (Mus musculus) PubMed
374.
study uncovers essential components of the transcriptional machinery and key interactions that set-up limb bud asymmetry upstream of establishing the SHH signaling limb bud organizer (Mus musculus) PubMed
375.
Results sugges that Sonic hedgehog concentration affects mesenchymal proliferation and patterning of bladder smooth muscle. (Mus musculus) PubMed
376.
Data show that BMP4 and Shh constitute a dorsal-ventral signaling system together with FGF8. (Mus musculus) PubMed
377.
A balance between different pathways ensures the robustness of timely somite formation and notochord-derived Shh is a component of the molecular network regulating the pace of the somitogenesis clock. (Mus musculus) PubMed
378.
elongation of dental epithelial cells, HERS, is essential for root development and that TGF-beta/BMP signaling relies on a Smad4-dependent signaling mechanism to regulate Nfic expression via Shh signaling to control root formation. (Mus musculus) PubMed
379.
Shh affects post-crossing axon guidance both directly and indirectly by regulating Wnt function. (Mus musculus) PubMed
380.
Results suggest that MIM promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh signaling during tissue regeneration. (Mus musculus) PubMed
381.
Shh/Gli2 signaling stimulates vascular smooth muscle cell proliferation via regulation of the G(1) cyclin-retinoblastoma axis. (Mus musculus) PubMed
382.
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. (Mus musculus) PubMed
383.
Shh acts as a negative-feedback regulator of Wnt signaling (Mus musculus) PubMed
384.
The majority of upper jaw shape variation can be explained by progressive changes in the spatial organization and mitotic activity of midfacial growth zones controlled by SHH signaling. (Mus musculus) PubMed
385.
Collectively, our findings demonstrate a role for neuron-derived Shh in regulating specific populations of differentiated astrocytes. (Mus musculus) PubMed
386.
SHH, which is produced by the differentiating progeny of the stem cells, signals to several regions of the incisor; Hh signaling is not required for stem cell survival but is essential for the generation of ameloblasts. (Mus musculus) PubMed
387.
Dynamic changes in the temporal responses to Sonic hedgehog in the developing ventral telencephalon occur through alterations in progenitor competence. [review] (Mus musculus) PubMed
388.
alpha(2B)-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog-mediated proliferation of mesenchymal cells and thus prevent respiratory failure (Mus musculus) PubMed
389.
Data show that the putative Wnt/beta-catenin targets Sonic hedgehog and JAG2 control beta-catenin signaling in the adult tongue epithelium, a function that is partially lost in lingual squamous cell carcinoma. (Mus musculus) PubMed
390.
Bmi1 directly regulates p21Waf1/Cip1 expression through direct binding to its promoter and may therefore represent a key mechanism mediating the role of Shh in postnatal cerebellar neurogenesis. (Mus musculus) PubMed
391.
that Shh/Gli2 signaling controls the diencephalic expression of Bone morphogenetic protein 4 (Bmp4) and Fibroblast growth factor 8 (Fgf8), two genes that are known to play critical roles in patterning and growth of Rathke's pouch. (Mus musculus) PubMed
392.
These data establish that dynamic, non-graded changes in responding cells are essential for Shh morphogen interpretation. (Mus musculus) PubMed
393.
Secretagogues that stimulate gastric acid secretion induce Shh gene expression through increased Ca(2+)(i)-release and PKC activation (Mus musculus) PubMed
394.
This study demonstrates that Hedgehog signaling regulates E-cadherin expression that is required for the maintenance of F-actin cortical expression and stability of tight junction protein ZO-1. (Mus musculus) PubMed
395.
role of two crucial morphogens, fibroblast growth factor 10 and sonic hedgehog, in the formation of periodically alternating cartilaginous and non-cartilaginous domains in the ventral mesenchyme (Mus musculus) PubMed
396.
These data suggest that Hedgehog signaling directs the lineage differentiation of mesodermal stem cells and represents a promising strategy for skeletal tissue regeneration. (Mus musculus) PubMed
397.
These data demonstrate that balanced Shh signaling is critical for maintaining regional boundaries within the dorsal midline telencephalic organizing center. (Mus musculus) PubMed
398.
Results suggest a model whereby Shh signaling from distinct spatial and temporal domains in the diencephalon exhibits unique and overlapping functions in the development of discrete classes of thalamic interneurons. (Mus musculus) PubMed
399.
These findings demonstrate a novel Shh pathway that regulates the actin cytoskeleton via Tiam1-Rac1 activation. (Mus musculus) PubMed
400.
The hedgehog signaling pathway at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA. (Mus musculus) PubMed
401.
Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway. (Mus musculus) PubMed
402.
Bmp-4, Shh and Wnt-5a gene expressions may act together on the epithelial-mesenchymal interactions during early mouse craniofacial development, such as odontogenesis, neuronal development, jaw ossification, palatogenesis and tongue formation. (Mus musculus) PubMed
403.
Data show that Shh induces betaArr1 accumulation and localization to the nucleus, where it participates in enhancing expression of the cyclin dependent kinase (cdk) inhibitor p27, whose accumulation eventually drives CGNP cell cycle exit. (Mus musculus) PubMed
404.
These data suggest a direct link between Six3 and Shh regulation during normal forebrain development and in the pathogenesis of holoprosencephaly.[SBE2] (Mus musculus) PubMed
405.
A differential contribution of Shh-expressing and Shh-responding cells to medial amygdala neuronal diversity is revealed, as well as the function of homeobox gene Nkx2-1 in the development of an important limbic system structure. (Mus musculus) PubMed
406.
These findings pertinent to the etiology of tumor metabolism also underscore the key role of the Shh-->E2F1-->fatty acid synthase axis in regulating de novo lipid synthesis in cancers. (Mus musculus) PubMed
407.
these data suggest that the spatiotemporal patterning of cell proliferation and Shh expression areas in the epithelium regulates the crown width and cusp formation of the tooth (Mus musculus) PubMed
408.
GLI3 and Hh signaling controls Kit and Hcn3 expression and ureter peristalsis (Mus musculus) PubMed
409.
Data show that IFT122 controls the ciliary localization of Shh pathway regulators in different ways. (Mus musculus) PubMed
410.
the proliferative effects of Shh on CGNPs are mediated by the combined activity of Galpha(i2) and Galpha(i3) proteins. (Mus musculus) PubMed
411.
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder (Mus musculus) PubMed
412.
Hoxd13 and Sall1 are syn-expressed in the posterior region of early chick wing buds together with 6 novel genes which are likely to be functionally related and represent secondary targets of Shh signalling. (Mus musculus) PubMed
413.
findings reveal unique developmental functions for eIF4E and S6 kinase wherein their activity is specifically uncoupled by mitogenic Shh signaling (Mus musculus) PubMed
414.
Shh stimulation promotes the self-renewal capacity of leukemia stem cells in some cell lines. (Mus musculus) PubMed
415.
These studies provided further insights into the gene regulatory interactions among Foxa1, Foxa2 and Shh in ventral midbrain progenitors that contribute to midbrain patterning. (Mus musculus) PubMed
416.
Finding that Shh regulates cell number by controlling the length of specific cell cycle phases identifies a novel mechanism by which Shh elaborates pattern during appendage development. (Mus musculus) PubMed
417.
The extra-toes spotting mouse embryos have ectopic Shh and Ptch1 expression in the anterior limb. In addition, anterior limb buds show aberrant Gli3 processing, consistent with perturbed SHH/GLI3 signaling. (Mus musculus) PubMed
418.
role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium (Mus musculus) PubMed
419.
We propose a new reaction-diffusion model in which Wnt, Shh and Sostdc1 act as the activator, mediator and inhibitor, respectively, and confirm that such interactions can generate the tooth pattern of a wild-type mouse. (Mus musculus) PubMed
420.
SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. (Mus musculus) PubMed
421.
role of Shh signalling in patterning the pharyngeal pouches and in restricting the expression of the parathyroid marker Gcm2 in the pharyngeal epithelium (Mus musculus) PubMed
422.
These results place MDM2 at a major nexus between the p53 and Shh signaling pathways in granular neuronal precursor. (Mus musculus) PubMed
423.
Arl13bhnn mutants have abnormal ventral neural tube patterning due to disrupted sonic hedgehog signaling; in addition, dorsal patterning defects occur from abnormal bone morphogenetic protein signaling. (Mus musculus) PubMed
424.
Data show that it is primarily Hh-induced VEGF-A that promotes angiogenesis in vitro and augments tumor-derived VEGF to promote angiogenesis in vivo. (Mus musculus) PubMed
425.
Data suggest that the formation of the notochord sheath requires hedgehog signaling and that the sheath is essential for maintaining the rod-like structure of the notochord during early embryonic development. (Mus musculus) PubMed
426.
Correct corticogenesis is an outcome of the interplay between the Hh and Notch signaling pathways. (Mus musculus) PubMed
427.
Results suggest role of Shh-Gli signaling in sexually dimorphic development in embryos. Shh gene inactivation at sexual differentiation stage induces female-like structure of genital tubercle in male embryos. (Gli = GLI-Kruppel family member protein) (Mus musculus) PubMed
428.
Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog. (Mus musculus) PubMed
429.
Shh protein promotes porcine oocyte maturation and early embryo development. (Mus musculus) PubMed
430.
These results show that Shh is necessary and sufficient for the specification of adult ventral neural stem cell. (Mus musculus) PubMed
431.
Shh expression in a rudimentary tooth offers new insights into development of the mouse incisor (Mus musculus) PubMed
432.
Nerve-derived form defines a niche for hair follicle stem cells capable of becoming epidermal stem cells (Mus musculus) PubMed
433.
Sna1 is induced in conjunction with Shh pathway activation in primary murine tumors. Sna1 induces N-Myc in neural cells. (Mus musculus) PubMed
434.
Data show that Brg is required both for repression of the basal expression and for the activation of signal-induced transcription of Shh target genes. (Mus musculus) PubMed
435.
Shh and wingless-related Wnt-7a interfere differently with the process of neuronal differentiation by promoting distinct stages of neuronal differentiation in neonatal neural stem cells. (Mus musculus) PubMed
436.
Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. (Mus musculus) PubMed
437.
We employed genetic inducible fate mapping to investigate whether precursors that express Shh or transduce Shh signaling at different time points (Mus musculus) PubMed
438.
essential function for Skor2 as a novel transcriptional regulator in Purkinje cells that acts upstream of Shh during cerebellum development (Mus musculus) PubMed
439.
Data indicate that PACAP acts in embryoid bodies to inhibit Hh pathway-mediated ventral neuron specification. (Mus musculus) PubMed
440.
This work uncovers a functional cascade that involves Shh, miR-206 and BDNF to coordinate ASM formation and innervation. (Mus musculus) PubMed
441.
Data demonstrate that the timing of gene expression along with the genetic lineage (Shh or Gli1) within the neural progenitors segregate mDA neurons into distinct spatial domains. (Mus musculus) PubMed
442.
Increased expression of sonic hedgehog in the keratinocytes of the VDR-null mice activates the hedgehog pathway, predisposing the skin to the development of both malignant and benign epidermal neoplasms. (Mus musculus) PubMed
443.
astrocytes secrete SHH and blood-brain barrier(BBB)ECs express Hedgehog receptors, which together promote BBB formation and integrity;Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks (Mus musculus) PubMed
444.
Data show that in Shh;Gli3 mutants, adjacent rings of Fgf8 and Wnt3a expression are induced in the diencephalon at the ZLI, reminiscent of the Fgf8/Wnt1-expressing isthmic organizer. (Mus musculus) PubMed
445.
relationship between Shh and insulin-like growth factor I (IGF-I) was examined with regard to myogenic differentiation via signaling pathways (Mus musculus) PubMed
446.
Data indicate that in the absence of cooperating mutations, Hh ligand overexpression in the mature exocrine pancreas is insufficient to induce neoplasia. (Mus musculus) PubMed
447.
Using an in vivo reporter of Shh signaling, mouse genetics, and systems modeling, study shows that a spatially and temporally changing gradient of Shh signaling is interpreted by the regulatory logic of a downstream transcriptional network. (Mus musculus) PubMed
448.
role in the transition from double-positive to single-positive thymocyte (Mus musculus) PubMed
449.
Shh is required for primary and secondary hair down-growth and full secondary hair length, but is not itself sufficient to replace Eda or make fully normal secondary hair. (Mus musculus) PubMed
450.
show that Sostdc1, a secreted inhibitor of the Wnt pathway, is a downstream target of Shh and hypothesize that the interaction of Wnt, Shh and Sostdc1 is a pivotal mechanism controlling the spatial patterning of palatal rugae (Mus musculus) PubMed
Shh expression takes the form of periodic stripes under a Turing mechanism operating at growth zones in the mammalian palate. (Mus musculus) PubMed
453.
Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation (Mus musculus) PubMed
454.
It was shown that Sox2 and Sox3 are dose-dependent regulators of sonic hedgehog transcription that directly bind and activate a long-range Shh forebrain enhancer. (Mus musculus) PubMed
455.
These results demonstrate that Shh is expressed in postsynaptic target cells while Boc is expressed in a complementary population of presynaptic input neurons, and they function to guide the formation of cortical microcircuitry (Mus musculus) PubMed
456.
Data show that regulation of asymmetric Dan expression by SHH and BMP4 in Hensen's node. (Mus musculus) PubMed
457.
Estradiol improves the recovery of injured nerves by downregulating the Shh inhibitor hedgehog-interacting protein and increasing Shh-induced angiogenesis. (Mus musculus) PubMed
458.
A subset of precursors in the embryonic cortex expressing an elevated level of Akt1 can respond to lower concentrations of hedgehog protein (Shh) than neighboring precursors, resulting in increased expression of epidermal growth factor receptors. (Mus musculus) PubMed
459.
Sonic hedgehog signaling during adrenal development. (Mus musculus) PubMed
460.
Helicobacter pylori induces release of Shh from the stomach; Shh acts as a macrophage chemoattractant during initiation of gastritis. (Mus musculus) PubMed
461.
Our data are consistent with the possibility for a role of SoxE group genes downstream of Hh signaling on Muller cell development. (Mus musculus) PubMed
462.
Targets of RBPJ/N1ICD in cortical neural stem cell at a genome-wide level, were identified (Mus musculus) PubMed
463.
Findings suggest that dermal Shh signaling Study regulates specific dermal papillae signatures to maintain dermal papillae maturation while maintaining a reciprocal Shh-Noggin signaling loop to drive hair follicle morphogenesis. (Mus musculus) PubMed
464.
Cav1-deficient fibroblasts displayed increased ShhN expression, which heterotypically enhanced the Shh signaling pathway in melanoma cells. (Mus musculus) PubMed
465.
BBS genes modulate Shh pathway activity and interact genetically with the intraflagellar transport (IFT) pathway to play a role in mammalian development. (Mus musculus) PubMed
466.
During postnatal growth of the mouse, Sonic hedgehog (Shh) signaling from the nucleus pulposus (NP) cells controls many aspects of growth and differentiation of both the NP cells. (Mus musculus) PubMed
467.
Hh is an essential modulator of VEGF expression during developmental angiogenesis. (Mus musculus) PubMed
468.
a novel, VEGF-independent, clinically relevant, pro-angiogenic factor, CYR61, that is a transcriptional target of Hh-GLI signaling (Mus musculus) PubMed
469.
These findings indicate a reciprocal interaction between ATF5 and Shh in which Shh stimulates ATF5 expression and in which ATF5 contributes to Shh-stimulated cerebellar granule neuron progenitor cell expansion. (Mus musculus) PubMed
470.
This is the first demonstration that Shh signaling-mediated multidirectional repulsion of serotonergic RST axons maintains spatial axon pathfinding in the developing spinal cord. (Mus musculus) PubMed
471.
the increased Shh activity seen in partial loss-of-function IFT-A mutants may be a result of decreased ciliary ACIII and that the loss of Shh activity in the absence of IFT-A is a result of severe disruptions of cilia structure and protein trafficking. (Mus musculus) PubMed
472.
Expression of Yap activated Shh but not Wnt or Notch signaling activity during neuronal differentiation. (Mus musculus) PubMed
473.
beta-catenin has multiple functions during thalamic neurogenesis and that both Shh and beta-catenin pathways are important for specifying distinct types of thalamic progenitor cells (Mus musculus) PubMed
474.
A fate map of the hypothalamus is defined, based on expression of sonic hedgehog (Shh) in the hypothalamic progenitor zones. Large neurogenic Shh-expressing progenitor domains of the ventral diencephalon are continuous with those of the midbrain. (Mus musculus) PubMed
475.
The transcription factor FOXA2 can execute the full midbrain and spinal cord floor plate program via HH-independent and dependent mechanisms. (Mus musculus) PubMed
476.
interruption of a non cell-autonomous mode of sonic hedgehog (Shh) signaling originating from dopaminergic neurons causes deficits reminiscent of Parkinson's disease. (Mus musculus) PubMed
477.
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types. (Mus musculus) PubMed
478.
Fgfr2IIIb-/- mouse embryos exhibit no disruptions in Shh expression at embryonic day 10.5, when the first events in intestinal atresia formation are known to occur. (Mus musculus) PubMed
479.
We show that ectopic expression of WIP1 cooperates with SHH to enhance formation of medulloblastomas (Mus musculus) PubMed
480.
Sonic hedgehog from the zone of polarizing activity drives myogenesis specifically within the ventral muscle mass (Mus musculus) PubMed
481.
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. (Mus musculus) PubMed
482.
Studies suggest that altered subcellular localization of the transducer Smoothened, which functions in both the canonical and noncanonical pathways, is responsible for eliciting distinct Hedgehog (Hh) outputs. (Mus musculus) PubMed
483.
Data indicate that smoothened (Smo) mutants unable to localize to the primary cilium preferentially mediate Hedgehog (Hh) chemotaxis. . (Mus musculus) PubMed
484.
In type 1 diabetic mice the myocardial Shh pathway is impaired and the impaired Shh pathway contributes to cardiac dysfunction. (Mus musculus) PubMed
485.
Shh signaling functions as a protective signaling in the progression of acute pancreatitis. (Mus musculus) PubMed
486.
Shh signalling is required but the molecular network controlling cranial base development is distinct from that in the trunk (Mus musculus) PubMed
487.
Shh signalling is required but the molecular network controlling cranial base development is distinct from that in the trunk (Mus musculus) PubMed
488.
PN1 regulates Hh signaling by decreasing protein levels of the Hh ligand Sonic (SHH) and its downstream effectors. (Mus musculus) PubMed
489.
Shh signaling plays an essential role in a cell culture model of amyotrophic lateral sclerosis. (Mus musculus) PubMed
490.
The results of this study suooprt a model where Shh acts as a bifunctional guidance cue, attracting commissural axons toward the floorplate and then repelling them anteriorly along the AP axis. (Mus musculus) PubMed
491.
results suggested that Hh-responsive mesenchymal Bmp signaling maintains the population of peri-cloacal mesenchyme cells, which is essential for the development of the ureter and the upper urinary tract (Mus musculus) PubMed
492.
the matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis (Mus musculus) PubMed
493.
identified and characterized cis-regulatory modules of genes operating downstream of graded Shh signaling and bifunctional Gli proteins in neural patterning (Mus musculus) PubMed
494.
Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling (Mus musculus) PubMed
495.
Sonic hedgehog induces autophagy of vascular smooth muscle cells involving AKT activation, suggesting a role of autophagy in Shh-induced cellular responses. (Mus musculus) PubMed
496.
Hh signaling modulates myofibroblasts' metabolism to generate fuels for neighboring malignant hepatocytes. (Mus musculus) PubMed
497.
Interferon gamma and sonic hedgehog signaling are required to dysregulate murine neural stem/precursor cells (Mus musculus) PubMed
498.
Fgfr2 loss-of-function in the ectoderm caused derepression of Shh, revealing a role for FGF in Shh regulation in the hair follicle. (Mus musculus) PubMed
499.
Hh signaling in the mouse mammary gland through the generation of transgenic mice that express Sonic Hedgehog under the control of the mammary-specific WAP promoter. (Mus musculus) PubMed
500.
first in vivo evidence for Shh shedding and subsequent solubilization of N-terminal-truncated proteins (Mus musculus) PubMed
501.
we bring arguments supporting the view that Sulf1 controls the level of Sonic Hedgehog (Shh) signaling activity In the developing ventral spinal cord (Mus musculus) PubMed
502.
Shh signals transduced by the primary cilium prevented the aggregation of medial ganglionic eminence (MGE) cells in the cortical tangential migratory streams and helped MGE cells to leave tangential streams and to re-orient toward the cortical plate. (Mus musculus) PubMed
503.
Disp and Scube cooperate to dramatically enhance the secretion and solubility of the cholesterol-modified Hh ligand. (Mus musculus) PubMed
Sought to identify the role of Shh as regulator of gastric epithelial regeneration during wound healing using a mouse model expressing a parietal cell-specific, tamoxifen-inducible deletion of Shh (HKCre(ERT2);Shh(flox/flox) or PC-iShhKO) was developed. (Mus musculus) PubMed
506.
Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. (Mus musculus) PubMed
507.
Sonic hedgehog and brain-derived neurotrophic factor can collaborate in modulating synaptic plasticity, after removal of lumbar motoneurons by a mechanism involving both pre- and post-synaptic processes. (Mus musculus) PubMed
508.
Protein kinase A activation inhibits oncogenic Sonic hedgehog signalling and suppresses basal cell carcinoma of the skin. (Mus musculus) PubMed
509.
We propose that Ift88 and primary cilia regulate expression of Sfrp5 and Wnt signaling pathways in growth plate via regulation of hedgehog signaling. (Mus musculus) PubMed
510.
our findings identify Shh as a necessary factor playing a positive role during demyelination (Mus musculus) PubMed
511.
This study identifies Has2 as a novel downstream target of Shh signaling required for joint patterning and chondrogenesis. (Mus musculus) PubMed
512.
Sox2 contributes to Nkx2.1 expression in early mouse development, thus participating in the region-specific activation of Shh, thereby mediating ventral telencephalic patterning induction. (Mus musculus) PubMed
513.
Smo translocation to the cilium was normal in Evc2-deficient chondrocytes following Hh activation with the Smo-agonist SAG (Mus musculus) PubMed
514.
A crucial late embryonic role for Shh(Floor Plate) in regulating the specification and differentiation of glial and epithelial cells in the mouse spinal cord. (Mus musculus) PubMed
515.
Hh-Gli activators alter the function of BMP to specify perichondrial cells into osteoblasts (Mus musculus) PubMed
516.
Both activator and repressor Shh activities operate on distinct subsets of cells during epaxial myotomal maturation. (Mus musculus) PubMed
517.
Shh expression in the notochord is sufficient for pattering the entire vertebral column. (Mus musculus) PubMed
518.
Shh inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm by committing mesendodermal lineages (Mus musculus) PubMed
519.
single-cell real-time imaging to delineate the cellular mechanisms for how signalling proteins, such as sonic hedgehog (SHH), that possess membrane-bound covalent lipid modifications traverse long distances within the vertebrate limb bud in vivo (Mus musculus) PubMed
520.
HoxA and HoxD genes are required for proper AER-FGFs expression, independently of their function in controlling Shh expression (Mus musculus) PubMed
521.
Shh signalling promoted cellular condensation but not chondrogenic differentiation and also induced ATP oscillations. Blockage of Shh signalling prevented both ATP oscillations and prechondrogenic condensation. (Mus musculus) PubMed
522.
formation of the neurohypophysis requires Tbx3 and Tbx2 to sequester the SRY box-containing transcription factor Sox2 away from a Shh forebrain enhancer (SBE2) (Mus musculus) PubMed
523.
Hh signaling can regulate lung stromal cell function in two critical scenarios: normal development in postnatal lung and lung fibrosis in adult lung. (Mus musculus) PubMed
524.
Sonic hedgehog signalling plays an important role in vertebrate development including ventral body wall formation. (Mus musculus) PubMed
525.
Sonic Hedgehog patterns the anterioposterior limb primarily through the inhibition of Gli3 repressor formation. (Mus musculus) PubMed
526.
Shh stimulates early osteoblast differentiation mainly through up-regulation of the expression of Osx in osteoblastic MC3T3-E1 cells (Mus musculus) PubMed
527.
Double inhibition of NODAL and SHH pathways from the onset of gastrulation promotes holoprosencephaly. (Mus musculus) PubMed
528.
Data indicate that reduced numbers of steroidogenic factor 1-positive (SF1(+)) progenitor cells and increased fetal Leydig cells (FLCs), and increased hedgehog (Hh) activation led to decreased adult Leydig cells (ALCs) populations. (Mus musculus) PubMed
529.
The mechanism of proangiogenic activity of SHH is linked to endothelial progenitor cell mobilization (Mus musculus) PubMed
530.
in primary lung fibroblast cultures, Shh signaled exclusively through a noncanonical pathway involving generation of Rac1-GTP, whereas both the canonical and noncanonical pathways were used by the Mlg neonatal lung fibroblast cell line (Mus musculus) PubMed
531.
Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells. (Mus musculus) PubMed
532.
Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis. (Mus musculus) PubMed
533.
Derivation of lung mesenchymal lineages from the fetal mesothelium requires hedgehog signaling for mesothelial cell entry. (Mus musculus) PubMed
534.
The antagonistic effects of Sonic hedgehog and Wnt signaling critically regulate the development of dopaminergic progenitors and dopaminergic neurons. (Mus musculus) PubMed
535.
Hedgehog signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms. (Mus musculus) PubMed
536.
we propose for the first time that Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of SHH-mediated tumor angiogenesis. (Mus musculus) PubMed
537.
Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. (Mus musculus) PubMed
538.
new roles for miR-146a that established novel cross-talk between NOD2-SHH signaling during gut inflammation. (Mus musculus) PubMed
539.
These studies tested the hypothesis that Shh secreted from the acid-secreting parietal cell is a fundamental circulating factor that drives gastric repair. (Mus musculus) PubMed
540.
Point mutations in the Shh limb enhancer lead to similar anterior limb defects, highlighting the importance of Shh repression for proper patterning of the vertebrate limb. (Mus musculus) PubMed
541.
Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. (Mus musculus) PubMed
542.
Shh binds to HSPG co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation. (Mus musculus) PubMed
543.
a model where SHH signals to multiple stromal stem cells, which are largely unipotent in vivo. (Mus musculus) PubMed
544.
Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma. (Mus musculus) PubMed
545.
The results of this study suggested that Sonic hedgehog could collaborate in modulating synaptic plasticity in spinal cord injury. (Mus musculus) PubMed
546.
PACAP blocks canonical Shh signaling by a mechanism that involves activation of protein kinase A (PKA) and inhibition of the translocation of the Shh-dependent transcription factor Gli2 into the primary cilium. (Mus musculus) PubMed
547.
midline-derived Shh has a role in local tissue morphogenesis and differentiation in mice (Mus musculus) PubMed
Shh signal disruption is not the critical mechanism by which loss of Fgfr2IIIb function results in atresia formation. (Mus musculus) PubMed
550.
Shh and BMP7, which are from the anterior and posterior hypothalamic ventral midline respectively, together repel hypothalamic axons towards the medial ventral midline. (Mus musculus) PubMed
551.
in endometrial stromal cells, KLF9 provides coincident regulation of Notch, Hh, and steroid receptor signaling pathways, which when deregulated, underlie establishment and/or progression of endometriosis (Mus musculus) PubMed
552.
altered SHH signaling contributes to the etiology and pathogenesis of cleft lip through antagonistic interactions with other gene regulatory networks, including the canonical WNT and p63/IRF6 signaling pathways (Mus musculus) PubMed
553.
Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels (Mus musculus) PubMed
554.
Skeletal elements can be restored in Irx3/5 null mice when Shh signaling is diminished, indicating that Shh negatively regulates their formation after initiation. (Mus musculus) PubMed
555.
Our findings illustrate that limb development requires a sweet spot in the level and timing of pathway activation that allows for the Shh-dependent expansion of posterior progenitors without interfering with early prepatterning functions of Gli3/Gli3R. (Mus musculus) PubMed
556.
Our findings illustrate that limb development requires a sweet spot in the level and timing of pathway activation that allows for the Shh-dependent expansion of posterior progenitors without interfering with early prepatterning functions of Gli3/Gli3R. (Mus musculus) PubMed
557.
Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. (Mus musculus) PubMed
558.
conditional loss of Shh in limb buds lacking GATA6 prevents development of hindlimb polydactyly in these compound mutant embryos. (Mus musculus) PubMed
559.
Endodermal Shh and mesenchymal Foxf1 genes expression were preserved around the hindgut cystic malformation. (Mus musculus) PubMed
560.
survival analysis and immunohistochemistry identified CDA, EDIL3, ITGB4, PLAUR and SPOCK1 as SHH-dependent stromal factors that are associated with poor prognosis in PDAC (Mus musculus) PubMed
561.
Canonical Wnt-, Hh-, and Fgfr1/Fgfr2-signalling are dispensable for epicardial development, but Pdgfra-signalling is crucial for the differentiation of cardiac fibroblasts from epicardium-derived cells. (Mus musculus) PubMed
562.
study shows evolutionary alteration of a Ptch1 cis-regulatory module, which no longer responds to graded SHH signalling during bovine handplate development (Mus musculus) PubMed
563.
Shh, secreted from mesenchymal stem cells, provides a proliferative stimulus for the gastric epithelium that is associated with tumor development (Mus musculus) PubMed
564.
an essential role for both primary cilia assembly and disassembly in the control of Hh signaling and early differentiation in muscle cells. (Mus musculus) PubMed
565.
In mouse embryonic endodermal tissues, the seamless expression of Shh is achieved by a patchwork of multiple enhancers with different rates of evolution. (Mus musculus) PubMed
566.
Hh signaling regulates the proliferation of MF-HSCs irrespective of the action of miRNA-29, eventually contributing hepatic fibrosis, when the NF-kappaB pathway is disrupted. (Mus musculus) PubMed
567.
Quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. (Mus musculus) PubMed
568.
results reveal BET proteins as critical regulators of Hedgehog pathway transcriptional output and nominate BET bromodomain inhibitors as a strategy for treating Hedgehog-driven tumors (Mus musculus) PubMed
569.
SHH can replace the need for innervation to drive the entire program of taste bud differentiation (Mus musculus) PubMed
570.
Our results indicate that Abp1 negatively regulates BCR signaling by coupling actin remodeling to B-cell contraction and activation of inhibitory signaling molecules (Mus musculus) PubMed
571.
Increased SHH in the posterior Slk leg bud causes expression of anterior ectopic SHH and preaxial polydactyly. (Mus musculus) PubMed
572.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome . (Mus musculus) PubMed
573.
Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates. (Mus musculus) PubMed
574.
Suggest a novel miR-326-negative feedback loop in regulating the activity of Shh/Gli/Smo signaling. (Mus musculus) PubMed
575.
Ptch1(-/-);Ptch2(-/-) cells cannot further activate the Shh response, demonstrating that Ptch2 mediates the response to Shh in the absence of Ptch1. (Mus musculus) PubMed
576.
The teratogenic effects of prenatal ethanol exposure are exacerbated by Sonic Hedgehog or GLI2 haploinsufficiency in the mouse. (Mus musculus) PubMed
577.
through interactions with FoxA2, Arx positively regulates Shh expression in the floor plate, and Shh signaling in turn activates Nkx2.2, which suppresses Arx expression. (Mus musculus) PubMed
578.
overexpression of the Hh pathway using a plasmid encoding the human Shh gene promotes successful regeneration after injury in terms of increased number of proliferating myogenic cells and newly formed myofibers. (Mus musculus) PubMed
579.
Shh and BMP7, which are expressed in the anterior and posterior hypothalamic ventral midline respectively, together repel hypothalamic axons towards the medial ventral midline (Mus musculus) PubMed
580.
analysis of the Shh long-range regulatory domain in mouse embryo (Mus musculus) PubMed
581.
GATA transcription factors are repressors of hedgehog signaling, and NKX3.2 maintains the ability of sclerotomal cells to express SHH transcriptional targets in the presence of BMP signals by repressing the induction of Gata4/5/6 (Mus musculus) PubMed
582.
specific and potent kidney tubule-derived growth factor that promotes interstitial fibroblast proliferation and activation (Mus musculus) PubMed
583.
Sonic hedgehog secreted by neurons regulates ang-1 and ang-2 expression in neighboring fibroblasts. (Mus musculus) PubMed
584.
Mesenchymal stem cells originate from periarterial cells and are regulated by Shh secretion from an neurovascular bundle. (Mus musculus) PubMed
585.
A signaling mechanism based on FGF10 and SHH directs outgrowth of the lung bud via a ligand-receptor-based Turing mechanism and a geometry effect in the embryonic mouse. (Mus musculus) PubMed
586.
Data indicate a specific genetic requirement for Gli proteins in Hedgehog (Hh)-induced embryonal rhabdhomyosarcoma (eRMS) formation. (Mus musculus) PubMed
587.
when Shh function is altered selectively in a conditional mutant mouse strain, most populations normally generated in the medial basal plate of r1 are completely absent (Mus musculus) PubMed
588.
These data suggest that embelin can inhibit pancreatic cancer growth, angiogenesis and metastasis by suppressing Akt and Shh pathways, and can be developed for the treatment and/or prevention of pancreatic cancer. (Mus musculus) PubMed
589.
cEbf1 gene is considered as a medial sclerotome marker, downstream to and regulated by the notochord derived Shh, which may be functionally involved in somitogenesis (Mus musculus) PubMed
590.
Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo (Mus musculus) PubMed
591.
SHH promotes the survival of neural crest cells by limiting apoptosis induced by the dependence receptor CDON during branchial arch development. (Mus musculus) PubMed
592.
A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. (Mus musculus) PubMed
593.
When Shh is presented as a point source, enteric axons turn away from it in a Gas1-dependent manner. (Mus musculus) PubMed
594.
Data indicate that the bromodomain protein inhibitor I-BET151 attenuates Hedgehog signaling downstream of Smoothened protein. (Mus musculus) PubMed
595.
Results show that SHH secreted by astrocytes drives the activation and proliferation of astrocytes and microglia in response to neurodegeneration-induced lesions (Mus musculus) PubMed
596.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh as early as E18.5, suggesting a regulation of glial development by Shh (Mus musculus) PubMed
597.
Suggest that Cdo is required for the full Shh signaling activation to induce efficient dopaminergic neuron neurogenesis. (Mus musculus) PubMed
598.
These studies highlight the importance of p63 in maintaining the self-renewal potential of mammary cancer stem cells via a positive modulation of the Hh signaling pathway. (Mus musculus) PubMed
599.
Shh signaling pathway induces myopic development by activating MMP-2 in guinea pigs (Mus musculus) PubMed
600.
Sonic Hedgehog has a conserved role in tonotopic organization of the avian basilar papilla and mammalian cochlea (Mus musculus) PubMed
601.
Sonic Hedgehog has a conserved role in tonotopic organization of the avian basilar papilla and mammalian cochlea (Mus musculus) PubMed
602.
Shh+ cells are not stem cells, but are post-mitotic, immediate precursors of taste cells. Shh+ cells differentiate into each of the three taste cell types, and the choice of a specific taste cell fate is regulated to maintain the proper ratio within buds. (Mus musculus) PubMed
603.
A novel mechanism for Il1b mediated disruption of the blood brain barrier via downregulation of SHH. (Mus musculus) PubMed
604.
The lack of detrusor smooth muscle development observed in megabladder (mgb-deficient) mice is associated with bladder-specific temporospatial changes in Sonic Hedgehog signaling coupled with a lack of Myocardin expression. [mgb protein, mouse] (Mus musculus) PubMed
605.
Data indicate that hedgehog (Hh) signaling activated the expression of insulin-like growth factor 2 (Igf2) that during osteoblast differentiation. (Mus musculus) PubMed
606.
Results show that Shh interactions with proteoglycan co-receptors function at multiple locations to regulate neurogenesis and precise olfactory connectivity, thereby promoting functional neuronal circuitry (Mus musculus) PubMed
607.
Helicobacter pylori induces Shh expression from the parietal cells, a response mediated via activation of NFkappaB signaling. (Mus musculus) PubMed
608.
Shh and transforming growth factor beta signaling cooperate to promote Ptch1-associated cataract development by activating EMT (Mus musculus) PubMed
609.
These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery. (Mus musculus) PubMed
610.
These data identify Notch signalling as a novel modulator of Shh signalling that acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery. (Mus musculus) PubMed
611.
Studies indicate the importance of survivin in Sonic hedgehog (SHH)-driven medulloblastoma (MB). (Mus musculus) PubMed
612.
anterior and superficial Shh expression domain reflects the rudimentary tooth development suppressed during evolution. The posterior Shh expression region, appearing at ED13.5, correlates with the prospective upper functional incisor in wild-type mice. (Mus musculus) PubMed
613.
Data show that the Hedgehog (Hh) pathway activation by either a ligand or genetic loss of the negatively acting Hh receptor Patched-1 (Ptch) reduced the affinity and frequency of signaling protein Smoothened (Smo) binding at the base. (Mus musculus) PubMed
614.
The Shh induced dephosphorylation of glycogen synthase kinase 3beta through the Smoothened receptor and increased the phosphorylation of Smad1 and Smad2/3 in mESCs. (Mus musculus) PubMed
615.
immunohistochemical analysis reveals earlier induction of beta-catenin and Sonic hedgehog (Shh) in hair follicles of the FGFs-treated group. (Mus musculus) PubMed
616.
SHH signaling pathway was activated in the development process of LPS-induced ALI, and up-regulated expressions of SHH signaling pathway associated molecules could relieve lung injury and involve repair of the injured lung tissues. (Mus musculus) PubMed
617.
An intrinsic cell cycle clock in polarizing region cells of the chick limb bud times the duration of Sonic hedgehog (Shh) expression, which encodes the morphogen specifying digit pattern across the antero-posterior axis (thumb to little finger). (Mus musculus) PubMed
618.
Data show that the Hh (Hedgehog) signalling pathway mediates chemoresistance of BCSCs (breast cancer stem cells) and contributes to the outcome in breast cancer patients. (Mus musculus) PubMed
619.
results demonstrate that epithelial-mesenchymal interactions coordinated by hedgehog actively maintain postnatal tissue homeostasis, and deregulation of hedgehog during injury leads to aberrant repair and regeneration in the lung (Mus musculus) PubMed
620.
SHH produced by the pharyngeal arch 1 epithelium is necessary for the survival of post-migratory cranial neural crest cells (Mus musculus) PubMed
621.
increased expression in cell bodies of cutaneous sensory nerves of dorsal root ganglia as compared with skin epithelia (Mus musculus) PubMed
622.
Shh activation induces a local switch of epigenetic cofactors from the H3K27 methyltransferase polycomb repressive complex 2 to an H3K27me3 demethylase Jmjd3/Kdm6b-centred coactivator complex. (Mus musculus) PubMed
623.
Integration of shallow gradients of Shh and Netrin-1 synergistically guides commissural axons in the growing spinal cord. (Mus musculus) PubMed
624.
in embryos with lower Spry2;Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud (Mus musculus) PubMed
625.
The expression of GRP78 and Bcl-2 was significantly higher in astrocytes pretreated with recombinant Shh. These findings suggest that the expression of Shh may inhibit cell death by activating Bcl-2 through a GRP78-dependent pathway. (Mus musculus) PubMed
626.
An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation. (Mus musculus) PubMed
627.
These findings confirm that fate determination of cortical interneurons subgroups is crucially influenced by Shh signaling, and provide a system for the further study of interneuron fate and function. (Mus musculus) PubMed
628.
novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling (Mus musculus) PubMed
629.
Shh is intensely and extensively expressed in the supra-IEE and stellate reticulum at the center of enamel organ. Shh is intensely expressed in the IEE and supra-IEE in the enamel-related epithelium in mice. (Mus musculus) PubMed
630.
SHH determines the formation of spinal cord during the development of chicken embryo. (Mus musculus) PubMed
631.
we observed a glial reaction and an activity-dependent modification of Shh, Noggin, and Numb proteins. we found that Shh and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 and Numb (Mus musculus) PubMed
632.
SHH may affect alveolar bone healing by interacting with CGRP-positive sensory neurons and thus regulate the socket's healing process after tooth extraction. (Mus musculus) PubMed
633.
Data show that the ketogenic diet does not affect growth of Ptch1+/-Trp53-/- Hedgehog (HH) pathway medulloblastoma. (Mus musculus) PubMed
634.
novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression (Mus musculus) PubMed
635.
These results identify for the first time a crucial role of primary cilia in the induction of mDA progenitors, define a narrow time window in which Shh-mediated signaling is dependent upon normal primary cilia function. (Mus musculus) PubMed
636.
Epidermal Shh stimulates proliferation of the papillary fibroblast lineage. (Mus musculus) PubMed
637.
The authors found that specific inhibition of Shh from hair follicles or from epithelial sources in general hindered development of Shh-responding dentate stem cells and that platelets contain epithelial Shh and provide Shh to the perinatal dentate gyrus. (Mus musculus) PubMed
638.
Leptin upregulated Hedgehog signaling pathway in the process of adipocyte differentiation. (Mus musculus) PubMed
639.
Sufu deletion early in embryogenesis resulted in unstable Gli2 and Gli3 activity, leading to the ectopic activation of Shh signaling. (Mus musculus) PubMed
640.
Results suggest that amygdala neurogenesis and Shh signaling are involved in the extinction of fear memory (Mus musculus) PubMed
641.
Loss of N-myc significantly impairs the Sonic hedgehog signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2. (Mus musculus) PubMed
642.
Specific inactivation of Srg3 a core subunit of the remodeling complex, in developing limb buds hampered the transcriptional upregulation of Shh/Gli target genes, including the Shh receptor Ptch1 and its downstream effector Gli1 in the posterior limb bud (Mus musculus) PubMed
643.
NANOG binds to GLI1 and GLI3 proteins and represses Hedgehog-mediated transcription. (Mus musculus) PubMed
644.
Data show that the proliferation of sustained expression of Notch1-induced choroid plexus (CP) tumours relies on Sonic Hedgehog (Shh) from the tumour microenvironment through their primary cilium. (Mus musculus) PubMed
645.
We proposed that LKB1 regulates cerebellar development by controlling GCPs proliferation through Shh signalling during cerebellar development. (Mus musculus) PubMed
646.
Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis. Hedgehog's effects on apoptosis can occur independent of glucocorticoid stimulation. (Mus musculus) PubMed
647.
The effect of fibronectin on the neurite outgrowth from embryoid bodies in neurodifferentiated embryonal carcinoma P19 cells was studied. (Mus musculus) PubMed
648.
Report exposes a novel role for Shh in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2. (Mus musculus) PubMed
649.
When the Shh signaling inhibitor jervine was added to the culture medium for 24-96 h, the formation of lateral lingual swellings and subsequent epithelial invagination into the mesenchyme were impaired markedly, leading to a hypoplastic tongue (Mus musculus) PubMed
650.
Activating the Shh signaling rescues endothelial progenitor cell dysfunction and promotes diabetic neovascularization. (Mus musculus) PubMed
651.
Chronic up-regulation of Shh had minimal effect on craniofacial shape and did not correct facial abnormalities in Ts65Dn;Ptch(+/-) mice. (Mus musculus) PubMed
652.
these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt pathway, and inhibition of Smad2/3 signaling and Shh pathways. (Mus musculus) PubMed
653.
Shh promotes neurite outgrowth in primary cortical neurons at least partially through modulating BDNF expression. (Mus musculus) PubMed
654.
Results indicate that an aged-related delay of fracture healing may contribute to the unbalanced bone formation and resorption, regulated by hedgehog signaling. (Mus musculus) PubMed
655.
Shh stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. (Mus musculus) PubMed
656.
found that the SHH expression promoted the transition from hepatocellular adenoma to hepatocellular carcinoma (Mus musculus) PubMed
657.
Hip suppresses Shh signaling through sequestering Shh (Mus musculus) PubMed
658.
Lipoloysaccharide-induced chorioamnionitis leads to changes in Shh signaling in the fetal lung. (Mus musculus) PubMed
659.
Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh), and bone morphogenetic protein-2 (Bmp2) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol. (Mus musculus) PubMed
660.
undertook a high content screen with compounds in preclinical or clinical development and identified ten small molecules that prevent constitutive active mutant SmoM2 transport into PC for subsequent Hh pathway activation (Mus musculus) PubMed
661.
Wnt, Eda, and Shh have roles in touch dome Merkel cell development (Mus musculus) PubMed
662.
PRC2 loss expands the field of epidermal cells competent to differentiate into Merkel cells through the upregulation of key Merkel-differentiation genes, and requires SHH (Mus musculus) PubMed
663.
These results indicate that the modulatory effects of SHH on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 expression but not Fgf10 expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis. (Mus musculus) PubMed
664.
These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway. (Mus musculus) PubMed
665.
Shh acts as an endogenous mediator of mechanical stimuli on bone marrow stromal cells. Shh expression is regulated by DNA methylation. (Mus musculus) PubMed
666.
propose a model in which positive and negative transcriptional regulatory networks accumulate their functions in the intersection area of their expression regions to provide a restricted spot for the ZPA (zone of polarizing activity), the source of morphogen, Shh. (Mus musculus) PubMed
667.
hair follicle transit-amplifying cells (HF-TACs) play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog (Mus musculus) PubMed
668.
these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation. (Mus musculus) PubMed
669.
Activated microglia are major cell type for SHH expression in vivo and in vitro. (Mus musculus) PubMed
670.
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing. (Mus musculus) PubMed
671.
cAMP dependent protein kinase A (PKA) is a key intracellular factor mediating SHH signaling through regulation of GLI3 processing. (Mus musculus) PubMed
672.
Tbx2 and Tbx3 function downstream of Shh to maintain pro-proliferative mesenchymal Wnt signaling. (Mus musculus) PubMed
673.
Sufu is upregulated in active Shh responding tissues and accompanies Gli activators translocating into and Gli repressors out of the nucleus. (Mus musculus) PubMed
674.
Shh and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh away from the pathways that promote its secretion. (Mus musculus) PubMed
Our results suggest that Shh contributes to the development of epilepsy and suppression of its signaling prevents the development of the disease. Thus, Shh can act as a modulator of neuronal activity, rapidly regulating glutamate levels and promoting epilepsy. (Mus musculus) PubMed
677.
We show that retinoic acid promotes, whereas SHH, acting strictly within the lingual epithelium, inhibits taste placode and lingual gland formation by thwarting RA activity. (Mus musculus) PubMed
678.
Both the number of lung CD31-CD45-Sca-1+ cells and the expression levels of the Shh signaling pathway were downregulated in the lung tissues of mice with pulmonary emphysema. These cells and Shh signaling pathway are reactivated during acute adenovirus infection. (Mus musculus) PubMed
679.
sonic hedgehog signaling activity influences clonal spatial distribution of thalamic neurons. (Mus musculus) PubMed
680.
High SHH expression is associated with Medulloblastoma. (Mus musculus) PubMed
681.
This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB. (Mus musculus) PubMed
682.
A model in which SHH signaling plays both positive and negative roles in patterning and organogenesis of the thymus and parathyroids. (Mus musculus) PubMed
683.
Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1, and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 function. (Mus musculus) PubMed
684.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med... (Mus musculus) PubMed
685.
direct targeting of Foxf2 by Shh signaling drives cranial neural crest cell mesenchyme proliferation during upper lip morphogenesis, and disruption of this sequence results in cleft lip. (Mus musculus) PubMed
686.
Data indicate odd-skipped related protein 1 (Osr1) as a mediator of Hedgehog (HH) signaling during foregut organogenesis. (Mus musculus) PubMed
687.
Results indicate that the transcription factor Gli3 (Gli3)-mutant fetal liver (FL) had increased sonic hedgehog (Shh) signaling resulting in decreased B cell development. (Mus musculus) PubMed
688.
GPC6 stimulates Hh signaling by binding to Hh and Ptc1 at the cilium and increasing the interaction of the receptor and ligand to promote the growth of developing long bones. (Mus musculus) PubMed
689.
Shh is in part responsible for the dependence of taste cell renewal on gustatory innervation, neurotrophic support of taste buds likely involves a complex set of factors. (Mus musculus) PubMed
690.
Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma (Mus musculus) PubMed
691.
conditional deletion of Shh in the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest of (Rathke's pouch) RP development, with lack of Lhx3/Lhx4 expression in RP epithelium. (Mus musculus) PubMed
692.
provide compelling evidence that epidermal YAP and Hedgehog/GLI2 signalling undergo positive regulatory interactions in the control of normal epidermal homeostasis and in basal cell carcinoma (BCC) development, which in the large majority of cases is caused by aberrant Hedgehog signalling activity (Mus musculus) PubMed
693.
reactivating SHH signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH signaling activity did not appear to be caused by decreased Shh expression or protein stability; instead, biologically active form of SHH proteins were reduced in both the Ext1 mutant epithelium and surrounding wild type mesenchymal cells. (Mus musculus) PubMed
694.
Embryonal tumors with multilayered rosettes (ETMRs) are characterized by a parallel activation of Shh and Wnt signaling. Co-activation of these pathways in mouse neural precursors is sufficient to induce ETMR-like tumors in vivo that resemble their human counterparts on the basis of histology and global gene-expression analyses, and that point to apical radial glia cells as the possible tumor cell of origin. (Mus musculus) PubMed
695.
The authors find that cholesterol, an important component of the cell membrane, directly binds to Smoothened and changes its shape so that it can activate Hedgehog signaling components inside cells. (Mus musculus) PubMed
696.
neuroectodermal Shh expression, dorsal/ventral patterning, and amount of proliferation in the ventral neuroectoderm was not changed in Wnt1-Cre;Kif3a(fl/fl) mutants; however, tissue polarity and directional cell division were disrupted. (Mus musculus) PubMed
697.
Hh orchestrates the balance between quiescent and activated NSCs, with important implications for understanding adult neurogenesis under normal homeostatic conditions or during injury. (Mus musculus) PubMed
698.
Results report the identification of a novel long-range enhancer for Shh-Shh-brain-enhancer-6 (SBE6)-that is located 100 kb upstream of Shh and that is required for the proper induction of Shh expression during this differentiation program. (Mus musculus) PubMed
699.
These results support a model whereby mutations in Cdon and prenatal ethanol exposure increase Septo-optic dysplasia risk through spatiotemporal perturbations in Shh signaling activity. (Mus musculus) PubMed
700.
These studies reveal a postnatal cell population with transient Shh signaling that contributes to oligodendrogenesis during corpus callosum myelination, and gives rise to cells that continue to proliferate in adulthood and contribute to corpus callosum remyelination (Mus musculus) PubMed
701.
SHH can promote cell growth and cell osteoblastic/cementoblastic differentiation via BMP pathway (Mus musculus) PubMed
702.
smaller mvShh conjugates resulted in faster wound resolution compared to the unconjugated Shh. This study is the first to show how the wound healing efficacy of multivalent protein-polymer conjugates is sensitive to the polymer MW, and our findings suggest that this parameter could be used to enhance the efficacy of growth factor conjugates. (Mus musculus) PubMed
703.
The Function of SDF-1-CXCR4 Axis in SP Cells-Mediated Protective Role for Renal Ischemia/Reperfusion Injury by SHH/GLI1-ABCG2 Pathway (Mus musculus) PubMed
704.
Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation (Mus musculus) PubMed
705.
The present study shows a new role for Maml1 as a component of Shh signaling, which plays a crucial role in both development and tumorigenesis. (Mus musculus) PubMed
706.
Gli3 activity in mouse thymic epithelial cells (TECs) promotes positive selection and differentiation from CD4(+) CD8(+) to CD4(+) CD8(-) single-positive (SP4) cells in the fetal thymus and Gli3 represses Shh constitutive deletion of Gli3, and conditional deletion of Gli3 from TECs, reduced differentiation to SP4, whereas conditional deletion of Gli3 from thymocytes did not (Mus musculus) PubMed
707.
by acting upstream of Shh signaling pathway, Barhl2 plays a crucial role in patterning the progenitor domains and establishing the positional identities of progenitor cells in the diencephalon. (Mus musculus) PubMed
708.
SHH-dependent activation of WNT signaling supports regeneration of the cortex following long-term glucocorticoid treatment. (Mus musculus) PubMed
709.
Shh signaling requires the coordinated activity of Sulf1 and Sulf2 in order to reach that threshold in the mouse ventral spinal cord (Mus musculus) PubMed
710.
Importantly, Scube2 uncouples processing of Shh peptides from their lipid-mediated juxtamembrane positioning, and thereby explains the long-standing conundrum that N-terminally unlipidated Shh shows patterning activity in Scube2-expressing vertebrates (Mus musculus) PubMed
711.
results indicate for the first time a possible mechanism involved in the crosstalk between fibroblasts and osteoblasts, as it was possible to observe trophic factors released by fibroblasts interfering decisively in osteoblast metabolism in a Shh-independent manner. (Mus musculus) PubMed
712.
ESP of fifth-stage larval Angiostrongylus cantonensis stimulates astrocyte activation and IL-1beta and IL-6 production through NF-kappaB and the Shh signaling pathway. (Mus musculus) PubMed
713.
The authors report here that Sonic Hedgehog (Shh)-Smoothened signaling downregulates Shisa2, which inhibits the glycosylation and cell surface presentation of Frizzled3 in rodent commissural axon growth cones. (Mus musculus) PubMed
714.
SHH signaling regulates the direction of cerebellar granule cells division. (Mus musculus) PubMed
715.
the knockdown of Ihh suppressed osteoblast growth and differentiation via a mechanism which may be associated with the TGF-beta/Smad and OPG/RANKL signaling pathways. (Mus musculus) PubMed
716.
Epithelial-mesenchymal transition programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. (Mus musculus) PubMed
717.
These data suggest a potential novel mechanism in which alterations in SHH variance during evolution may have driven changes in limb patterning and digit length. (Mus musculus) PubMed
718.
Here by inducing expression of constitutively active Smoothened (SmoM2) or Gli2 (DeltaNGli2) in the adipocyte lineage of postnatal mice, the authors show that targeted activation of Hedgehog signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tolerance and insulin sensitivity. (Mus musculus) PubMed
719.
Data show that Sonic hedgehog (Shh), which encodes a secreted protein signal, is expressed in the sensory neurons, and that experimental ablation of neuronal Shh expression causes loss of taste receptor cells (TRCs). (Mus musculus) PubMed
720.
In the mutant Hammer toe (Hm) genome, a 150-kb noncoding DNA fragment from chromosome 14 is inserted into the region upstream of the Sonic hedgehog (Shh) promoter in chromosome 5. Two different regions are necessary for the syndactyly phenotype of Hm. (Mus musculus) PubMed
721.
Identify SMO-dependent Shh signalling as a specific process for the activation of adventitial fibroblasts and the subsequent proliferation of smooth muscle cells and neointima formation. (Mus musculus) PubMed
722.
High SHH expression is associated with medulloblastoma formation. (Mus musculus) PubMed
723.
SOX2 functions downstream of HH signaling to regulate lingual epithelium homeostasis. (Mus musculus) PubMed
724.
data illustrate that persistent Hh signaling in the palatal epithelium contributes to the etiology and pathogenesis of submucous cleft palate through its interaction with a p63/Irf6-dependent biological regulatory loop and through a p63-induced cell adhesion network. (Mus musculus) PubMed
725.
The results of this study indicated that Shh, Sfrp1, and Wnt5a collaborate to direct the pathfinding of descending 5-HT axons in the brainstem. (Mus musculus) PubMed
726.
Results suggest distinct functions of tuberous sclerosis complex 1 protein (Tsc1) and tuberous sclerosis complex 2 protein (Tsc2) in cellular signaling as the two genes affect ciliary length control and sonic hedgehog protein signaling via different mechanisms. (Mus musculus) PubMed
727.
show that eliminating mouse MACS1 causes severe defects in laryngeal development, indicating that MACS1-directed Shh signalling is indispensable for respiratory organogenesis (Mus musculus) PubMed
728.
quiescent dental stem cells are regulated by Shh signaling. (Mus musculus) PubMed
729.
Shh signal activation in Wnt active cells promotes the dermal papilla fate in scarring wounds. (Mus musculus) PubMed
730.
results indicate that SHH signaling is critically important in the regulation of hematopoietic stem/progenitor cell activation and reprogramming during the granulopoietic response to serious bacterial infection. (Mus musculus) PubMed
731.
loss of Shh at the late-gestational stage leads to megaesophagus with reduced proliferation and a muscle development disorder in mice. (Mus musculus) PubMed
732.
Shh is capable of activating the Hh pathway via Smoothened, independently of Patched1/2. (Mus musculus) PubMed
733.
This study provides further evidence of chondrogenic induction of bone marrow-derived mesenchymal stem cells in vitro via IHH and SHH gene delivery. (Mus musculus) PubMed
734.
The genomic regulatory regions controlling production of SHH in the nervous system contribute to facial cartilage morphogenesis, which might be a mechanism responsible for the adaptive evolution of animal faces and snouts. (Mus musculus) PubMed
735.
Shh components are also active adjacent to human congenital nevi. Mechanistically, this exacerbation of nevogenesis is driven via the release of the melanocyte mitogen endothelin-1 from keratinocytes. We then suppressed nevus development in mice using Shh and endothelin antagonists (Mus musculus) PubMed
736.
the effects of recombinant Shh and the distribution of Gli-1 during in vitro and in situ embryonic chick skeletal muscle differentiation at later stages of development. (Mus musculus) PubMed
737.
The results revealed that the copy number gain type of SHH-CNV exhibited significantly better chest depth in 24 months old Qinchuan cattle, and better body weight, body length, and chest girth in 18 months old Nanyang cattle, whereas the normal copy number had superior chest girth and body weight in adult Jinnan cattle..this research uncovered meaningful effects of SHH-CNV on gene expression and cattle phenotypic traits (Mus musculus) PubMed
738.
The results reveal a novel Shh-Foxd1-Cdkn1c regulatory circuit that drives the mitogenic action of Shh signaling. Forkhead box gene Foxd1 is transcriptionally regulated by canonical Shh signaling. (Mus musculus) PubMed
739.
Shh protein is produced by contralateral RGCs at the retina, transported anterogradely along the axon, and accumulated at the optic chiasm to repel ipsilateral RGCs. In vitro, contralateral RGC axons, which secrete Shh, repel ipsilateral RGCs in a Boc- and Smo-dependent manner. Knockdown of Shh in the contralateral retina causes a decrease in the proportion of ipsilateral RGCs in a non-cell-autonomous manner. (Mus musculus) PubMed
740.
Endogenous Shh does not promote ischaemia-induced angiogenesis. On the contrary, the absence of Shh leads to aberrant ischaemic tissue inflammation and a transiently increased angiogenesis. (Mus musculus) PubMed
741.
The results of this study indicated that Shh is in the right place at the right time to influence the development of GnRH neurites. (Mus musculus) PubMed
742.
The results showed that a protein called Furin activates Dispatched by splitting it at a specific point. When the break-point on Dispatch was genetically modified, Furin could no longer cleave the protein. As a consequence, Dispatched did not reach the correct location within cells to help Hedgehog move away from signal-releasing cells. (Mus musculus) PubMed
743.
We found that developing teeth from K14-CRE/Shhf/f mutant mice exhibit severe downregulation of Cyp26a1 and Cyp26c1 expression levels in the inner dental epithelium (Mus musculus) PubMed
744.
The results implicate that KLF4 plays important roles for maintaining osteoblasts in an immature state by repressing basal activation of the Hedgehog signaling. (Mus musculus) PubMed
745.
Data suggest that the sensitivity of target cells to Sonic Hedgehog (SHH) morphogens, and the consequent effects on gene expression and differentiation outcomes, can be controlled by signals from G protein-coupled receptors. (Mus musculus) PubMed
746.
Shh induces adherens junction disruption and integrin beta1-dependent F-actin formation by a mechanism involving FAK/Src and Rac1/Cdc42 signalling pathways in mESCs (Mus musculus) PubMed
747.
Our data provide evidence for a new model in which Shh signaling increases in the dorsal forebrain late in embryonic development to provide a temporally regulated mechanism that initiates the third wave of neocortical oligodendrogenesis. (Mus musculus) PubMed
748.
these results implicate Shh signaling as a regulator of mammalian heart regeneration and suggest that modulating this pathway may lead to new potential therapies for cardiovascular diseases. (Mus musculus) PubMed
749.
The results suggested a second heart field regulatory network comprising of Gata4, Gata6 and SHh-signaling for outflow tract development. (Mus musculus) PubMed
750.
on a molecular level the human and mouse HH-dependent MB are quite distinct, with human, but not mouse, tumors characterized by the presence of markers of increased oxidative phosphorylation and mitochondrial biogenesis. (Mus musculus) PubMed
751.
depletion of endogenous cholesterol also reduced Shh-induced ALP activity and Gli1 expression. Likewise, cholesterol depletion inhibited osteogenic response to Purmo, although it did not affect Gli1 induction. Taken together, our findings have demonstrated that cholesterol plays a dual role in osteoblast differentiation likely through both Hh-dependent and -independent mechanisms (Mus musculus) PubMed
Loss of Shh signaling in the neocortex reveals heterogeneous cell recovery responses from distinct oligodendrocyte populations. (Mus musculus) PubMed
754.
suppression of Shh pathway during early mid-gestation prevents ventricular overgrowth, and regulates cortical gyration and neocortical/periventricular cytoarchitecture. (Mus musculus) PubMed
755.
These data identify a critical role for Shh signaling in astrocyte-mediated modulation of neuronal activity required for sculpting synapses. (Mus musculus) PubMed
756.
SHH activity clearly declines with aging and subsequently attenuates endometrial stem cell loss and dysfunction in the aging process by suppressing the expression of SERPINB2. (Mus musculus) PubMed
757.
Observe a decreased spatial proximity between Shh and its enhancers during the differentiation of embryonic stem cells to neural progenitors. (Mus musculus) PubMed
758.
AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins. (Mus musculus) PubMed
759.
AKT stimulates the Shh activity to induce lateral motor columnar motor neurons through the stabilization of ARHGAP36 proteins. (Mus musculus) PubMed
760.
Here, the authors show that Suppressor of Fused (Sufu) controls establishment of the quiescent NSC pool during mouse dentate gyrus (DG) development by regulating Sonic Hedgehog (Shh) signaling activity. (Mus musculus) PubMed
761.
The ciliopathy gene Ftm/Rpgrip1l controls mouse forebrain patterning via region-specific modulation of Hedgehog/Gli signaling. (Mus musculus) PubMed
762.
Rack1 controls the activation of Shh signaling by regulating the ubiquitylation and stability of histone deacetylase 1 (HDAC1)/HDAC2. (Mus musculus) PubMed
763.
Using a newly described small-molecule, SSTC3, we show that CK1a activators could address a significant unmet clinical need for patients with SMO inhibitor-resistant medulloblastoma, including those harboring mutations in TRP53 (Mus musculus) PubMed
764.
An enhancer, SBE7, that regulates prechordal Shh expression has been found near a cluster of known forebrain enhancers for Shh. This enhancer directs Shh expression in the ventral midline of the forebrain and for subsequent Shh induction in the forebrain.SHH signaling mediated by the newly identified enhancer is essential for development and growth of the ventral midline of the forebrain and hypothalamus. (Mus musculus) PubMed
765.
Hedgehog signaling was decreased in HHIPL1-deficient cells.In vitro analyses revealed that HHIPL1 is a secreted protein that interacts with SHH and increases hedgehog signaling activity. (Mus musculus) PubMed
766.
findings establish an important role for Shh upregulation in preventing atopic dermatitis, by increased Gli-driven Treg cell-mediated immune suppression, paving the way for a potential new therapeutic strategy. (Mus musculus) PubMed
767.
These results uncovered a novel mechanistic association between retinoic acid-induced cleft palate with decreased Shh signaling and elevated cranial neural crest cell apoptosis. (Mus musculus) PubMed
768.
SHH activates calcium oscillations in hippocampal astrocytes. (Mus musculus) PubMed
769.
tumor-derived SHH has a role in promoting tumor-associated macrophage M2 polarization, and in a mechanism for tumor-associated macrophage-mediated immunosuppression (Mus musculus) PubMed
770.
In E10.5 embryos, bioluminescence intensity markedly increased, mostly corresponding to the high sonic hedgehog (Shh) activity of the developing midbrain and limb. (Mus musculus) PubMed
771.
This target gene classification scheme provides novel insight into several unanticipated roles for Shh, including priming the cochlear epithelium for subsequent sensory development. (Mus musculus) PubMed
772.
Using mouse embryonic stem cell-derived mosaic tissues with compartments that lack Exostosin1 and Exostosin2, or Glypican5, it has been shown that Shh accumulates around its source cells when they are surrounded by cells that have a mutated extracellular matrix. (Mus musculus) PubMed
773.
local SHH signalling has a role in tongue development (specifically, lingual tendon differentiation and intrinsic muscle patterning through signalling to cranial neural crest cells) (Mus musculus) PubMed
774.
the developmental regulation of Shh expression is remarkably robust to Topologically associating domain perturbations. (Mus musculus) PubMed
775.
Results show that hedgehog protein (Hedgehog) receptors patched 1 protein (Ptch1) and patched 2 protein (Ptch2) elicit independent responses, which enable multimodal Hedgehog signaling to simultaneously regulate epithelial stem cells (SCs) maintenance and differentiation. (Mus musculus) PubMed
776.
Results demonstrated that Shh regulated bone marrow stromal cells (BMSCs) chondrogenesis under microgravity conditions equivalent to TGF-beta, and significantly improved the early stages of the repair of cartilage and subchondral defects. (Mus musculus) PubMed
777.
The correct location of sonic hedgehog protein (SHH) expression is vital to the formation of the motor column. (Mus musculus) PubMed
778.
Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane. (Mus musculus) PubMed
779.
Sonic Hedgehog Is a Determinant of gammadelta T-Cell Differentiation in the Thymus. (Mus musculus) PubMed
780.
GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling. (Mus musculus) PubMed
781.
Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. (Mus musculus) PubMed
Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species. (Mus musculus) PubMed
784.
Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix. (Mus musculus) PubMed
785.
Electrophysiological characterization of acutely isolated spiral ganglion neurons in neonatal and mature sonic hedgehog knock-in mice. (Mus musculus) PubMed
786.
Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas. (Mus musculus) PubMed
787.
The Neocortical Progenitor Specification Program Is Established through Combined Modulation of SHH and FGF Signaling. (Mus musculus) PubMed
788.
Sonic hedgehog is a potent inducer of rat oligodendrocyte development from cortical precursors in vitro. (Rattus norvegicus) PubMed
789.
The Shh receptor Patched occurred in both the adult rat hippocampus and neural progenitor cells. Sonic hedgehog elicited a strong proliferative response in progenitors in vitro. Shh is a regulator of adult hippocampal neural stem cells. (Rattus norvegicus) PubMed
790.
Sonic hedgehog injected into rat striatum increases the levels of Patched protein in the subventricular zone (SVZ). However, proliferation and differentiation of SVZ precursor cells were not affected. (Rattus norvegicus) PubMed
791.
Significant role in establishing and maintaining penile homeostasis. Relates to erectile function. May improve treatment options for erectile dysfunction. (Rattus norvegicus) PubMed
792.
Down regulation of this protein's expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. (Rattus norvegicus) PubMed
Extensive smooth muscle and endothelial degradation was observed in the corpora cavernosa (CC) of diabetic penes, along with significantly decreased Shh protein in the smooth muscle of the CC. (Rattus norvegicus) PubMed
795.
One mechanism for formation of fistula tract is lack of proper Shh signaling because of Gli-2 deficiency, with subsequent straight, nonbranching caudal growth of fistula tract. (Rattus norvegicus) PubMed
796.
SHH signaling is important for prostatic growth, branching, and proliferation. (Rattus norvegicus) PubMed
797.
Cyclopamine, a potent inhibitor of hedgehog signalling, did not block the formation of oligodendrocytes from FGF2-treated neurospheres. (Rattus norvegicus) PubMed
798.
Sonic hedgehog can direct dopaminergic differentiation in proliferating dopaminergic neuroblasts in vitro. (Rattus norvegicus) PubMed
799.
TGF-beta is required for survival of mesencephalic dopaminergic neurons acting in cooperation with Shh and FGF8. (Rattus norvegicus) PubMed
800.
Shh plays a regulatory role in nerve injury. Facial nerve axotomy upregulates Sonic hedgehog (Shh) and its receptor Smoothened (Smo) in facial motor neurons of adult rats, but facial nerve axotomy does not upregulate mRNA of Shh or Smo in neonatal rats. (Rattus norvegicus) PubMed
801.
Data suggest a model for Sonic hedgehog function at high concentration to form and maintain papillae and, at low concentration, to activate between-papilla genes that maintain a papilla-free epithelium. (Rattus norvegicus) PubMed
802.
These results indicate that Shh promotes the proliferation of RGM-1 cells through an intracellular calcium- and ERK-dependent but transcription-independent pathway via Patched/Smoothened receptor system. (Rattus norvegicus) PubMed
803.
This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway. (Rattus norvegicus) PubMed
804.
These results show that SHH stabilizes the alterations of the corpora cavernosal smooth muscle following nerve injury. (Rattus norvegicus) PubMed
805.
Grafts survival was significantly prolonged after anti-Shh antibody treatment compared with the immunoglobulin G control. (Rattus norvegicus) PubMed
806.
Shh molecules are critical factors in the pathophysiology of inflammatory liver injury induced by ischemia and reperfusion. In addition, nitric oxide plays an important role in the immunohistochemical expression of these molecules. (Rattus norvegicus) PubMed
807.
Together, these results provide evidences that Muller glia act as potential stem cells in mammalian retina, Shh may have therapeutic effects on these cells for promoting the regeneration of retinal neurons. (Rattus norvegicus) PubMed
808.
These results identify Shh as an autocrine growth factor for myofibroblastic hepatic stellate cells (Rattus norvegicus) PubMed
809.
Results show that hypoxia induces the increase of IGF-2 and VEGF expression and the activation of their upstream regulatory genes, HIF-1alpha and Shh. (Rattus norvegicus) PubMed
810.
Neural activity and a trophic factor from the pelvic ganglia/CN are necessary to regulate SHH protein and smooth muscle abundance in the penis in the rat. (Rattus norvegicus) PubMed
811.
Data show that cultures of proliferating neurospheres of mesencephalic precursors treated with anti-sonic hedgehog antibodies show less serotonergic and GABAergic cells and more dopaminergic neurons generated from the neurospheres than control cultures. (Rattus norvegicus) PubMed
812.
Despite Ihh variability, the expressions of Dhh and Shh mRNA remained unchanged in early pregnancy. (Rattus norvegicus) PubMed
813.
Up-regulated expression of Shh in Schwann cells may play an important role in injured motor neurons through the induction of BDNF. (Rattus norvegicus) PubMed
814.
Data describe the role of retinoic acid receptor beta and alpha signalling in adult forebrain neural progenitor cells, and show that RARbeta activation stimulates Sonic hedgehog signalling and induces the cell proliferation. (Rattus norvegicus) PubMed
815.
study found Shh binds to caveolin-1, forming a protein complex in the Golgi apparatus & enters transport vesicles for delivery in lipid raft domains to the plasma membrane; alcohol exposure decreases formation of Shh/caveolin-1 complexes in lipid rafts (Rattus norvegicus) PubMed
816.
Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A (Rattus norvegicus) PubMed
817.
Robust changes in monoamine levels can regulate the expression of the Shh signaling cascade in the adult rodent brain. (Rattus norvegicus) PubMed
818.
pretreating the oligospheres by growth in the presence of Shh before transplantation is essential to induce their myelinating competence. (Rattus norvegicus) PubMed
819.
When Shh function is neutralized in vivo by its antibody, growth of newly generated olfactory sensory neuron axons into the glomeruli is vastly reduced. (Rattus norvegicus) PubMed
820.
This study demonstrated that A diffusible morphogen Shh was able to activate Semaphorin repulsion during midline crossing. (Rattus norvegicus) PubMed
821.
Shh pathway activity is involved in the high glucose condition mediated osteoblastic differentiation deficiency for bone marrow stromal cells and that recombinant Shh could alleviate this inhibitory effect. (Rattus norvegicus) PubMed
822.
findings support a novel dual lineage, Shh-independent and Shh-dependent, model of adrenocortical development (Rattus norvegicus) PubMed
823.
Western blotting showed higher expression of Shh in (Shh)MSCs which also led to increased expression of angiogenic and pro-survival growth factors in (Shh)MSCs (Rattus norvegicus) PubMed
824.
Shh and Smo are upregulated in a time-dependent manner in retinas exposed to ocular hypertension, and Shh has neuroprotective effects on damaged RGCs in a rat chronic hypertension model. (Rattus norvegicus) PubMed
825.
These findings demonstrate that interactions between Rac1 and the Hh pathway control the size of myofibroblastic hepatic stellate cells populations and have important implications for the pathogenesis of cirrhosis. (Rattus norvegicus) PubMed
826.
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. (Rattus norvegicus) PubMed
827.
The expression of sonic hedgehog (Shh) in the urethral epithelium of the proximal penis was significantly less in the DI(n-Butyl) phthalate (700 mg/kg/d)- or flutamide (25 mg/kg/d)-treated groups. (Rattus norvegicus) PubMed
828.
investigation of role of Shh in protection of insulin-secreting cells from pro-apoptotic effects of cytokines: overexpression of Shh reduced cytokine-induced apoptosis; inhibition of hedgehog signaling increased cytokine-induced apoptosis (Rattus norvegicus) PubMed
829.
SHH is upregulated in autogenous vein grafts and may be correlated with the proliferation of vascular smooth muscle cells. (Rattus norvegicus) PubMed
830.
Data demonstrate that activation of sonic hedgehog (SHH) signaling protects cortical neurons against oxidative stress and suggest a potential role of SHH for the clinic treatments of brain ischemia and neurodegenerative disorders. (Rattus norvegicus) PubMed
831.
BDNF-dependent SHH expression and 3-NP resistance require prior induction of EPO, thus establishing a signaling cascade of "BDNF-->EPO-->SHH-->3-NP resistance" in rat cortical neurons. (Rattus norvegicus) PubMed
832.
Data suggest that long-range Shh transport and signalling in neurons involves trafficking to the regulated secretory pathway and cell surface accumulation of Shh on axons and suggests a link between neuronal activity and Shh release. (Rattus norvegicus) PubMed
833.
Sonic hedgehog expression defines one cell population of the undifferentiated zone. (Rattus norvegicus) PubMed
834.
Data implicate Shh as a possible mechanistic link for specific neurodevelopmental effects of thyroid hormone. (Rattus norvegicus) PubMed
835.
Shh, Ptch1, and Gli1 were expressed in rat pulmonary microvascular endothelial cells and their expression decreased when cells were treated by lipopolysaccharide. (Rattus norvegicus) PubMed
836.
Shh may play an important role in the development of experimental temporal lobe epilepsy. (Rattus norvegicus) PubMed
837.
Sonic hedgehog modulates the progression toward oligodendrocytes by decreasing histone acetylation and inducing peripheral chromatin condensation. (Rattus norvegicus) PubMed
Development of hyperoxia-induced lung injury was associated with increases in lung Shh and Ptc1 mRNA and protein expression. (Rattus norvegicus) PubMed
840.
Shh is a key instructive molecule while other molecules secreted from insulted astrocytes may synergistically promote the de-differentiation event. (Rattus norvegicus) PubMed
841.
Shh derived from activated astrocytes stimulated RhoA/ROCK pathway in brain microvascular endothelial cells after oxygen-glucose deprivation. (Rattus norvegicus) PubMed
842.
significantly decreased SHH protein in prostatectomy and diabetic penis (Rattus norvegicus) PubMed
843.
The expression of Shh, Smo and Gli1 at the protein and mRNA level in hepatocytes of rats with chronic fluorosis can be increased by fluoride and may be inhibited by cyclopamine. (Rattus norvegicus) PubMed
844.
Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. (Rattus norvegicus) PubMed
845.
results suggest that the Shh pathway should be activated in the brain after SAH, and plays a beneficial role in SAH development. (Rattus norvegicus) PubMed
846.
Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels (Rattus norvegicus) PubMed
847.
Up-regulation of Shh signal transduction increases PC12 cell proliferation. (Rattus norvegicus) PubMed
specific and potent kidney tubule-derived growth factor that promotes interstitial fibroblast proliferation and activation (Rattus norvegicus) PubMed
850.
Shh could induce redifferentiation of dedifferentiated chondrocytes through up-regulating Shh signaling pathway (Rattus norvegicus) PubMed
851.
Maternal hypothyroxinemia and hypothyroidism reduced expression of the Shh signaling pathway. (Rattus norvegicus) PubMed
852.
Defective Shh signaling environment in the foregut is present beyond the emergence of lung buds and probably impairs lung development. Later in gestation, lungs exhibited a remarkable ability to upregulate the Shh cascade (Rattus norvegicus) PubMed
853.
Shh activates AMPK-dependent autophagy in cardiomyocytes under oxygen glucose deprivation, suggesting a role of autophagy in Shh-induced cellular protection. (Rattus norvegicus) PubMed
854.
IFT20 ablation impairs the dedifferentiation capacity of Muller cells induced by Shh and by glutamate. (Rattus norvegicus) PubMed
855.
angiogenesis and endothelial dysfunction we demonstrate here a novel cardio-protective effect of SHH acting directly on the cardiomyocytes. (Rattus norvegicus) PubMed
856.
This study demonstrated that Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation. (Rattus norvegicus) PubMed
857.
Shh protein signaling through the primary cilium modulates oligodendrocyte differentiation. (Rattus norvegicus) PubMed
858.
SHH but not GDNF controls the phenotypic fate and therapeutic efficacy of grafted neural precursor cells in a model of nigrostriatal neurodegeneration. (Rattus norvegicus) PubMed
859.
Hh signaling plays an important role in post-natal osteogenesis in the setting of stress fracture healing, mediating its effects directly through regulation of bone formation and angiogenesis. (Rattus norvegicus) PubMed
860.
SHH over expression may play a pivotal contribute role in vasculogenesis through activating the SHH signals in post-myocardial ischemic-reperfusion injury (Rattus norvegicus) PubMed
861.
These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity. (Rattus norvegicus) PubMed
862.
the activation of the SHH signaling pathway promotes the induction of EMT and renal tubulointerstitial fibrosis. (Rattus norvegicus) PubMed
863.
The results suggest that SHH-Gli pathway is involved in the pathogenesis of Rheumatoid arthritis, and blocking SHH-Gli pathway inhibits Rheumatoid arthritis-synovial fibroblast cell proliferation and increases cell apoptosis, which may shed light on developing new ideas for Rheumatoid arthritis treatment. (Rattus norvegicus) PubMed
864.
a positive role for Shh signaling, through the activator Smo, in oligodendrocyte differentiation after lineage specification. (Rattus norvegicus) PubMed
865.
the results provide critical insights into the newly discovered role of Shh in phenotypic modulation of vascular smooth muscle cells which depends on KLF4. (Rattus norvegicus) PubMed
866.
Tissue samples from fibrotic kidneys show enhanced TGF-beta1 levels, as well as upregulated hedgehog signaling activity, during the epithelial-mesenchymal transition process; these levels decrease when fibrosis is reversed. (Rattus norvegicus) PubMed
867.
'nNOS-Sox2-Shh' axis functions as a novel feedback compensatory mechanism to protect neurons against the early excitotoxicity and ischemic injury. (Rattus norvegicus) PubMed
868.
data suggest that CGRP can partly protect AECII cells from hyperoxia-induced injury, and the upregulation of CGRP may be a potential therapeutic approach with which to combat hyperoxia-induced lung injury, which may be associated with the activation of the SHH signaling pathway. (Rattus norvegicus) PubMed
869.
Data show that sonic hedgehog protein (SHH) was expressed mainly in the synaptic vesicles of hippocampus in both young postnatal and adult rats. (Rattus norvegicus) PubMed
870.
These results revealed the critical roles of Id1 and SHH mediating Abeta-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons. (Rattus norvegicus) PubMed
871.
Reintroduction of sonic hedgehog protein in an aged prostatectomy model is even more effective in promoting neurite formation/cavernous nerve regeneration than in adult. (Rattus norvegicus) PubMed
872.
Study provide evidence that spatiotemporal expression of Shh, Ptch1, and Gli1 was imbalanced during development of the lumbosacral spinal cord in rat embryos with ethylenethiourea induced anorectal malformations (ARMs). This imbalance may contribute to maldevelopment of the lumbosacral spinal cord and provide a molecular explanation for the complications observed in patients with ARMs. (Rattus norvegicus) PubMed
873.
the results of the present study indicated that HG inhibited the Shh pathway in osteoblasts and resulted in patterning defects during osteoblastic differentiation and bone formation, while the activation of Shh signaling could suppress these deleterious effects. (Rattus norvegicus) PubMed
874.
The Shh/Ptch1 pathway plays an essential role in the model of VD. (Rattus norvegicus) PubMed
induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase (Homo sapiens) PubMed
888.
The Tbx1 regulatory region was responsive to signaling by Sonic hedgehog (Shh) in vivo. (Homo sapiens) PubMed
889.
Down-reuglation of this protein's expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. (Homo sapiens) PubMed
890.
Role for hedgehog signaling in regeneration and carcinogenesis of airway epithelium (Homo sapiens) PubMed
891.
Aberrant Shh signaling may play a critical role in the pathogenesis of esophageal atresia with tracheoesophageal fistula in humans. (Homo sapiens) PubMed
892.
These studies are the first demonstration that mutations in SHH associated with human HPE (holoprosencephaly) perturb the in vivo patterning function of SHH in the developing nervous system. (Homo sapiens) PubMed
893.
deregulated hedgehog signaling in the genesis of basaloid follicular hamartomas (Homo sapiens) PubMed
894.
Adriamycin influences the Shh signalling pathway, resulting in disruption of normal development of the foregut. (Homo sapiens) PubMed
895.
model of the interactions between beta-catenin and hedgehog signaling in the epidermis in which SHH promotes proliferation of progenitors of the hair lineages whereas IHH stimulates proliferation of sebocyte precursors (Homo sapiens) PubMed
896.
In gray matter from brains of multiple sclerosis (MS) victims, the total amount of Shh was less than normals and the signaling 20 kDa protein was greatly reduced. (Homo sapiens) PubMed
897.
a wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity, which is suppressible by cyclopamine, a Hh pathway antagonist (Homo sapiens) PubMed
898.
Hedgehog pathway may have an early and critical role in the genesis of pancreatic cancer; maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis (Homo sapiens) PubMed
899.
Decreased expression of the Shh pathway in atrophic gastritis and gastric cancer might reflect altered differentiation processes within the gastric unit and contributes to the development of gastric atrophy. (Homo sapiens) PubMed
900.
Shh signaling has a role in the cellular proliferation of oral squamous cell carcinoma cells (Homo sapiens) PubMed
901.
signaling molecules might play a role in epithelial-mesenchymal interactions and cell proliferation in tooth development as well as in growth of [ameloblastomas] (Homo sapiens) PubMed
902.
SHH signalling can increase aberrant cell survival in colorectal tumour cells. (Homo sapiens) PubMed
903.
Thirteen novel SHH mutations found in a cohort of Holoprosencephaly patinets. (Homo sapiens) PubMed
904.
Overexpression of a wild-type regulatory subunit of protein kinase A is sufficient to activate sonic hedgehog target gene transcription. (Homo sapiens) PubMed
905.
Results identify REN(KCTD11) as a suppressor of Hedgehog signaling and suggest that its inactivation might lead to a deregulation of the tumor-promoting Hedgehog pathway in medulloblastoma. (Homo sapiens) PubMed
906.
sonic hedgehog mutations have a role in holoprosencephaly (Homo sapiens) PubMed
907.
Data report expression of sonic hedgehog-GLI-1 pathway components in adult human prostate cancer, often with enhanced levels in tumors versus normal prostatic epithelia. (Homo sapiens) PubMed
908.
Shh down-regulated in the precursor cell population the expression of IL-7R as well as stromal-derived factor-1 chemokine receptor, CXCR4, and inhibited IL-7-dependent STAT5 phosphorylation. (Homo sapiens) PubMed
909.
SHH signaling in inflammatory diseases of the gut acts to ensure stem cell restitution of damaged mucosal epithelium. (Homo sapiens) PubMed
910.
Taken together, our data suggest that the hedgehog pathway is weakly active in normal adult urothelial cells and of limited importance in transitional cell carcinoma. (Homo sapiens) PubMed
911.
ptc1 mutation enhances a downstream reporter of sonic hedgehog (shh)-ptc1 signaling. (Homo sapiens) PubMed
912.
an intact EGF signaling axis cooperates with shh and is a critical mediator of matrix invasion in a tumor type characterized by disrupted shh. (Homo sapiens) PubMed
913.
Elevated expression of hedgehog target genes human patched gene 1 (PTCH1) or Gli1 occurs in 63 of the 99 primary gastric cancers. (Homo sapiens) PubMed
914.
regulatory elements around the SHH gene may contribute to the maintenance of conserved synteny across human chromosome 7q36.3 (Homo sapiens) PubMed
915.
elevated expression of Shh and its target genes is quite common in esophageal cancers (Homo sapiens) PubMed
916.
Shh might maintain pituitary cells in nonproliferative state. Shh is newly described hypophysiotropic cytokine and its down-regulation may be involved in pathogenesis of pituitary adenomas. (Homo sapiens) PubMed
917.
SHH gene therapy may have considerable therapeutic potential in individuals with acute and chronic myocardial ischemia. (Homo sapiens) PubMed
918.
The effects of seven missense mutations associated with holoprosencephaly that affect the N-terminal signaling domain of SHH have been characterized (Homo sapiens) PubMed
919.
This review highlights the hypothesis of hedgehog pathway activation in damaged nerve tissue, inducing the repair process, as a potentially new approach to treatment of neurodegenerative diseases and dysfunction, including spinal cord injury. (Homo sapiens) PubMed
920.
Hedgehog signaling is conserved in hepatic progenitors from fetal development through adulthood and may be a new therapeutic target in patients with liver damage. (Homo sapiens) PubMed
921.
A pattern of strong Shh expression with weak expression of Foxf1 in all cases of UIP (usual interstitial pneumonitis) and a complementary expression of Shh and Foxf1 in cases of nonspecific interstitial pneumonitis (NSIP-F). (Homo sapiens) PubMed
922.
Rsults suggested that the increased and constitutive Shh expression is implicated in gastric carcinogenesis, and that promoter methylation may be an important regulatory mechanism of Shh expression. (Homo sapiens) PubMed
923.
Transgenic SHH signals cooperate with those of FGF9 to regulate mesenchymal proliferation in distinct submesothelial and subepithelial regions of developing lung. (Homo sapiens) PubMed
924.
Shh is an important regulator of human putative epidermal stem cell proliferation in the basal layer of fetal epidermis and modulates the cell responsiveness to EGF (Homo sapiens) PubMed
925.
Increased expression of SHh mRNA in human colonic adenocarcinomas and in a colorectal cell line. (Homo sapiens) PubMed
926.
SHH morphogens are associated with microvesicles (MVs) shed from the plasma membrane of apoptotic/stimulated T cells. (Homo sapiens) PubMed
927.
beta-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI (Homo sapiens) PubMed
928.
analysis of Hedgehog modulator properties after functional coupling of Smoothened to G15 (Homo sapiens) PubMed
929.
Expressions of Shh and Gli-1 were significantly higher in leiomyomas than in gastrointestinal stromal tumors. Expressions of Ptc and Smo did not correlate with histopathological differentiation. (Homo sapiens) PubMed
930.
sFRP-1, a target gene of the hedgehog pathway, is involved in cross-talk between the hedgehog pathway and the Wnt pathway (Homo sapiens) PubMed
931.
The results presented in this study implicate p63 in the regulation of the Shh signaling pathway. (Homo sapiens) PubMed
932.
Dignaling is clearly upregulated in gastrointestinal neuroendocrine carcinomas in a Gli1-dependent manner. (Homo sapiens) PubMed
933.
Mutations within ZRS of sonic hedgehog appear to be a common cause of familial triphalangeal thumb and preaxial polydactyly. (Homo sapiens) PubMed
934.
Results suggest that the SHH pathway may be a target to overcome MDR and increase chemotherapeutic response. (Homo sapiens) PubMed
935.
The metabolic pathway of SHH might have been responsible for the left side-restricted multiple fetal abnormalities reported. (Homo sapiens) PubMed
936.
The stronger Shh expression in intestinal metaplasia and gastric adenoma indicates that hedgehog protein is involved at an early phase of gastric carcinogenesis. (Homo sapiens) PubMed
937.
Melanomas require SHH-GLI signaling regulated by interactions bewteen GLI1 and the RAS-MEK/AKT pathways. (Homo sapiens) PubMed
938.
data support a direct molecular link between the Hh signaling pathway and SOX9 regulation, wherein SHH stimulates SOX9 through its mediator GLI1, and are consistent with a mechanism of SOX9 regulation through distal chromatin interactions (Homo sapiens) PubMed
939.
The quantitative expression of sHh signaling detected by Western blotting in pancretic cancer. (Homo sapiens) PubMed
940.
Shh-Ptch1-Gli1 signaling pathway may play a role in the progression of colorectal tumor. (Homo sapiens) PubMed
941.
Shh signaling enhanced K-Ras-mediated pancreatic tumorigenesis and reduced the dependence of tumor cells on the sustained activation of Ras-stimulated signaling pathways. (Homo sapiens) PubMed
942.
Expression of Shh ligand by glioblastoma multiforme cells is a mechanism for Hh pathway activation. Shh mRNA was found in many primary tumor samples, the highest level of expression being in the tumor with the most elevated Gli1 level. (Homo sapiens) PubMed
943.
Activin B is a potent inducer of Pdx1 as well as Shh in differentiating embryonic stem cell derived embryoid bodies (Homo sapiens) PubMed
944.
Protein kinase A, not Epac, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells (Homo sapiens) PubMed
945.
Snail and SHH are overexpressed in a large subset of neuroendocrine tumors of the ileum. (Homo sapiens) PubMed
946.
SHH and EGFR signal pathways are active in pancreatic carcinoma, and are closely correlated to cancer cell proliferation. SHH and EGFR expression were positively correlated to PCNA expression. (Homo sapiens) PubMed
947.
we focus on the SHh signaling pathway and its role in gastrointestinal (GI) tract development and maintenance and consider the diseases resulting from aberrant SHh activity--REVIEW (Homo sapiens) PubMed
948.
The congenital abnormality preaxial polydactylya is caused by ectopic expression of the Sonic Hedgehog (SHH) in the developing limb bud. (Homo sapiens) PubMed
949.
are the first to suggest a role and mechanism for Shh signaling as it relates to the metastatic potential of gastric cancer, thereby indicating potential therapeutic molecular targets to decrease metastasis (Homo sapiens) PubMed
950.
A novel microduplication in 7q36.3 results in a similar triphalangeal thumb and polysyndactyly phenotype as caused by single nucleotide alterations in the ZRS, the limb specific SHH regulatory element. (Homo sapiens) PubMed
951.
In the adult stomach, Shh is expressed and secreted from the acid-producing parietal cells, where it is believed to play an essential role in gastric tissue homeostasis and normal differentiation of the epithelium. (Homo sapiens) PubMed
952.
These findings show that human embryonic stem cells contain primary cilia associated with working Hedgehog machinery. (Homo sapiens) PubMed
953.
SHH germline defects may be rarely involved in the pathogenesis of human thyroid dysgenesis (Homo sapiens) PubMed
954.
Point mutations in the ZPA regulatory sequence (ZRS), a long range cis-regulator for the SHH gene, and duplications encompassing the ZRS cause distinctive limb phenotypes. (Homo sapiens) PubMed
955.
Overexpression of sonic hedgehog is associated with angiogenesis in pancreatic cancer (Homo sapiens) PubMed
956.
SHH and Gli1 mRNAs are likely to be up-regulated from adenoma and from borderline to carcinoma cells, respectively, in intraductal papillary mucinous neoplasm of the pancreas (Homo sapiens) PubMed
957.
A dominant mutation in the sonic hedgehog regulatory sequence is associated with the common cause of triphalangeal thumb in southern England. (Homo sapiens) PubMed
958.
These results indicate a significant role for Shh-GLI signaling in the proliferation of mantle cell lymphoma. (Homo sapiens) PubMed
959.
Both the Shh precursor and mature protein are N-palmitoylated by Hhat, and the reaction occurs during passage through the secretory pathway (Homo sapiens) PubMed
960.
the onset of Hh signaling from human embryogenesis to fetal development is associated with accumulation of Hh signaling components Smo and Gli2 in pancreatic duct primary cilia and a reduction of Gli3 in the duct epithelium (Homo sapiens) PubMed
961.
Tested variants are not associated with anorectal malformations and most are predicted to be benign. (Homo sapiens) PubMed
962.
Conjunctival epithelium constitutively expresses a low level of Shh, and its expression increases during malignant conversion of epithelial cells. (Homo sapiens) PubMed
Pint mutations in patients with type 2 diabetes and their families were studied. mitochondrial genes including np3316, np3394 and np3426 in the ND1 region and np3243 in the tRNA(Leu(UUR))were screened. (Homo sapiens) PubMed
965.
The role of NF-kappaB in SHH expression, and the implications for cancer therapy, are reported. (Homo sapiens) PubMed
966.
investigate the involvement of the SSH pathway in Smith-Lemli-Opitz syndrome-affected individuals developing tumors (Homo sapiens) PubMed
967.
Down-regulation of SHH signaling pathway activity is involved in 5-fluorouracil-induced apoptosis and mobility inhibition in Hep3B cells. (Homo sapiens) PubMed
968.
SHH-dependent and -independent brain tumor growth require phosphoinositide 3-kinase-mammalian target of rapamycin signaling; PTEN has a role in shorter survival time (Homo sapiens) PubMed
969.
its signal transduction regulates tumor development. (review) (Homo sapiens) PubMed
970.
SHH contributes to the formation of desmoplasia in pancreatic cancer (Homo sapiens) PubMed
971.
These data suggest a direct link between Six3 and Shh regulation during normal forebrain development and in the pathogenesis of holoprosencephaly.[SBE2] (Homo sapiens) PubMed
972.
Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. (Homo sapiens) PubMed
973.
NRP-1 knockdown RCC cells exhibit a more differentiated phenotype, as evidenced by the expression of epithelial-specific and kidney-specific cadherins, and the inhibition of sonic hedgehog expression participated in this effect (Homo sapiens) PubMed
974.
Shh signaling regulates Sufu activity by inducing its turnover via the ubiquitin-proteasome system. (Homo sapiens) PubMed
975.
Hh targets CATB, and Hh signaling through CATB might influence pancreatic cancer cell invasiveness (Homo sapiens) PubMed
976.
human tumor suppressor SUFU has a role in Hedgehog signaling [review] (Homo sapiens) PubMed
977.
Results show that SHH holoprosencephaly missense mutations affect SHH biogenesis and signaling at multiple steps, which results in low levels of protein expression, defective processing of SHH into its active form and protein with reduced activity. (Homo sapiens) PubMed
978.
Hh signaling is important in the pathogenesis of B-CLL and, hence, may be a potential therapeutic target (Homo sapiens) PubMed
979.
Hedhog traget genes show increased transcript levels in hepatoblastoma samples. (Homo sapiens) PubMed
980.
A novel connection between HH/GLI pathway activity and JUN, which may contribute to the oncogenic activity of HH/GLI signaling in skin. (Homo sapiens) PubMed
981.
Sonic hedgehog and pancreatic-duodenal homeobox 1 expression distinguish between duodenal and pancreatic gastrinomas. (Homo sapiens) PubMed
982.
SHH/GLI1 signaling pathway is activated in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL). (Homo sapiens) PubMed
983.
Shh-expressing prostate cancer cells can directly and specifically induce differentiation in pre-osteoblasts. (Homo sapiens) PubMed
984.
A duplication of the long-range sonic hedgehog (SHH) regulator (ZRS) at 7q36.3 causes syndactyly type IV with tibial hypoplasia in a family with eight affected individuals. (Homo sapiens) PubMed
985.
sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2, NKX2.2 and SOX10 is required for sequential specification of ventral spinal OLIG2-expressing progenitors (Homo sapiens) PubMed
986.
Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A (Homo sapiens) PubMed
987.
sonic hedgehog protein was significantly reduced in endometrial carcinoma compared with the hyperplastic endometrium (Homo sapiens) PubMed
988.
Results present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh. (Homo sapiens) PubMed
989.
Increased Shh and VEGF-A expression is correlated with an aberrant lymphatic endothelial differentiation in trisomy 21 fetuses. (Homo sapiens) PubMed
990.
Results propose a role for Hedgehog-interacting protein as a structural decoy receptor for vertebrate Hedgehog. (Homo sapiens) PubMed
991.
Studies suggest that Hh binding to Ptc leads to the de-repression of the GPCR-related protein Smo. (Homo sapiens) PubMed
992.
Shh-mediated epithelial-mesenchymal transition in ductular cells contributes to the pathogenesis of cirrhosis in nonalcoholic fatty liver disease. (Homo sapiens) PubMed
993.
Sonic hedgehog protein, GLI1-3 and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma. (Homo sapiens) PubMed
994.
combined structural analysis suggests that dysfunction of Hedgehog signaling in human forebrain development can occur through truncations or major structural changes to the signaling domain, SHH-N (Homo sapiens) PubMed
995.
Our study has revealed a molecular mechanism for the persistent activation of the SHH pathway which promotes the development of neuroblastoma. (Homo sapiens) PubMed
996.
SHH, secreted from pancreatic epithelia, is critical in establishing and regulating the tumor microenvironment and thereby contributes to progression of pancreatic cancer. (Homo sapiens) PubMed
997.
Shh signaling pathway is crucial for the growth of olfactory neuroblastoma (ONB). (Homo sapiens) PubMed
998.
changes in the prostate stroma due to association with cancer result in an altered transcriptional response to Hh that mimics the growth-promoting actions of the fetal mesenchyme. (Homo sapiens) PubMed
999.
in hypertrophic chondrocytes, HS-assisted, TG-mediated Hh oligomerization modulates signaling via enhanced protein signaling activity (Homo sapiens) PubMed
1000.
Coordination of SHH and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. (Homo sapiens) PubMed
1001.
findings implicate YAP1 as a new Shh effector that may be targeted by medulloblastoma therapies aimed at eliminating medulloblastoma recurrence. (Homo sapiens) PubMed
1002.
Sonic hedgehog is expressed in the developing optic chiasm in retinal ganglion cell axons. (Homo sapiens) PubMed
1003.
Shh-related carcinogenesis and Shh expression may be a trigger for the adenoma- carcinoma sequence (Homo sapiens) PubMed
1004.
Late reactivation of sonic hedgehog by H. pylori infection results in population of gastric epithelial cells that are resistant to apoptosis and imposes proliferative changes under the background of atrophic gastritis, providing the carcinogenic basis. (Homo sapiens) PubMed
1005.
in some physiological contexts full-length HH proteins may participate directly in HH signaling and that this novel activity of full-length HH may be evolutionarily conserved (Homo sapiens) PubMed
1006.
Studies indicate that signaling pathways of STAT3, NOTCH, hedgehog and transforming growth factor-beta (TGFbeta), which are involved in stem cell renewal, differentiation, survival, and are commonly deregulated in HCC. (Homo sapiens) PubMed
1007.
potent chemoattractant for monocytes and activates classical signaling pathways related to migration; signaling negatively affected by diabetes mellitus (Homo sapiens) PubMed
1008.
plays a minimal role in maintaining pluripotency and regulating proliferation of undifferentiated human embryonic stem cells. (Homo sapiens) PubMed
1009.
These data provide the first evidence that Werner mesomelic syndrome is caused by a specific ZRS mutation, which leads to strong ectopic SHH expression, and ZRS duplication leads to Haas polysyndactyly or triphalangeal thumb-polysyndactyly syndrome. (Homo sapiens) PubMed
1010.
HH signaling suppresses peripheral neuroblastic tumor growth by promoting differentiation along alternative neural crest pathways (Homo sapiens) PubMed
1011.
Pancreatic duct glands may provide a link between Shh, mucinous metaplasia, and neoplasia. (Homo sapiens) PubMed
1012.
The ERalpha pathway promotes cell proliferation by activating the Hh pathway in a ligand-dependent manner through Shh induction of ERalpha-positive gastric cancer. (Homo sapiens) PubMed
1013.
Expression of SHH, GLI family zinc finger 2 (GLI2) and BMP4 mRNA and protein in the posterior wall of the terminal rectum in 40 patients with orectal malformations, were assessed. (Homo sapiens) PubMed
1014.
Shh is likely an important soluble dopaminergic inducing factor secreted by stromal cells and acts after the neural fate determination. (Homo sapiens) PubMed
1015.
Data suggest a novel mechanism in which PKA down-regulates Hedgehog signaling by promoting the interaction between 14-3-3 and Gli as well as proteolysis. (Homo sapiens) PubMed
1016.
inflammation-stimulated monocytes produce Shh through activation of the NF-kappaB signaling pathway (Homo sapiens) PubMed
1017.
Using zebrafish transgenic lines, a model is generated in which Hedgehog functionally orients the development of the inner ear towards an auditory fate in all vertebrate species. (Homo sapiens) PubMed
1018.
mutation analysis of SHH in a group of 10 patients who fulfilled three or more of the criteria for VACTERL association did not demonstrate any evidence of sequence changes (Homo sapiens) PubMed
1019.
inhibition of the SHH pathway induced tumor regression in nude mice through inhibition of cell proliferation and neo-vascularization, and induction of apoptosis but not senescence assessed by in vivo studies, immunoblot and immunohistochemistry (Homo sapiens) PubMed
1020.
This result provides evidence that mutations in the SHH gene can explain some of the sporadic holoprosencephaly cases. (Homo sapiens) PubMed
1021.
This review focuses on the most recent data of the Hedgehog pathway in the adult brain and its relevance as a novel therapeutic approach for brain diseases including brain tumors--REVIEW (Homo sapiens) PubMed
1022.
Shh can promote proliferation, migration and phenotypic modulation of vascular adventitial fibroblasts. (Homo sapiens) PubMed
1023.
Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. (Homo sapiens) PubMed
1024.
SHH overexpression, possible consequence of promoter hypomethylation, could play a role in the carcinogenesis of primary colorectal cancers. (Homo sapiens) PubMed
1025.
In line with a redirection of autocrine toward paracrine HH signaling by a KRAS-DYRK1B network, we find high levels of GLI1 expression restricted to the stromal compartment and not to SHH-expressing tumor cells in pancreatic adenocarcinoma. (Homo sapiens) PubMed
1026.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
1027.
These findings demonstrate that interactions between Rac1 and the Hh pathway control the size of myofibroblastic hepatic stellate cells populations and have important implications for the pathogenesis of cirrhosis. (Homo sapiens) PubMed
1028.
study shows that IL-7Ralpha Y449 is important for lymphocyte transformation (Homo sapiens) PubMed
1029.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
1030.
Shh/Gli2 signaling stimulates vascular smooth muscle cell proliferation via regulation of the G(1) cyclin-retinoblastoma axis. (Homo sapiens) PubMed
1031.
the role of SHH signaling in developmental eye anomalies (Homo sapiens) PubMed
1032.
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. (Homo sapiens) PubMed
1033.
Results indicate that in addition to c-Myc, mir-29b-1/mir-29a expression can be suppressed by hedgehog signaling and inflammatory pathways, both commonly activated in the genesis of malignancies. (Homo sapiens) PubMed
1034.
UVR cause mutation in PATCHED gene encoding Ptch1 protein which led to deregulation of sonic hedgehog pathway through activation of Smo protein and Gli transcriptional factors that stimulate cell proliferation causing non melanoma skin cancers. (Homo sapiens) PubMed
1035.
screened four known HPE genes in a Dutch cohort of 86 non-syndromic HPE index cases, including 53 family members. We detected 21 mutations (24.4%), 3 in SHH, 9 in ZIC2 and 9 in SIX3 (Homo sapiens) PubMed
1036.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
1037.
Observational study of gene-disease association. (HuGE Navigator) (Homo sapiens) PubMed
1038.
Data show that the putative Wnt/beta-catenin targets Sonic hedgehog and JAG2 control beta-catenin signaling in the adult tongue epithelium, a function that is partially lost in lingual squamous cell carcinoma. (Homo sapiens) PubMed
1039.
sonic hedgehog (SHH) hypomethylation could lead to the SHH dependent activation of Hedgehog pathway in colorectal cancers (Homo sapiens) PubMed
1040.
proteins of the SHH signaling pathway are predominantly located within the epithelial components of GOCs and DCs. SHH signaling pathway may play a role in epithelial lining formation. (Homo sapiens) PubMed
1041.
Studies indicate that understanding the contributions of Notch, Wnt and HH signaling to the development of hematopoiesis is critical for achieving successful ex vivo expansion and differentiation of hematopoietic stem cells hematopoietic stem cells. (Homo sapiens) PubMed
1042.
GLI1, which has been shown to play a central role in SHH signaling in prostate cancer, can act as a co-repressor to substantially block androgen receptor (AR)-mediated transactivation, at least in part, by directly interacting with AR. (Homo sapiens) PubMed
1043.
Sonic hedgehog signalling is active in Type-II alveolar epithelial cells from three types of Idiopathic interstitial lung diseases (Homo sapiens) PubMed
1044.
sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 are differently regulated in medulloblastoma and astrocytoma (Homo sapiens) PubMed
1045.
These results confirm previously reported results suggesting that aberrant CDX2 and Sonic hedgehog (SHH) are highly expressed in Barrett's epithelium and may play a crucial role in the development of Barrett's epithelium. (Homo sapiens) PubMed
1046.
Activation of the Hh signaling pathway in neuroblastoma & ganglioneuroblastoma may be associated with the differentiation. 73% of the cases were positive for Shh expression. (Homo sapiens) PubMed
1047.
WNT8b and SHH mutations and abnormal expressions are present in the peripheral blood of children with sporadic Hirschsprung disease. (Homo sapiens) PubMed
1048.
Shh increased expression of GLI1 and PTC-1 and selectively stimulated cell proliferation in STRO-1(+) derived from adult periodontal ligament. Shh plays critical role in regulation of cell proliferation in STRO-1(+)/HPLSC. (Homo sapiens) PubMed
1049.
hypoxia could activate the hedgehog signaling pathway in pancreatic ductal adenocarcinoma cells by increasing transcription of Smo, but not Shh. (Homo sapiens) PubMed
1050.
Sonic hedgehog might play a pivotal role during tumorigenesis of pancreatic adenocarcinoma, and high Shh expression might be associated with the malignant potential of pancreatic cancer. (Homo sapiens) PubMed
1051.
Data show that it is primarily Hh-induced VEGF-A that promotes angiogenesis in vitro and augments tumor-derived VEGF to promote angiogenesis in vivo. (Homo sapiens) PubMed
1052.
DNA methylation combined with alternative promoter usage coordinate genetic transcription of SHH. (Homo sapiens) PubMed
1053.
Pulsatile flow promotes BREC survival and enhances BRP apoptosis through modulation of Notch and hedgehog pathways. These interactions have important implications for the pathogenesis of retinopathies. (Homo sapiens) PubMed
1054.
Shh pathway activation leads to Sna1 induction in medulloblastoma cells. (Homo sapiens) PubMed
1055.
Shh, Ptch1, and Gli1 were expressed in rat pulmonary microvascular endothelial cells and their expression decreased when cells were treated by lipopolysaccharide. (Homo sapiens) PubMed
1056.
Data report mutations in the KIF7 gene, a known regulator of sonic hedgehog signaling and a putative ciliary motor protein, in Joubert syndrome patients. (Homo sapiens) PubMed
1057.
Shifting the balance from paracrine towards autocrine signalling of the hedgehog pathway is important in the pathogenesis and progression of prostate carcinoma. (Homo sapiens) PubMed
1058.
Results suggest a role for Shh in human male genital development. (Homo sapiens) PubMed
1059.
Sonic hedgehog signaling is activated in oral squamous cell carcinoma and suggest that this pathway mediates its tumorigenesis. (Homo sapiens) PubMed
1060.
Active Shh-mediated signaling was demonstrated between androgen independent prostate cancer and prostate fibroblasts in a paracrine- and tumor progression-dependent manner. (Homo sapiens) PubMed
1061.
All three mutations of hedgehog proteins affected protein binding to the receptor Patched1 (PTC1), reducing its capacity to induce cellular differentiation. (Homo sapiens) PubMed
1062.
findings establish that Shh signaling promotes the metastasis of gastric cancer through activation of the PI3K/Akt pathway, which leads to mesenchymal transition and MMP-9 activation (Homo sapiens) PubMed
1063.
None of the sinus tracts or cysts in 81 hidradenitis suppurativa histological slides from 34 patients showed positive finding for sonic hedgehog mutation. (Homo sapiens) PubMed
1064.
astrocytes secrete SHH and blood-brain barrier(BBB)ECs express Hedgehog receptors, which together promote BBB formation and integrity;Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks (Homo sapiens) PubMed
1065.
Significant correlation was found between renal/urinary defects and mutations of SHH and ZIC2. The most severe holoprosencephaly types were associated with SIX3 and ZIC2 mutations, whereas microforms were associated with SHH mutations. (Homo sapiens) PubMed
1066.
Hedgehog pathway in the adult brain and its relevance as a novel therapeutic approach for brain diseases including brain tumors. (Homo sapiens) PubMed
1067.
findings define a new medulloblastoma subgroup characterized by a functional interaction between the SHH and CXCR4 pathways, and they provide a rationale to clinically evaluate combined inhibition of SHH and CXCR4 for medulloblastoma treatment (Homo sapiens) PubMed
1068.
a new insight into the functional roles of hShh interactions with HSPGs, which may allow targeting this aspect of hShh biology in, for example, pancreatic ductal adenocarcinoma. (Homo sapiens) PubMed
1069.
Knockdown experiments of Bmi1 in vitro and in vivo demonstrate that Hh signaling not only drives Bmi1 expression, but a feedback mechanism exists wherein downstream effectors of Bmi1 may, in turn, activate Hh pathway genes (Homo sapiens) PubMed
1070.
Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. (Homo sapiens) PubMed
1071.
Data show that single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (NR5A2) were found to be associated with pancreatic cancer risk. (Homo sapiens) PubMed
1072.
Helicobacter pylori eradication can enhance SHH and its downstream regulators expression diminishing SHH methylation and reverse gastric phenotype, but not in the patients with high risk for gastric cancer. (Homo sapiens) PubMed
1073.
Studies indicate that pathways of Hedgehog (Hh), Wnt and Notch, which regulate development during embryonic life and somatic stem cells (SCs) in the adult organism, can be reactivated in malignancies and support tumor-initiating cells (TIC) scompartment. (Homo sapiens) PubMed
1074.
RACK1 activated sonic hedgehog signaling pathway by interacting with and activating Smoothened to mediate Gli1-dependent transcription in NSCLC cells. (Homo sapiens) PubMed
1075.
Stable miR-302-367 cluster expression results in inhibition of CXCR4 leading to the disruption of the sonic hedgehog (SHH)-GLI-NANOG network. (Homo sapiens) PubMed
1076.
Sonic Hedgehog-activated engineered blood vessels enhance bone tissue formation (Homo sapiens) PubMed
1077.
SHH stimulated osteoclast formation in a co-culture system consisting of murine bone stromal ST2 cells and murine CD11b(+) bone marrow cells. (Homo sapiens) PubMed
1078.
Sonic hedgehog may play an important role in the development of temporal lobe epilepsy. (Homo sapiens) PubMed
1079.
Sonic hedgehog signaling during adrenal development. (Homo sapiens) PubMed
1080.
Autoactivated Shh signaling provides survival and proliferative cues in CML progenitor cells through downstream beta-catenin signaling. (Homo sapiens) PubMed
1081.
Data provide significant insights into transcriptional targets in SHH-mediated neural differentiation of embryonic stem cells (hESC). (Homo sapiens) PubMed
1082.
The present study provides evidence that tPA and PAI-1 contribute to Shh-induced in vitro cerebral angiogenesis. (Homo sapiens) PubMed
1083.
Mutations in SHH is associated with holoprosencephaly. (Homo sapiens) PubMed
1084.
High SHH protein is associated with bladder cancer progression. (Homo sapiens) PubMed
1085.
In humans there appears to be a stage of Shh signaling within the external granular layer, when the Purkinje cells (PC) are not yet the source of Shh and expression of Shh in the PC in the postnatal human cerebellum is downregulated. (Homo sapiens) PubMed
1086.
findings are the first to report a correlation between SHH, BDNF and OFR in autistic children, suggesting a pathological role of oxidative stress and SHH in autism spectrum disorders (Homo sapiens) PubMed
1087.
Hh signaling pathway mediates invasion and metastasis of human hepatocellular carcinoma by up-regulating the protein expression of MMP-9 via ERK pathway. (Homo sapiens) PubMed
1088.
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group (Homo sapiens) PubMed
1089.
findings demonstrate that folate deprivation enhanced invasiveness of colon cancer cells mediated by activation of Shh signaling through promoter hypomethylation and cross actions with the NF-kappaB pathway (Homo sapiens) PubMed
1090.
analysis of the crosstalk between TGF-beta and hedgehog signaling in cancer [review] (Homo sapiens) PubMed
1091.
Our study has revealed a molecular mechanism for the persistent activation of the Sonic Hedgehog (SHH) pathway which promotes the development of NB, and suggests a new approach for the treatment of this childhood malignant tumor. (Homo sapiens) PubMed
1092.
High sonic hedgehog protein expression is associated with colon cancer. (Homo sapiens) PubMed
1093.
a novel, VEGF-independent, clinically relevant, pro-angiogenic factor, CYR61, that is a transcriptional target of Hh-GLI signaling (Homo sapiens) PubMed
1094.
Sonic hedgehog (Shh)-modified human CD34-positive cells protect against ventricular dilation and cardiac functional decline associated with experimental acute myocardial infarction. (Homo sapiens) PubMed
In the presence of exogenous ascorbic acid, mouse MC3T3 pre-osteoblasts in mixed cultures with LNCaP cells or LNCaP cells modified to overexpress Shh (LNShh cells) formed collagen matrix with distinct fibril ultrastructural characteristics. (Homo sapiens) PubMed
1097.
A fate map of the hypothalamus is defined, based on expression of sonic hedgehog (Shh) transgene in the hypothalamic progenitor zones. Large neurogenic Shh-expressing progenitor domains of ventral diencephalon are continuous with those of the midbrain. (Homo sapiens) PubMed
1098.
The sonic hedgehog pathway is activated in thyroid neoplasms and can contribute to increased cell proliferation. (Homo sapiens) PubMed
1099.
characterized the gene expression profiles related to the EMPs, SHH, and NOTCH signaling pathway and confirmed that cyclopamine significantly arrested the growth of KCOT-1 cells and may be a viable agent as a novel therapeutic (Homo sapiens) PubMed
1100.
These studies show that (1)(3)(1)I-SHH is capable of in vivo detection of breast tumors with high HH signaling. (Homo sapiens) PubMed
1101.
Expressions of Shh, Ptch1 and Gli1 were significantly correlated with stage, lymph node metastasis, venous invasion, hepatic infiltration, survival rate, and lymphatic invasion in gallbladder carcinoma. (Homo sapiens) PubMed
1102.
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis. (Homo sapiens) PubMed
1103.
SHH and NELL-1 directed signaling produced additive effects on the pro-osteogenic and antiadipogenic differentiation of adipose derived stem cells. (Homo sapiens) PubMed
1104.
Data suggest that targeting Hedgehog (Hh) pathway alone or in combination with PI3K/AKT pathway could be a novel therapeutic option in treating endocrine-resistant breast cancer. (Homo sapiens) PubMed
1105.
The hedgehog pathway gene SNPs studied, along with the Vitamin D Receptor and FAS SNPs studied, are not strongly associated with the Basal cell carcinoma cancer-prone phenotype. (Homo sapiens) PubMed
1106.
report of a new point mutation within the ZRS in a family with digit malformations including triphalangeal thumb, pre-axial polydactyly and post-axial polydactyly; heterozygous C>A mutation at position 287 of the ZRS enhancer was detected in all affected subjects and is absent from four unaffected family members (Homo sapiens) PubMed
1107.
Shh signaling defects could contribute to the vermis hypoplasia observed in Joubert syndrome and Meckel syndrome. (Homo sapiens) PubMed
1108.
SHH mutations more commonly resulted in non-chromosomal holoprosencephaly than frank HPE. Individuals with truncating mutations were significantly more likely to have frank HPE than those with non-truncating mutations. (Homo sapiens) PubMed
1109.
Results indicate that sonic hedgehog overexpression may be a marker of good prognosis in gastric cancer. (Homo sapiens) PubMed
1110.
PN1 regulates Hh signaling by decreasing protein levels of the Hh ligand Sonic (SHH) and its downstream effectors. (Homo sapiens) PubMed
1111.
mean levels of sonic hedgehog protein in human blood were lower in patients with pancreatitis and pancreatic cancer than in healthy subjects (Homo sapiens) PubMed
1112.
High SHH expression is associated with colorectal cancer. (Homo sapiens) PubMed
1113.
the matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis (Homo sapiens) PubMed
1114.
CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB (Homo sapiens) PubMed
1115.
The Sonic Hedgehog (SHH) pathway is activated in idiopathic pulmonary fibrosis (IPF) lungs and may contribute to IPF pathogenesis by increasing the proliferation, migration, extracellular matrix production, and survival of fibroblasts. (Homo sapiens) PubMed
1116.
These findings define residues and regions within Shh that are necessary for its recognition as a substrate for Hhat-mediated palmitoylation. (Homo sapiens) PubMed
1117.
A novel point mutation within the SHH long-range regulator ZRS was found in family members with preaxial polydactyly/triphalangeal thumb and one with radial ray deficiency. (Homo sapiens) PubMed
1118.
document enhanced SHH pathway activation and GLI3-target gene induction coincident with impaired recruitment of CDK8 onto promoters of GLI3-target genes, but not non-GLI3-target genes (Homo sapiens) PubMed
1119.
Suggest that the SHH gene could potentially be associated with male sexual orientation. (Homo sapiens) PubMed
1120.
Disp and Scube cooperate to dramatically enhance the secretion and solubility of the cholesterol-modified Hh ligand. (Homo sapiens) PubMed
1121.
findings suggest that SHH pathway induces cell migration and invasion through FAK/AKT signaling-mediated MMP-2 and MMP-9 production and activation in liver cancer (Homo sapiens) PubMed
1122.
The group with metastasis showed higher expression levels of Shh, ABCG2, and Wnt than did the group without metastasis (Homo sapiens) PubMed
1123.
Colorectal adenocarcinoma specimens showed stronger staining of Shh, Gli1, VEGFC, and VEGFR3 compared with a normal specimen. Shh expression was not associated with Gli1 expression. (Homo sapiens) PubMed
1124.
Results suggest that hypoxia-induced increase of Smo directly contributes to the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells through a hedgehog/Gli1-independent pathway. (Homo sapiens) PubMed
1125.
This study supports the presence of autocrine Hedgehog signaling in human cholangiocellular carcinoma, where tumor cells produce and respond to Shh ligand. (Homo sapiens) PubMed
1126.
Controlled mechanisms that specify neural subtypes operate in the sonic hedgehog-expressing progenitor domain. (Homo sapiens) PubMed
1127.
Results indicate that overexpression of VHL may antagonize Hedgehog-Gli activation at the post-translational level in Hedgehog pathway-induced cancers (Homo sapiens) PubMed
1128.
Promoter hypermethylation of SHH gene is associated with Basal Cell Carcinoma. (Homo sapiens) PubMed
1129.
duplication of 7q36.3 including SHH gene was found in 2 siblings with congenital muscular hypertrophy. (Homo sapiens) PubMed
1130.
SHH enhanced drug resistance in the pancreatic ductal adenocarcinoma cells (Homo sapiens) PubMed
1131.
2 mutations in the holoprosencephaly (HPE)-related genes were detected (c.799 C>T, p.Q267X in TGIF gene and c.1279G>A, p.G427R in SHH gene) in 2 patients with pituitary stalk interruption syndrome (PSIS); data suggest HPE-related gene mutations are implicated in the etiolog of isolated pituitary defects (Homo sapiens) PubMed
1132.
Results suggest involvement of the Hedgehog pathway in CPHD and that both SHH and HHIP are investigated as a second screening in CPHD, after mutations in the classical CPHD genes have been ruled out. (Homo sapiens) PubMed
1133.
Data indicate that transcription factor Sox2 is expressed in Sonic hedgehog (SHH)-associated medulloblastoma. (Homo sapiens) PubMed
1134.
Data indicate that Shh, Ptch1, Gli1, and Gli2 mRNA expressions were markedly increased in intrahepatic cholangiocellular carcinoma (ICC). (Homo sapiens) PubMed
1135.
Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. (Homo sapiens) PubMed
1136.
While autonomous Gli activity controls non-small cell lung cancer (NSCLC) proliferation, increased Shh expression by NSCLC is associated with fibroblast activation in tumor-associated stroma. (Homo sapiens) PubMed
1137.
Precise titration of GLI repressor transgene levels by SHH signaling is critical to multiple functions of adult neural stem cells and astrocytes. (Homo sapiens) PubMed
1138.
Sonic Hedgehog (Shh) protein stimulates cell proliferation and induces internalization of the Patched (Ptch) protein (Homo sapiens) PubMed
1139.
Epstein Barr virus activates the hedgehog signalling pathway through autocrine induction of SHH ligand. (Homo sapiens) PubMed
1140.
Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway. (Homo sapiens) PubMed
1141.
the SHH and PI3K pathways synergize to promote tumor growth and viability in PTEN-deficient glioblastomas (Homo sapiens) PubMed
1142.
Shh binds to HSPG co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation. (Homo sapiens) PubMed
1143.
Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. (Homo sapiens) PubMed
1144.
We further indicated that SHH and IHH were highly expressed in metastatic tumors (Homo sapiens) PubMed
1145.
The study thus reveals an intricate crosstalk among the Notch1, Shh and Akt pathways wherein Notch1 emerges as a key regulator of erythropoiesis. (Homo sapiens) PubMed
1146.
Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli. (Homo sapiens) PubMed
1147.
significantly decreased SHH protein in prostatectomy and diabetic penis (Homo sapiens) PubMed
1148.
Our results suggest that the SHH signaling pathway is constitutively active in ameloblastoma and plays an anti-apoptotic role in the proliferation of ameloblastoma cells (Homo sapiens) PubMed
1149.
under ischemic insults, Shh plays a role in tight junction repair and amelioration of the brain edema and blood-brain barier leakage (Homo sapiens) PubMed
1150.
Data indicate that the Shh signaling transduction is facilitated by binding of Shh to its receptor protein, Ptch, and show the complex structure of Shh-Hhip. (Homo sapiens) PubMed
1151.
survival analysis and immunohistochemistry identified CDA, EDIL3, ITGB4, PLAUR and SPOCK1 as SHH-dependent stromal factors that are associated with poor prognosis in PDAC (Homo sapiens) PubMed
1152.
The findings show that immunohistochemistry with FGF10, FGFR2b, or SHH could be useful in differentiating CCAM from type I PPB, when a child presents with a focal cystic lung lesion. (Homo sapiens) PubMed
1153.
an essential role for both primary cilia assembly and disassembly in the control of Hh signaling and early differentiation in muscle cells. (Homo sapiens) PubMed
1154.
Overexpression of SHH enhances prostate cancer cell lines resistance to paclitaxel. (Homo sapiens) PubMed
1155.
Low expression of Sonic hedgehog signaling proteins is related to lepidic predominant subtype in primary lung adenocarcinoma. (Homo sapiens) PubMed
1156.
Quiescent, therapy-resistant Sox2(+) cells propagate sonic hedgehog subgroup medulloblastoma by a mechanism that mirrors a neurogenic program. (Homo sapiens) PubMed
1157.
Consistent with a role of GLI in SOCS1 regulation, STAT1 phosphorylation is reduced in cells with active Hh/GLI signaling and IFN-small u, Cyrillic/STAT1 target gene activation is decreased (Homo sapiens) PubMed
1158.
Expression of Shh was correlated with the speed of gastric ulcer healing, promoting the regeneration of gastric mucosa (Homo sapiens) PubMed
1159.
this study identifies the myeloma autocrine Hh signaling pathway as a potential target for the treatment of MM. Targeting this pathway may improve the efficacy of chemotherapy in MM patients. (Homo sapiens) PubMed
1160.
Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. (Homo sapiens) PubMed
1161.
specific and potent kidney tubule-derived growth factor that promotes interstitial fibroblast proliferation and activation (Homo sapiens) PubMed
1162.
Shh signaling is activated in synovium of RA patients in vivo and in cultured FLS form RA patients in vitro, suggesting a role in the proliferation of FLS in RA. It may therefore be a novel therapeutic target in RA. (Homo sapiens) PubMed
1163.
The expression of Shh/Gli-1 was significantly associated with papillary thyroid carcinoma tumor size, clinical staging, and lymph node metastasis (Homo sapiens) PubMed
1164.
studies show that Shh, BMP2 and COL1 protein expression is decreased in trisomy 18 amniocytes compared to normal amniocytes. (Homo sapiens) PubMed
1165.
These data suggest that embelin can inhibit pancreatic cancer growth, angiogenesis and metastasis by suppressing Akt and Shh pathways, and can be developed for the treatment and/or prevention of pancreatic cancer. (Homo sapiens) PubMed
1166.
Data indicate a crucial role for the Sonic Hedgehog pathway in diosgenin-induced megakaryocytic differentiation in HEL erythroleukemia cells. (Homo sapiens) PubMed
1167.
Data indicate that tumor suppressor p53 can suppress canonical Hedgehog signaling via induction of patched domain containing 4 (PTCH53), a PTCH1 homolog. (Homo sapiens) PubMed
1168.
Data indicate that neutralizing hedgehog antibody MEDI-5304 represents a potent dual hedgehog inhibitor suitable for patients with tumors harboring elevated levels of sonic hedgehog (SHH) or indian hedgehog (IHH). (Homo sapiens) PubMed
1169.
Sonic hedgehog signaling in the lung. From development to disease. (Homo sapiens) PubMed
1170.
The negative regulation of glioma-associated oncogene 1 (Gli1), an important downstream effector of Hh, by the AMPK signal transduction pathway, is reported. (Homo sapiens) PubMed
1171.
High SHH expression is associated with cholangiocarcinoma. (Homo sapiens) PubMed
1172.
Findings support a paracrine mode of intratumoral Hedgehog signaling in malignant gliomas (Homo sapiens) PubMed
1173.
Hedgehog signaling components are markedly upregulated in medullary thyroid carcinoma. (Homo sapiens) PubMed
1174.
activation of SHH pathway, which is important in pituitary embryogenesis, appears to contribute to the pathogenesis of adamantinomatous craniopharyngiomas (Homo sapiens) PubMed
1175.
High Shh expression is associated with visceral pleural invasion and lymphatic thromboembolism in non-small-cell lung cancer. (Homo sapiens) PubMed
1176.
Here we report on five unrelated families with overlapping microduplications encompassing the Sonic hedgehog (SHH) limb enhancer ZPA regulatory sequence (ZRS) on chromosome 7q36 (Homo sapiens) PubMed
1177.
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog (Homo sapiens) PubMed
1178.
Shh protein expression is upregulated and is statistically correlated with age, tumor differentiation, depth of invasion, pathologic staging, and nodal metastasis in gastric cancer (Homo sapiens) PubMed
1179.
Expression of Shh, Gli-1, and MMP-9 was significantly upregulated in oral squamous cell carcinoma samples compared with non-cancerous tissue.Patients with low Shh, Gli-1, and MMP-9 expression survived longer than those with high expression. (Homo sapiens) PubMed
1180.
High SHH expression is associated with lymph node metastasis in non-small cell lung cancers. (Homo sapiens) PubMed
1181.
The expression of SHH in 50 human cholangiocellular carcinoma, cholangiocarcinoma cell line, and vivo growing tumors was measured by quantitative PCR (Homo sapiens) PubMed
1182.
Shh and EGFR signalling act additively to induce the ERK activation and the increases in cyclin D1 and Bcl2 thereby affecting proliferation and apoptosis in keratinocytes in vitro. (Homo sapiens) PubMed
1183.
demonstrated that downregulation of TRIM16 activated the sonic hedgehog pathway (Homo sapiens) PubMed
1184.
we demonstrate that components of Shh signaling, Patched and Gli3, are expressed in human platelets consistent with existence of functional Hedgehog signaling in these cells. (Homo sapiens) PubMed
1185.
Inhibition of Hedgehog signaling impedes cancer cell proliferation in part through induction of autophagy. (Homo sapiens) PubMed
1186.
SPOP plays critical roles in suppressing gastric tumorigenesis through inhibiting Hh/Gli2 signaling pathway. It may provide an alternative strategy for developing therapeutic agents of gastric cancer in future. (Homo sapiens) PubMed
1187.
It is involved in tumor initiation, cancer stem cell maintenance and angiogenesis. (Homo sapiens) PubMed
1188.
no relevant involvement of SHH in human fracture healing (Homo sapiens) PubMed
1189.
SHH signaling is differentially regulated in aneurysmal tissue and may play a causative role in the development of abdominal aortic aneurysms. (Homo sapiens) PubMed
1190.
SHH overexpression is associated with perineural invasion in pancreatic cancer. (Homo sapiens) PubMed
1191.
our findings reveal multiple and cooperative mechanisms of Shh upregulation in cancer cells (Homo sapiens) PubMed
1192.
Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling. (Homo sapiens) PubMed
1193.
from ESCs and induced pluripotent stem cells. SIGNIFICANCE STATEMENT: Our study presents a rapid and efficient protocol to generate human motoneurons from embryonic and induced pluripotent stem cells. (Homo sapiens) PubMed
1194.
A role of Shh in promoting glycolysis and proliferation of breast cancer cells via PFKFB3 phosphorylation (Homo sapiens) PubMed
1195.
Data indicate microRNA-9 (miR-9) as the target of patched protein 1 (PTCH1) in resistant glioblastoma multiforme (GBM) cells with concomitant activation of sonic hedgehog SHH signaling. (Homo sapiens) PubMed
1196.
SHH mutations or copy number variations are not a common cause of congenital hypopituitarism in patients without complex midline cerebral defects (Homo sapiens) PubMed
1197.
These findings revealed a novel role for Shh-Gli1 signals in epithelial-mesenchymal transition in ovarian cancer (Homo sapiens) PubMed
1198.
Aberrant activation of SHH-GLI signaling promotes upregulation of ABCG2 that plays key roles in the development of drug resistance. (Homo sapiens) PubMed
1199.
Demonstrated that sonic hedgehog is a PRL-regulated cytokine in breast cancer cells and part of the mechanism that induces osteoclast differentiation. (Homo sapiens) PubMed
1200.
Studied the proteome of human SHH-MB cancer stem-like cells before and after Retinoic Acid (RA)-induced differentiation. (Homo sapiens) PubMed
1201.
These results highlight the interaction between Wnt and SHH signaling pathways in dying tumor cells. (Homo sapiens) PubMed
1202.
our results demonstrated that upregulation of HIF-1alpha in NB promotes proliferation, migration and invasiveness via SHH signaling. (Homo sapiens) PubMed
1203.
The reemergence of SHH in epithelial cells could result in induction of myofibroblast differentiation in a Smo-dependent manner and subsequent Gli1 activation of the alpha-SMA promoter in pulmonary fibrosis. (Homo sapiens) PubMed
1204.
Shh and Gli1 are prognostic biomarkers for patients with resected PDAC. (Homo sapiens) PubMed
1205.
It is a regulator in tumorigenesis of hepatocellular carcinoma. (Homo sapiens) PubMed
1206.
Studies indicate that the hedgehog (Hh) signaling pathway has become one of the most studied potential therapeutic targets in hematological malignancies. (Homo sapiens) PubMed
1207.
Data suggest that nicotine increases the SHH-mediated malignant potential of pancreatic cancer stem cells and that GABA prevents these effects. (Homo sapiens) PubMed
1208.
Na,K-ATPase b1-subunit is a target of the Shh signaling pathway and loss of b1-subunit expression may contribute to tumor development and progression not only in carcinoma but also in medulloblastoma, a tumor of neuronal origin. (Homo sapiens) PubMed
1209.
Data indicate that resveratrol plus curcumin inhibits Hedgehog-Gli1 components in p21Waf1/Cip1 dependent manner. (Homo sapiens) PubMed
1210.
Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways. (Homo sapiens) PubMed
1211.
This article reviews the most relevant functions of Shh during cerebellar ontogenesis, underlying its role in physiological and pathological conditions. [review] (Homo sapiens) PubMed
1212.
Study shows that overexpression of SHH and Gli1 correlates with an increased risk along with a poor Myelodysplastic Syndrome prognosis. (Homo sapiens) PubMed
1213.
Here we show that MITF-A mRNA is predominantly expressed in all three human liver cancer cell lines examined. (Homo sapiens) PubMed
1214.
PDE4D interacts directly with Neuropilins, positive regulators of Hedgehog signal transduction pathway. (Homo sapiens) PubMed
1215.
High expression of Sonic Hedgehog Protein is associated with Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. (Homo sapiens) PubMed
1216.
Data suggest a role for hedgehog pathway (HhP) signaling in myeloid disease. (Homo sapiens) PubMed
1217.
appears to be responsive to the inhibition of GALNT1 and SHH signaling (Homo sapiens) PubMed
1218.
Data suggest that substrate specificity of hedgehog acyltransferase (HHAT) in palmitoylation reaction extends to oligopeptide fragments of Sonic hedgehog protein (SHH). (Homo sapiens) PubMed
1219.
Data indicate that regulation of sonic hedgehog (SHh)-GLI family zinc finger 1 (Gli1) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression. (Homo sapiens) PubMed
1220.
Increased SHH, PTCH, and GLI1 protein correlated positively with tumor grade, tumor depth and lymph node metastasis in Peutz-Jeghers syndrome. (Homo sapiens) PubMed
1221.
hyperactivity of Hh signaling resulted in EGFR-TKI resistance, by EMT introduction and ABCG2 upregulation, and blockade of Hh signaling synergistically increased sensitivity to EGFR-TKIs in primary and secondary resistant NSCLC cells (Homo sapiens) PubMed
1222.
Crocetinic acid inhibited the expression of both Shh and smoothened in pancreatic cancer stem cells, thereby inhibiting pancreatic tumorigenesis (Homo sapiens) PubMed
1223.
The sonic hedgehog protein, through its receptors, plays a role in embryo development, in idiopathic pulmonary fibrosis, and in small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma. Review. (Homo sapiens) PubMed
1224.
Results obtained from in vitro and in vivo studies demonstrate that Shh may function as an inducer of bladder cancer progression. Its expression correlates with advanced clinical stages and poor prognostic bladder cancer. (Homo sapiens) PubMed
1225.
The disruption of a novel limb cis-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis in a large French pedigree. (Homo sapiens) PubMed
1226.
during human brain development, Shh plays an important role in the specification of cortical progenitors (Homo sapiens) PubMed
1227.
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma (Homo sapiens) PubMed
1228.
The serum levels of IHH and SHH were significantly higher in autistic subjects than those of control subjects. The findings support a correlation between SHH, IHH and BDNF in autistic children, suggesting their pathological role in autism (Homo sapiens) PubMed
1229.
The roles of the SHH pathway in the context of limb development.[ review] (Homo sapiens) PubMed
1230.
Shh protein is upregulated in breast cancer. Expression of this protein was statistically correlated with age and malignant stage. (Homo sapiens) PubMed
1231.
Study demonstrated that SHH is overexpressed in gastric cancer and is associated with poor survival. (Homo sapiens) PubMed
1232.
sHH signaling pathway is involved in pancreatic cancer pain, and pancreatic stellate cells play an essential role in the process greatly by inducing Nerve Growth Factors. (Homo sapiens) PubMed
1233.
The recurring expression of NF-kB, SHH, K-RAS, and PTX3 in vimentin- and CD44-positive breast cancer cells allows to speculate that breast cells acquire the ability to express these molecules in concomitance to EMT phenomenon. (Homo sapiens) PubMed
1234.
This case, together with two others previously described, one presenting with esophageal atresia, the other with congenital esophageal stenosis, confirms the possible association between congenital esophageal malformations and 7q terminal deletion including SHH. (Homo sapiens) PubMed
1235.
Oleanolic acid markedly suppressed the activation of the STAT3 and SHH signaling pathways and inhibited the expression of the proangiogenic vascular endothelial growth factor A and basic fibroblast growth factor, two important target genes of the aforementioned signaling pathways. (Homo sapiens) PubMed
1236.
our data showed that paracrine Hh signaling mediated pro-angiogenic function of HSC and enhanced hepatoma growth. (Homo sapiens) PubMed
1237.
High SHH expression is associated with pancreatic cancer. (Homo sapiens) PubMed
1238.
High expression of SHH is associated with glioma chemoresistance. (Homo sapiens) PubMed
1239.
The results suggested that, when the rs61730970, rs200798148 and rs146535482 alleles of the Hedgehog gene lacked particular single nucleotide polymorphisms, the patients were associated with a greater risk of Hirschsprung's disease and/or anorectal malformations [HSCR: odds ratio (OR)=1.543, P=0.004; OR=1.494, P=0.007; rs146535482: OR=1.556, P=0.003, respectively. (Homo sapiens) PubMed
1240.
These findings suggest that the Hh signaling pathway in breast CSCs may contribute to the poor outcome of patients with breast cancer. (Homo sapiens) PubMed
1241.
SHH acted exclusively in a paracrine fashion on pancreatic stellate cells and influenced the growth of Pancreatic Cancer cells only indirectly, ADM could directly impact the growth of both Pancreatic Cancer cells and pancreatic stellate cells . (Homo sapiens) PubMed
1242.
data implicate perturbation of the Shh pathway in at least 37% of individuals with the hypothalamic hamartoma epilepsy syndrome, consistent with the concept of a developmental pathway brain disease (Homo sapiens) PubMed
1243.
These data reveal an interaction between the cytoplasmic domains of Ptch1 and that these domains modulate Ptch1 activity but are not essential for regulation of the Hh pathway. (Homo sapiens) PubMed
1244.
first report of the assessment of the frequency of GLI3/SHH/preZRS/ZRS in Chinese polydactyly patients to show any higher possibility of mutations or variants for the 4 genes or sequences in China (Homo sapiens) PubMed
1245.
these results reveal a novel role for E177-Zn(2+) in regulating SHH signaling that may involve critical, cilia basal-body localized changes in cross-linking and/or conformation. (Homo sapiens) PubMed
1246.
Studies indicate that sonic hedgehog protein (Shh) is upregulated specifically in renal tubular epithelium. (Homo sapiens) PubMed
1247.
importance of MAOA for initiating the pre-metastatic niche in stromal cells and promoting PCa metastasis to bone and visceral organs, mediated by activation of paracrine Shh-IL6-RANKL signaling underlying tumor-stromal interactions. (Homo sapiens) PubMed
1248.
findings suggest that Usp7 is important for MB cell proliferation and metastasis by activating Shh pathway, and is a putative therapeutic target for MBs (Homo sapiens) PubMed
1249.
Data indicate that agedunin induces its anti-metastatic effect through inhibition of sonic hedgehog protein [SHH] signaling. (Homo sapiens) PubMed
1250.
The study reveals several novel individual and repetitive mutations of SHH gene in Gallbladder Cancer and Cholelithiasis samples that may be used as diagnostic markers for gallbladder carcinogenesis. (Homo sapiens) PubMed
1251.
Data suggest that negative feedback mediated by GLI3 (GLI-Kruppel family member) acts to finely tune SHH (sonic hedgehog) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin which hyperactivates SHH signaling by abolishing negative feedback by GLI3. Restoration of intrinsic negative feedback by repressing nestin expression represents a promising approach to treat MB. [REVIEW] (Homo sapiens) PubMed
1252.
Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors. (Homo sapiens) PubMed
1253.
SHH siRNA synergistically enhanced cytotoxicity induced by itraconazole in MCF-7 cells. (Homo sapiens) PubMed
This suggests an important cross-talk between SHH and WIP1 pathways that accelerates tumorigenesis and supports WIP1 inhibition as a potential treatment strategy for MB. (Homo sapiens) PubMed
1256.
Study showed that SHH expression was significantly high among breast cancer patients with advanced tumor grade, stage, nodal involvement and metastasis and this expression strongly correlated with proliferation marker. (Homo sapiens) PubMed
1257.
We found a novel 7q36.3 duplication involving 2 genes (SHH and RBM33) in a patient with complete corpus callosum agenesis (Figure), moderate learning difficulties, and macrocephaly (Homo sapiens) PubMed
1258.
CHSY1 overexpression in HCC contributes to the malignant behavior of hepatocellular carcinoma cells via activation of the hedgehog signaling pathway. (Homo sapiens) PubMed
1259.
Accumulating evidence suggest that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two neoplastic molecular programs: the retinoid metabolism and Hedgehog pathways. (Review) (Homo sapiens) PubMed
1260.
Altogether, these data suggested that curcumin inhibited the activities of BCSCs through suppressing Shh pathway, which might be an effective chemopreventive agent for bladder cancer intervention. (Homo sapiens) PubMed
1261.
High SHH expression is associated with Small Cell Lung Cancer. (Homo sapiens) PubMed
1262.
Methylation at K436 and K595 respectively by Set7 increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh signaling activation. (Homo sapiens) PubMed
1263.
Studies suggest that embryonic signaling pathways, the likes of Notch, Wnt, and Hedgehog and tumor marker Oct-4 offer targets for cascade-specific molecular inhibition as they are fundamental to (cancer and normal) stem cell maintenance and growth. (Homo sapiens) PubMed
1264.
SHH activation is associated with Rhabdomyosarcoma. (Homo sapiens) PubMed
1265.
Gorlin syndrome-derived induced pluripotent stem cells (iPSCs) expressed lower basal levels than control iPSCs of the genes encoding the Hh ligands Indian Hedgehog (IHH) and Sonic Hedgehog (SHH). (Homo sapiens) PubMed
1266.
Studies suggest significance of other signaling aside from hedgehog in the pathogenesis of basal cell carcinoma (BCC) of the skin. (Homo sapiens) PubMed
1267.
High SHH expression is associated with esophageal squamous cell carcinoma. (Homo sapiens) PubMed
1268.
Expression of SHH and GLI1 may be useful prognostic markers of Merkel cell carcinoma because increased expression was associated with better prognosis. (Homo sapiens) PubMed
1269.
Findings suggest that oral squamous cell carcinoma (OSCC)derived sonic hedgehog protein (SHH) stimulates angiogenesis at the tumor invasive front. (Homo sapiens) PubMed
1270.
SHH can promote cell growth and cell osteoblastic/cementoblastic differentiation via BMP pathway (Homo sapiens) PubMed
1271.
the effect gene of the Shh pathway, gli1, was found to have a reduced level of expression along with a decreased expression of gli2. (Homo sapiens) PubMed
1272.
In an in vitro model of LPS inflammation of the blood-brain barrier, sonic hedgehog signaling was activated by Wip1 overexpression and inhibited by silencing. Wip1 may protect the BBB against LPS damage via SHH signaling. (Homo sapiens) PubMed
1273.
during Hedgehog signaling, ligand binding inhibits Patched by trapping it in an inactive conformation, a mechanism that explains the dramatically reduced activity of oncogenic Patched1 mutants. (Homo sapiens) PubMed
1274.
influences sweat gland differentiation of stem cells (Homo sapiens) PubMed
1275.
Results show SHH proteolysis is under the mechanism of Scube2 which is enriched at the surface of Shh-producing cells by heparan sulfate proteoglycans. (Homo sapiens) PubMed
1276.
GPT2 reduced alpha-ketoglutarate level in cells leading to the inhibition of proline hydroxylase 2 (PHD2) activity involved in the regulation of HIF1alpha stability. Accumulation of HIF1alpha, resulting from GPT2-alpha-ketoglutarate-PHD2 axis, constitutively activates sonic hedgehog (Shh) signaling pathway. (Homo sapiens) PubMed
1277.
Hh signaling activation might reflect aggressive tumoral behavior, since high epithelial GLI2 expression positively correlates with a higher pathological Gleason score. Moreover, higher epithelial GLI3 expression is an independent marker of a more favorable prognosis. (Homo sapiens) PubMed
1278.
The results showed that Shh and Gli1 were upregulated in prostate cancer tissues and were targeted by a phytogenic neoplastic compound carnosol. (Homo sapiens) PubMed
1279.
Oncogenic activation of SHH is associated with Rubinstein-Taybi Syndrome and Medulloblastoma. (Homo sapiens) PubMed
1280.
Gpr161 is a critical factor in the basal suppression machinery of Shh signaling, neural tube morphogenesis and closure. (Review) (Homo sapiens) PubMed
1281.
NAFLD progression is usually accompanied by activation of the Sonic hedgehog (SHH) pathway leading to fibrous buildup (scar tissue) and inflammation of the liver tissue. For the first time patients with holoprosencephaly, a disease caused by SHH signaling mutations, are shown to have increased liver steatosis independent of obesity. (Homo sapiens) PubMed
1282.
Case Report: medullablastoma with activated SHH expression. (Homo sapiens) PubMed
1283.
Epithelial-mesenchymal transition programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. (Homo sapiens) PubMed
1284.
Shh and Gli1 expression were associated with lymph node metastasis, TNM stage and tumor recurrence, suggesting Shh and Gli1 protein could become the valuable biomarker in evaluating the lymph node metastasis in oral squamous cell carcinoma. (Homo sapiens) PubMed
1285.
These findings showed the upexpression of sonic hedgehog and vascular endothelial growth factor with co-localization in varicocele veins which imply that the reducing hypoxia or using sonic hedgehog antagonists may be helpful for this vascular disease. (Homo sapiens) PubMed
1286.
In conclusion, our data suggest that overexpression of the Hedgehog components SHH, GLI2 and FOXA2 might be used as markers of an aggressive hemangioma. (Homo sapiens) PubMed
1287.
Identify SMO-dependent Shh signalling as a specific process for the activation of adventitial fibroblasts and the subsequent proliferation of smooth muscle cells and neointima formation. (Homo sapiens) PubMed
1288.
High SHH expression is associated with radioresistance in esophageal adenocarcinoma. (Homo sapiens) PubMed
1289.
SHH is expressed in cilia in the airway epithelial cells.SHH may mediate noncanonical hedgehog signaling through motile cilia to dampen respiratory defenses. (Homo sapiens) PubMed
1290.
SHH-related signaling pathway affects antineoplastic drug resistance in cultured glioma cells. (Homo sapiens) PubMed
1291.
Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling. (Homo sapiens) PubMed
1292.
Structure-guided mutational analysis shows that interaction between ShhN and Ptch1 is steroid-dependent. (Homo sapiens) PubMed
1293.
Blockade of the Shh signaling pathway could reduce cell proliferation and migration only in MDA-MB-231 cells. Hh pathway inhibitor-1 (HPI-1) increased the percentages of late apoptotic cells in MDA-MB-231 cells and early apoptotic cells in T2 cells (Homo sapiens) PubMed
1294.
Histone deacetylase 6 (HDAC6) inhibition enhanced glioma stem cells (GSCs) radiosensitivity via inactivating sonic hedgehog protein (SHH)/glioma-associated oncogene homolog 1 (Gli1) pathway. (Homo sapiens) PubMed
1295.
Disturbed SHH link between KIF7 and C5orf42 contributes to neurodevelopmental features characteristic of C5orf42-related ciliopathies. (Homo sapiens) PubMed
1296.
The elevated levels of both serum Shh and IL-6 were mainly observed in BC patients who had a significantly higher risk of early recurrence and bone metastasis, and associated with a worse survival for patients with progressive metastatic BC. (Homo sapiens) PubMed
1297.
We did not detect any mutations in GLI3, SHH, or SHH ZRS in the 77 nonsyndromic polydactyly patients. (Homo sapiens) PubMed
1298.
3.5-angstrom resolution cryo-electron microscopy structure of native Sonic Hedgehog (SHH-N) in complex with PTCH1 at a physiological calcium concentration reconciles previous disparate findings and demonstrates that one SHH-N molecule engages both epitopes to bind two PTCH1 receptors in an asymmetric manner. (Homo sapiens) PubMed
1299.
atomic insights into the recognition of the N-terminal domain of Sonic Hedgehog (HH-N) by PTCH1, offers a structural basis for cooperative binding of HH-N to various receptors and serves as a molecular framework for HH signalling and its malfunction in disease (Homo sapiens) PubMed
1300.
The study suggested that Hh/Gli1 cascade (canonical pathway) as well as Gsk3beta-Gli1 crosstalk (non-canonical pathway) play crucial role in estrogen-dependent cell proliferation in endometrial hyperplasia. (Homo sapiens) PubMed
1301.
The SHH expression increased during development, shifting from progenitor cells in the proliferative zones to neurons, both glutamatergic and GABAergic, and astrocytes in upper cortical compartments. (Homo sapiens) PubMed
1302.
ASS1 is associated with sonic hedgehog activation as part of a periportal program expressed in hepatocellular adenomas. (Homo sapiens) PubMed
1303.
Combined use of SHH and HDAC inhibitors resulted in significantly greater downregulation of SHH and PI3K/mTOR signaling. (Homo sapiens) PubMed
1304.
Inversin required for ciliary translocation of Smo and activation of the Shh pathway; Shh signaling promotes inversin phosphorylation by PKA and inversin-Smo interaction (Homo sapiens) PubMed
1305.
These findings provide novel information on Shh signaling during ischemia in humans, with potentially important biological and clinical implications. (Homo sapiens) PubMed
1306.
Of note, the enforced expression of MEKK1 or the exposure of medulloblastoma cells to the MEKK1 activator, Nocodazole, resulted in a marked inhibitory effect on GLI1 activity and tumor cell proliferation and viability. Taken together, the results of this study shed light on a novel regulatory mechanism of HH signaling, with potentially relevant implications in cancer therapy. (Homo sapiens) PubMed
1307.
Overexpression of the Hedgehog signaling components SHH and GLI2 and its target gene FOXA2 in HH were similar to those found in aggressive skin hemangioma and KHE, their expression being significantly higher than in mild skin hemangioma. (Homo sapiens) PubMed
1308.
Study reports the cryo-electron microscopy structure of tetrameric PTCH1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog at a 4:2 stoichiometric ratio. The structure shows that four PTCH1 protomers are organized as a loose dimer of dimers. (Homo sapiens) PubMed
1309.
results showed that the microtextured/nanotextured topographies induced significantly high expression of Sonic Hedgehog (SHH), Smoothened (SMO) and GLI1 in the HUVECs as well as high activation of Hedgehog-Gli1 signaling, compared to the smooth surface. (Homo sapiens) PubMed
1310.
The upregulation of SHH expression in allergic bronchial epithelia contributes to goblet cell metaplasia. (Homo sapiens) PubMed
1311.
These findings reveal a molecular basis of TSPAN8-enhanced Sonic Hedgehog signaling and highlight a role for TSPAN8 in promoting cancer stemness. (Homo sapiens) PubMed
1312.
SHH-Patched signal transduction is instrumental for development in Drosophila and for tumor cells communication in humans. (Homo sapiens) PubMed
1313.
Our results manifested that genes involved in SHH signaling pathway showed identical expression patterns, while genes involved in BMP as well as FGF pathway exhibited similar but distinct expression patterns in humans to those in the mouse. (Homo sapiens) PubMed
1314.
The results indicate that Shh signaling modulates antioxidant defense system and stabilizes mitochondrial dynamics by suppressing Drp1 protein which maintains survival of endometrial hyperplasial cells against oxidative stress. (Homo sapiens) PubMed
1315.
The findings suggest that SHH signaling pathway mediates proliferation and migration of RA-FLSs via MAPK/ERK pathway and may contribute to progression of rheumatoid arthritis (RA). (Homo sapiens) PubMed
1316.
Differential expression of sonic hedgehog in lung adenocarcinoma and lung squamous cell carcinoma (Homo sapiens) PubMed
1317.
this report present an incomplete phenotype linked to the SHH gene with familial coloboma and microcephaly. It also confirms that WES remains an efficient tool to identify causal genes in atypical phenotypes of well-known genes. (Homo sapiens) PubMed
1318.
The SHH pathway was identified in human Rhabdosphincter.Rhabdosphincter growth increased with SHH treatment, indicating intervention may be possible to enhance Rhabdosphincter regeneration (Homo sapiens) PubMed
1319.
Rictor/mTORC2 has opposing functions in neural stem cells and granule cell precursors in the adult and the developing brain, promoting malignant gliomas and suppressing SHH-medulloblastoma formation, respectively. (Homo sapiens) PubMed
1320.
on a molecular level the human and mouse HH-dependent MB are quite distinct, with human, but not mouse, tumors characterized by the presence of markers of increased oxidative phosphorylation and mitochondrial biogenesis. (Homo sapiens) PubMed
1321.
Shh expression was significantly upregulated in the stromal and epithelial compartments of poorly-differentiated Pancreatic ductal adenocarcinoma samples, with a strong correlation with the amount of stroma present. (Homo sapiens) PubMed
1322.
High Shh expression is correlated with increased lymph node metastasis in Urothelial Bladder Cancer. (Homo sapiens) PubMed
1323.
To determine if there is a correlation between preaxial polydactyly and radial aplasia, we induced ectopic Sonic hedgehog signalling during chicken limb development with application of a smoothened-agonist (SAG) or retinoic acid. We demonstrate that ectopic Sonic hedgehog signalling may cause both preaxial polydactyly and predictable forearm anomalies. (Homo sapiens) PubMed
1324.
Here, the crystal structure of human Shh-N is presented at 1.43 A degrees resolution, representing a landmark in the characterization of this protein. (Homo sapiens) PubMed
1325.
SHH activity clearly declines with aging and subsequently attenuates endometrial stem cell loss and dysfunction in the aging process by suppressing the expression of SERPINB2. (Homo sapiens) PubMed
1326.
Microparticles carrying Sonic hedgehog (Shh) morphogen increase both the vasculogenesis of endothelial progenitor cells and their capacity to produce NO, including EPC from patients who have recently suffered an acute myocardial infarction. (Homo sapiens) PubMed
1327.
In medulloblastomas (MBs), the expression and activity of RE1-silencing transcription factor (REST) is increased in tumors driven by the sonic hedgehog (SHH) pathway. (Homo sapiens) PubMed
1328.
these findings suggest that HDM/TGFbeta1 may induce EMT in HBECs via an SHH signaling mechanism. Inhibition of SHH signaling may be a novel therapeutic method for preventing airway remodeling in asthma. (Homo sapiens) PubMed
1329.
This study identifies Shh as a novel mitogen that selectively promotes lymphatic, but not vascular, endothelial cell proliferation (Homo sapiens) PubMed
1330.
results indicate that the preformed chromatin structure of the Shh locus is sustained by multiple components and acts to reinforce enhancer-promoter communication for robust transcription (Homo sapiens) PubMed
1331.
GATA-6 inhibited the proliferation and migration of LSCC cells by transcriptionally inhibiting the expression of Shh (Homo sapiens) PubMed
1332.
These results suggest that autocrine effects of SHH induce cancer invasion, and paracrine effects of SHH govern parenchyma-stromal interactions of oral squamous cell carcinoma (OSCC). The role of the SHH pathway is to promote growth and invasion. (Homo sapiens) PubMed
1333.
Increased SHH expression is associated with neuroblastoma. (Homo sapiens) PubMed
1334.
the levels of SHH and IHH proteins were significantly correlated with the expression of proteins involved in the TGF-b1 pathway. Moreover, the expression of the HH pathway ligands was positively associated with the expression of TAZ, supporting the notion that TAZ may play a role in the activation of the HH pathway thereby regulating the expression of its ligands (Homo sapiens) PubMed
1335.
HHIPL1 cellular localization, interaction with sonic hedgehog (SHH), and influence on hedgehog signaling were tested. Human aortic smooth muscle cell phenotypes and hedgehog signaling were investigated after gene knockdown. Immunoprecipitation shows that recombinant HHIPL1 and SHH proteins interact. (Homo sapiens) PubMed
1336.
Results find the LMBR1 protein harboring point mutation in the ZRS regulatory sequence enhanced the binding affinity for HnRNPK and upregulated SHH expression. (Homo sapiens) PubMed
1337.
N-terminal fragment of recombinant Shh significantly decreased K(+)-dependent ATP-hydrolyzing activity, which is sensitive to an inhibitor of H(+),K(+)-ATPase (SCH28080), in hog gastric tubulovesicles and membrane fractions of the H(+),K(+)-ATPase-expressing cells. (Homo sapiens) PubMed
1338.
gigaxonin as a key E3 ligase that positively controls the initiation of Shh transduction, and reveal the causal role of Shh dysfunction in motor deficits, thus highlighting the developmental origin of giant axonal neuropathy. (Homo sapiens) PubMed
1339.
Hypoxia upregulates SHh expression and activates SHH signaling pathway in cholangiocarcinoma cells. (Homo sapiens) PubMed
1340.
tumor-derived SHH has a role in promoting tumor-associated macrophage M2 polarization, and in a mechanism for tumor-associated macrophage-mediated immunosuppression (Homo sapiens) PubMed
1341.
SOX2-induced upregulation of lncRNA LINC01510 promotes papillary thyroid carcinoma progression by modulating miR-335/SHH and activating Hedgehog pathway (Homo sapiens) PubMed
1342.
RAB family small GTP binding protein RAB 23 (Rab23) and ADP-ribosylation factor-like 13B (Arl13b) have been implicated in ciliopathy-associated human diseases and could regulate hedgehog proteins (Hh) signalling cascade in multifaceted manners [Review]. (Homo sapiens) PubMed
1343.
The results revealed that EIF5A regulated the proliferation of pancreatic cancer through the SHH signaling pathway while decreasing the gemcitabine sensitivity. (Homo sapiens) PubMed
High SHH expression is associated with Myelodysplastic Syndrome. (Homo sapiens) PubMed
1346.
Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma. (Homo sapiens) PubMed
1347.
SHH expression in placental tissues and trophoblast cell oxidative stress injury during preeclampsia. (Homo sapiens) PubMed
1348.
Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis. (Homo sapiens) PubMed
1349.
[Exploring parent-of-origin effects for non-syndromic cleft lip with or without cleft palate on PTCH1, PTCH2, SHH, SMO genes in Chinese case-parent trios]. (Homo sapiens) PubMed
1350.
Genetic landscape and ligand-dependent activation of sonic hedgehog-Gli1 signaling in chordomas: a novel therapeutic target. (Homo sapiens) PubMed
1351.
Novel Interplay Between Sonic Hedgehog and Transforming Growth Factor-beta1 in Human Nonalcoholic Steatohepatitis. (Homo sapiens) PubMed
1352.
NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma. (Homo sapiens) PubMed
1353.
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells. (Homo sapiens) PubMed
1354.
Synonymous variants in holoprosencephaly alter codon usage and impact the Sonic Hedgehog protein. (Homo sapiens) PubMed
Web services initiated January, 1994 as Portable Dictionary of the Mouse Genome; June 15, 2001 as WebQTL; and Jan 5, 2005 as GeneNetwork.
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